A bug’s life in the granuloma
The granuloma is the defining feature of the host response to infection with Mycobacterium tuberculosis (Mtb). Despite knowing of its existence for centuries, much remains unclear regarding the host and bacterial factors that contribute to granuloma formation, heterogeneity of presentation, and the...
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| Veröffentlicht in: | Seminars in immunopathology 2016-03, Vol.38 (2), p.213-220 |
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| creator | Martin, Constance J. Carey, Allison F. Fortune, Sarah M. |
| description | The granuloma is the defining feature of the host response to infection with
Mycobacterium tuberculosis
(Mtb). Despite knowing of its existence for centuries, much remains unclear regarding the host and bacterial factors that contribute to granuloma formation, heterogeneity of presentation, and the forces at play within. Mtb is highly adapted to life within the granuloma and employs many unique strategies to both create a niche within the host as well as survive the stresses imposed upon it. Adding to the complexity of the granuloma is the vast range of pathology observed, often within the same individual. Here, we explore some of the many ways in which Mtb crafts the immune response to its liking and builds a variety of granuloma features that contribute to its survival. We also consider the multitude of ways that Mtb is adapted to life in the granuloma and how variability in the deployment of these strategies may result in different fates for both the bacterium and the host. It is through better understanding of these complex interactions that we may begin to strategize novel approaches for tuberculosis treatments. |
| doi_str_mv | 10.1007/s00281-015-0533-1 |
| format | Article |
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Mycobacterium tuberculosis
(Mtb). Despite knowing of its existence for centuries, much remains unclear regarding the host and bacterial factors that contribute to granuloma formation, heterogeneity of presentation, and the forces at play within. Mtb is highly adapted to life within the granuloma and employs many unique strategies to both create a niche within the host as well as survive the stresses imposed upon it. Adding to the complexity of the granuloma is the vast range of pathology observed, often within the same individual. Here, we explore some of the many ways in which Mtb crafts the immune response to its liking and builds a variety of granuloma features that contribute to its survival. We also consider the multitude of ways that Mtb is adapted to life in the granuloma and how variability in the deployment of these strategies may result in different fates for both the bacterium and the host. It is through better understanding of these complex interactions that we may begin to strategize novel approaches for tuberculosis treatments.</description><identifier>ISSN: 1863-2297</identifier><identifier>EISSN: 1863-2300</identifier><identifier>DOI: 10.1007/s00281-015-0533-1</identifier><identifier>PMID: 26577238</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adaptation, Biological ; Animals ; Antigens, Bacterial - immunology ; Antitubercular Agents - pharmacology ; Antitubercular Agents - therapeutic use ; Biomedical and Life Sciences ; Biomedicine ; Disease Progression ; DNA Methylation ; Energy Metabolism ; Exosomes - metabolism ; Genetic Predisposition to Disease ; Granuloma - etiology ; Granuloma - metabolism ; Granuloma - pathology ; Host-Pathogen Interactions - immunology ; Humans ; Immune System - cytology ; Immune System - immunology ; Immune System - microbiology ; Immune System - pathology ; Immunology ; Internal Medicine ; Macrophages - immunology ; Macrophages - metabolism ; Macrophages - microbiology ; Macrophages - pathology ; Mycobacterium tuberculosis ; Mycobacterium tuberculosis - drug effects ; Mycobacterium tuberculosis - physiology ; Necrosis ; Oxidative Stress ; Phenotype ; Review ; Tuberculosis - complications ; Tuberculosis - metabolism ; Tuberculosis - microbiology ; Tuberculosis - pathology</subject><ispartof>Seminars in immunopathology, 2016-03, Vol.38 (2), p.213-220</ispartof><rights>Springer-Verlag Berlin Heidelberg 2015</rights><rights>Springer-Verlag Berlin Heidelberg 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c503t-fd1a441c48eb898ca4e169f46b41aa34f02d7ad66a0f7956a0edd11f09578fa13</citedby><cites>FETCH-LOGICAL-c503t-fd1a441c48eb898ca4e169f46b41aa34f02d7ad66a0f7956a0edd11f09578fa13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00281-015-0533-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00281-015-0533-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,313,314,776,780,788,881,27901,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26577238$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Martin, Constance J.</creatorcontrib><creatorcontrib>Carey, Allison F.</creatorcontrib><creatorcontrib>Fortune, Sarah M.</creatorcontrib><title>A bug’s life in the granuloma</title><title>Seminars in immunopathology</title><addtitle>Semin Immunopathol</addtitle><addtitle>Semin Immunopathol</addtitle><description>The granuloma is the defining feature of the host response to infection with
