Ankrd6 is a mammalian functional homolog of Drosophila planar cell polarity gene diego and regulates coordinated cellular orientation in the mouse inner ear

The coordinated polarization of neighboring cells within the plane of the tissue, known as planar cell polarity (PCP), is a recurring theme in biology. It is required for numerous developmental processes for the form and function of many tissues and organs across species. The genetic pathway regulat...

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Veröffentlicht in:	Developmental biology 2014-11, Vol.395 (1), p.62-72
Hauptverfasser:	Jones, Chonnettia, Qian, Dong, Kim, Sun Myoung, Li, Shuangding, Ren, Dongdong, Knapp, Lindsey, Sprinzak, David, Avraham, Karen B, Matsuzaki, Fumio, Chi, Fanglu, Chen, Ping
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Genetically Modified Blotting, Western Body Patterning - genetics Body Patterning - physiology Carrier Proteins - genetics Carrier Proteins - metabolism cell polarity Cell Polarity - genetics Cell Polarity - physiology Cells, Cultured Cytoskeletal Proteins - genetics Cytoskeletal Proteins - metabolism Drosophila Drosophila Proteins - genetics Drosophila Proteins - metabolism Ear, Inner - cytology Ear, Inner - metabolism ears Embryo, Mammalian - cytology Embryo, Mammalian - metabolism Eye - cytology Eye - metabolism fibroblasts Fibroblasts - cytology Fibroblasts - metabolism gene overexpression genes Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Hair Cells, Auditory - cytology Hair Cells, Auditory - metabolism Immunohistochemistry Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism knockout mutants membrane proteins mice Mice, Knockout Microscopy, Confocal Mutation Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism phenotype Wings, Animal - cytology Wings, Animal - metabolism Wnt Signaling Pathway - genetics Wnt Signaling Pathway - physiology
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