Complement Factor 3 Could Be an Independent Risk Factor for Mortality in Patients with HBV Related Acute-on-Chronic Liver Failure
The complement is thought to be involved in the pathogenesis of multiple liver disorders. However, its role in patients with HBV related acute-on-chronic liver failure (HBV-ACLF) remains unclear. Serum levels of the third and fourth complement components (C3, C4) and complement function (CH50) were...
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| description | The complement is thought to be involved in the pathogenesis of multiple liver disorders. However, its role in patients with HBV related acute-on-chronic liver failure (HBV-ACLF) remains unclear. Serum levels of the third and fourth complement components (C3, C4) and complement function (CH50) were examined in this prospective, observational study. Associations between their expression and disease activity were analyzed. Survival was analyzed by Kaplan-Meier curves. Predictors of clinical outcome were determined by Cox regression analysis. C3, C4, and CH50 levels were significantly lower in HBV-ACLF patients compared to controls. C3, C4, and CH50 levels were negatively correlated with Tbil levels but positively associated with PTA levels. C3 levels were negatively associated with MELD-Na. C3 levels were significantly lower in HBV-ACLF patients who died compared to patients who survived. In a median hospital stay of 39 days, mortality occurred in 41 patients with a progressive increase based on C3 grade (P=0.008). The actuarial probability of developing mortality was significantly higher in patients with low C3 grade compared to those with high C3 grade (P |
| doi_str_mv | 10.1155/2016/3524842 |
| format | Article |
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However, its role in patients with HBV related acute-on-chronic liver failure (HBV-ACLF) remains unclear. Serum levels of the third and fourth complement components (C3, C4) and complement function (CH50) were examined in this prospective, observational study. Associations between their expression and disease activity were analyzed. Survival was analyzed by Kaplan-Meier curves. Predictors of clinical outcome were determined by Cox regression analysis. C3, C4, and CH50 levels were significantly lower in HBV-ACLF patients compared to controls. C3, C4, and CH50 levels were negatively correlated with Tbil levels but positively associated with PTA levels. C3 levels were negatively associated with MELD-Na. C3 levels were significantly lower in HBV-ACLF patients who died compared to patients who survived. In a median hospital stay of 39 days, mortality occurred in 41 patients with a progressive increase based on C3 grade (P=0.008). The actuarial probability of developing mortality was significantly higher in patients with low C3 grade compared to those with high C3 grade (P<0.001). Multivariate Cox regression analysis showed that C3 levels were an independent predictor of mortality. Complement played a pathogenic role in HBV-ACLF patients and C3 was an independent predictor of mortality.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2016/3524842</identifier><identifier>PMID: 27144164</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Adult ; Comparative analysis ; Complement C3 - metabolism ; Complement C4 - metabolism ; Complement Hemolytic Activity Assay - methods ; End Stage Liver Disease - blood ; End Stage Liver Disease - etiology ; End Stage Liver Disease - mortality ; Female ; Hepatitis B ; Hepatitis B - blood ; Hepatitis B - complications ; Hepatitis B - mortality ; Hepatitis B virus ; Humans ; Liver cirrhosis ; Liver failure ; Liver Failure, Acute - blood ; Liver Failure, Acute - etiology ; Liver Failure, Acute - mortality ; Male ; Mortality ; Patient outcomes ; Prospective Studies ; Risk Factors ; Rodents ; Studies</subject><ispartof>BioMed research international, 2016-01, Vol.2016 (2016), p.1-10</ispartof><rights>Copyright © 2016 Geng-lin Zhang et al.</rights><rights>COPYRIGHT 2016 John Wiley & Sons, Inc.