Gut microbiome–derived metabolites modulate intestinal epithelial cell damage and mitigate graft-versus-host disease

Irradiation to condition hosts for bone marrow transplantation leads to alterations in intestinal microbiota. Reddy and colleagues demonstrate that these changes result in reduced butyrate production and breakdown of intestinal barrier function. The effect of alterations in intestinal microbiota on...

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Veröffentlicht in:	Nature immunology 2016-05, Vol.17 (5), p.505-513
Hauptverfasser:	Mathewson, Nathan D, Jenq, Robert, Mathew, Anna V, Koenigsknecht, Mark, Hanash, Alan, Toubai, Tomomi, Oravecz-Wilson, Katherine, Wu, Shin-Rong, Sun, Yaping, Rossi, Corinne, Fujiwara, Hideaki, Byun, Jaeman, Shono, Yusuke, Lindemans, Caroline, Calafiore, Marco, Schmidt, Thomas M, Honda, Kenya, Young, Vincent B, Pennathur, Subramaniam, van den Brink, Marcel, Reddy, Pavan
Format:	Artikel
Sprache:	eng
Schlagworte:	14 14/28 631/250 631/250/1904 631/326/41 631/80/458/1275 692/699/249/1529 82 82/58 Acetylation - drug effects Animals Biomedicine Bone marrow Bone Marrow Transplantation - adverse effects Bone Marrow Transplantation - methods Butyrates - immunology Butyrates - metabolism Butyrates - pharmacology Cells, Cultured Development and progression Epithelial Cells - immunology Epithelial Cells - metabolism Epithelial Cells - microbiology Fatty acids Fatty Acids, Volatile - immunology Fatty Acids, Volatile - metabolism Female Gas Chromatography-Mass Spectrometry Gastrointestinal Microbiome - immunology Gastrointestinal Microbiome - physiology Gene Expression - immunology Genetic aspects Graft versus host reaction Graft vs Host Disease - etiology Graft vs Host Disease - immunology Graft vs Host Disease - microbiology Health aspects Histone Acetyltransferases - genetics Histone Acetyltransferases - immunology Histone Acetyltransferases - metabolism Histone Deacetylases - genetics Histone Deacetylases - immunology Histone Deacetylases - metabolism Histones - immunology Histones - metabolism Immunoblotting Immunology Infectious Diseases Intestines - cytology Intestines - immunology Intestines - microbiology Metabolites Metabolome - immunology Mice, Inbred BALB C Mice, Inbred C57BL Microbiota (Symbiotic organisms) Properties Reverse Transcriptase Polymerase Chain Reaction T-Lymphocytes - immunology T-Lymphocytes - metabolism Transplantation, Homologous
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