Increased yield of actionable mutations using multi-gene panels to assess hereditary cancer susceptibility in an ethnically diverse clinical cohort

This study aims to assess multi-gene panel testing in an ethnically diverse clinical cancer genetics practice. We conducted a retrospective study of individuals with a personal or family history of cancer undergoing clinically indicated multi-gene panel tests of 6–110 genes, from six commercial labo...

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Veröffentlicht in:	Cancer genetics 2016-04, Vol.209 (4), p.130-137
Hauptverfasser:	Ricker, Charité, Culver, Julie O, Lowstuter, Katrina, Sturgeon, Duveen, Sturgeon, Julia D, Chanock, Christopher R, Gauderman, William J, McDonnell, Kevin J, Idos, Gregory E, Gruber, Stephen B
Format:	Artikel
Sprache:	eng
Schlagworte:	cancer risk assessment Cohort Studies ethnic minorities Female Genetic Predisposition to Disease - ethnology Genetic Predisposition to Disease - genetics Hematology, Oncology and Palliative Medicine Hereditary cancer Humans Male Medical Education Middle Aged multi-gene panels Mutation Neoplasms - ethnology Neoplasms - genetics Retrospective Studies Risk Assessment variants of uncertain significance
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