</rights><rights>Copyright © 2016 Geng-lin Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2016 Geng-lin Zhang et al. 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c532t-2970490d8913cd1212164fb7c0dd67d5acbd856a663e554752acb46c59412c3</citedby><cites>FETCH-LOGICAL-c532t-2970490d8913cd1212164fb7c0dd67d5acbd856a663e554752acb46c59412c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837248/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837248/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27144164$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Tulkens, Paul M.</contributor><creatorcontrib>Gao, Zhiliang</creatorcontrib><creatorcontrib>Xie, Chan</creatorcontrib><creatorcontrib>Zhang, Xiao-hong</creatorcontrib><creatorcontrib>Liu, Jing</creatorcontrib><creatorcontrib>Ye, Yi-nong</creatorcontrib><creatorcontrib>Zhang, Ting</creatorcontrib><creatorcontrib>Zhang, Geng-lin</creatorcontrib><creatorcontrib>Peng, Liang</creatorcontrib><title>Complement Factor 3 Could Be an Independent Risk Factor for Mortality in Patients with HBV Related Acute-on-Chronic Liver Failure</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>The complement is thought to be involved in the pathogenesis of multiple liver disorders. However, its role in patients with HBV related acute-on-chronic liver failure (HBV-ACLF) remains unclear. Serum levels of the third and fourth complement components (C3, C4) and complement function (CH50) were examined in this prospective, observational study. Associations between their expression and disease activity were analyzed. Survival was analyzed by Kaplan-Meier curves. Predictors of clinical outcome were determined by Cox regression analysis. C3, C4, and CH50 levels were significantly lower in HBV-ACLF patients compared to controls. C3, C4, and CH50 levels were negatively correlated with Tbil levels but positively associated with PTA levels. C3 levels were negatively associated with MELD-Na. C3 levels were significantly lower in HBV-ACLF patients who died compared to patients who survived. In a median hospital stay of 39 days, mortality occurred in 41 patients with a progressive increase based on C3 grade (P=0.008). The actuarial probability of developing mortality was significantly higher in patients with low C3 grade compared to those with high C3 grade (P<0.001). Multivariate Cox regression analysis showed that C3 levels were an independent predictor of mortality. Complement played a pathogenic role in HBV-ACLF patients and C3 was an independent predictor of mortality.</description><subject>Adult</subject><subject>Comparative analysis</subject><subject>Complement C3 - metabolism</subject><subject>Complement C4 - metabolism</subject><subject>Complement Hemolytic Activity Assay - methods</subject><subject>End Stage Liver Disease - blood</subject><subject>End Stage Liver Disease - etiology</subject><subject>End Stage Liver Disease - mortality</subject><subject>Female</subject><subject>Hepatitis B</subject><subject>Hepatitis B - blood</subject><subject>Hepatitis B - complications</subject><subject>Hepatitis B - mortality</subject><subject>Hepatitis B virus</subject><subject>Humans</subject><subject>Liver cirrhosis</subject><subject>Liver failure</subject><subject>Liver Failure, Acute - blood</subject><subject>Liver Failure, Acute - etiology</subject><subject>Liver Failure, Acute - mortality</subject><subject>Male</subject><subject>Mortality</subject><subject>Patient outcomes</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><subject>Rodents</subject><subject>Studies</subject><issn>2314-6133</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqN0u9r1DAYB_Aiihtz73wtAd8IWpffad8It-Lc4ESZ4tuQS9JdZpucSbqxl_7nptztnL5aStqQfvg2fXiq6iWC7xFi7ARDxE8Iw7Sh-El1iAmiNUcUPd2vCTmojlO6hmU0iMOWP68OsECUIk4Pq99dGDeDHa3P4EzpHCIgoAvTYMCpBcqDC2_sxpZbAZcu_bxXfZmfQ8xqcPkOOA--quwKSuDW5TU4P_0BLu2gsjVgoads6-Drbh2Ddxos3Y2NJcgNU7Qvqme9GpI93j2Pqm9nH7935_Xyy6eLbrGsNSM417gVkLbQNC0i2iBcLk77ldDQGC4MU3plGsYV58QyRgXDZYdyzVqKsCZH1Ydt6mZajdboctKoBrmJblTxTgbl5L9vvFvLq3AjaUNEKW8JeLMLiOHXZFOWo0vaDoPyNkxJItGItilFJ4-isCUU4kJf_0evwxR9qcOsUPkuEe1fdaUGK53vQzminkPlgmEoZkeLerdVOoaUou33f4egnLtFzt0id91S-KuHFdnj-94o4O0WrJ036tY9Ms4WY3v1QLeCsIb8Afnyzjo</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>Gao, Zhiliang</creator><creator>Xie, Chan</creator><creator>Zhang, Xiao-hong</creator><creator>Liu, Jing</creator><creator>Ye, Yi-nong</creator><creator>Zhang, Ting</creator><creator>Zhang, Geng-lin</creator><creator>Peng, Liang</creator><general>Hindawi Publishing Corporation</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160101</creationdate><title>Complement Factor 3 Could Be an Independent Risk Factor for Mortality in Patients with HBV Related Acute-on-Chronic Liver Failure</title><author>Gao, Zhiliang ; Xie, Chan ; Zhang, Xiao-hong ; Liu, Jing ; Ye, Yi-nong ; Zhang, Ting ; Zhang, Geng-lin ; Peng, Liang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c532t-2970490d8913cd1212164fb7c0dd67d5acbd856a663e554752acb46c59412c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Comparative analysis</topic><topic>Complement C3 - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BioMed research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gao, Zhiliang</au><au>Xie, Chan</au><au>Zhang, Xiao-hong</au><au>Liu, Jing</au><au>Ye, Yi-nong</au><au>Zhang, Ting</au><au>Zhang, Geng-lin</au><au>Peng, Liang</au><au>Tulkens, Paul M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Complement Factor 3 Could Be an Independent Risk Factor for Mortality in Patients with HBV Related Acute-on-Chronic Liver Failure</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2016-01-01</date><risdate>2016</risdate><volume>2016</volume><issue>2016</issue><spage>1</spage><epage>10</epage><pages>1-10</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>The complement is thought to be involved in the pathogenesis of multiple liver disorders. However, its role in patients with HBV related acute-on-chronic liver failure (HBV-ACLF) remains unclear. Serum levels of the third and fourth complement components (C3, C4) and complement function (CH50) were examined in this prospective, observational study. Associations between their expression and disease activity were analyzed. Survival was analyzed by Kaplan-Meier curves. Predictors of clinical outcome were determined by Cox regression analysis. C3, C4, and CH50 levels were significantly lower in HBV-ACLF patients compared to controls. C3, C4, and CH50 levels were negatively correlated with Tbil levels but positively associated with PTA levels. C3 levels were negatively associated with MELD-Na. C3 levels were significantly lower in HBV-ACLF patients who died compared to patients who survived. In a median hospital stay of 39 days, mortality occurred in 41 patients with a progressive increase based on C3 grade (P=0.008). The actuarial probability of developing mortality was significantly higher in patients with low C3 grade compared to those with high C3 grade (P<0.001). Multivariate Cox regression analysis showed that C3 levels were an independent predictor of mortality. Complement played a pathogenic role in HBV-ACLF patients and C3 was an independent predictor of mortality.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>27144164</pmid><doi>10.1155/2016/3524842</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Comparative analysis Complement C3 - metabolism Complement C4 - metabolism Complement Hemolytic Activity Assay - methods End Stage Liver Disease - blood End Stage Liver Disease - etiology End Stage Liver Disease - mortality Female Hepatitis B Hepatitis B - blood Hepatitis B - complications Hepatitis B - mortality Hepatitis B virus Humans Liver cirrhosis Liver failure Liver Failure, Acute - blood Liver Failure, Acute - etiology Liver Failure, Acute - mortality Male Mortality Patient outcomes Prospective Studies Risk Factors Rodents Studies |
| title | Complement Factor 3 Could Be an Independent Risk Factor for Mortality in Patients with HBV Related Acute-on-Chronic Liver Failure |
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