Mycobacterium tuberculosis
(Mtb). Despite knowing of its existence for centuries, much remains unclear regarding the host and bacterial factors that contribute to granuloma formation, heterogeneity of presentation, and the forces at play within. Mtb is highly adapted to life within the granuloma and employs many unique strategies to both create a niche within the host as well as survive the stresses imposed upon it. Adding to the complexity of the granuloma is the vast range of pathology observed, often within the same individual. Here, we explore some of the many ways in which Mtb crafts the immune response to its liking and builds a variety of granuloma features that contribute to its survival. We also consider the multitude of ways that Mtb is adapted to life in the granuloma and how variability in the deployment of these strategies may result in different fates for both the bacterium and the host. It is through better understanding of these complex interactions that we may begin to strategize novel approaches for tuberculosis treatments.</description><subject>Adaptation, Biological</subject><subject>Animals</subject><subject>Antigens, Bacterial - immunology</subject><subject>Antitubercular Agents - pharmacology</subject><subject>Antitubercular Agents - therapeutic use</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Disease Progression</subject><subject>DNA Methylation</subject><subject>Energy Metabolism</subject><subject>Exosomes - metabolism</subject><subject>Genetic Predisposition to Disease</subject><subject>Granuloma - etiology</subject><subject>Granuloma - metabolism</subject><subject>Granuloma - pathology</subject><subject>Host-Pathogen Interactions - immunology</subject><subject>Humans</subject><subject>Immune System - cytology</subject><subject>Immune System - immunology</subject><subject>Immune System - microbiology</subject><subject>Immune System - pathology</subject><subject>Immunology</subject><subject>Internal Medicine</subject><subject>Macrophages - immunology</subject><subject>Macrophages - metabolism</subject><subject>Macrophages - microbiology</subject><subject>Macrophages - pathology</subject><subject>Mycobacterium tuberculosis</subject><subject>Mycobacterium tuberculosis - drug effects</subject><subject>Mycobacterium tuberculosis - physiology</subject><subject>Necrosis</subject><subject>Oxidative Stress</subject><subject>Phenotype</subject><subject>Review</subject><subject>Tuberculosis - complications</subject><subject>Tuberculosis - metabolism</subject><subject>Tuberculosis - microbiology</subject><subject>Tuberculosis - pathology</subject><issn>1863-2297</issn><issn>1863-2300</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkctKxTAQhoMo3h_AjRbcuKnO5N6NIOINBDe6Dmmb1EpPq8mp4M7X8PV8Ens8F46C4GoC882fZD5C9hCOEUCdRACqMQUUKQjGUlwhm6glSykDWJ2faaY2yFaMTwBCMaHWyQaVQinK9CY5OEvyvvp8_4hJU3uX1G0yfnRJFWzbN93I7pA1b5vodmd1mzxcXtyfX6e3d1c352e3aSGAjVNfouUcC65drjNdWO5QZp7LnKO1jHugpbKllBa8ysRQXFkiesiE0t4i2yan09znPh-5snDtONjGPId6ZMOb6Wxtfnba-tFU3avhmnEt9RBwNAsI3Uvv4tiM6li4prGt6_poUCkpBYDE_6CgNYdsgh7-Qp-6PrTDJr6pDKigYqBwShWhizE4v3g3gpmYMlNTZjBlJqbMJHl_-cOLibmaAaBTIA6ttnJh6eo_U78A12mcww</recordid><startdate>20160301</startdate><enddate>20160301</enddate><creator>Martin, Constance J.</creator><creator>Carey, Allison F.</creator><creator>Fortune, Sarah M.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160301</creationdate><title>A bug’s life in the granuloma</title><author>Martin, Constance J. ; Carey, Allison F. ; Fortune, Sarah M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c503t-fd1a441c48eb898ca4e169f46b41aa34f02d7ad66a0f7956a0edd11f09578fa13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adaptation, Biological</topic><topic>Animals</topic><topic>Antigens, Bacterial - immunology</topic><topic>Antitubercular Agents - pharmacology</topic><topic>Antitubercular Agents - therapeutic use</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Disease Progression</topic><topic>DNA Methylation</topic><topic>Energy Metabolism</topic><topic>Exosomes - metabolism</topic><topic>Genetic Predisposition to Disease</topic><topic>Granuloma - etiology</topic><topic>Granuloma - metabolism</topic><topic>Granuloma - pathology</topic><topic>Host-Pathogen Interactions - immunology</topic><topic>Humans</topic><topic>Immune System - cytology</topic><topic>Immune System - immunology</topic><topic>Immune System - microbiology</topic><topic>Immune System - pathology</topic><topic>Immunology</topic><topic>Internal Medicine</topic><topic>Macrophages - immunology</topic><topic>Macrophages - metabolism</topic><topic>Macrophages - microbiology</topic><topic>Macrophages - pathology</topic><topic>Mycobacterium tuberculosis</topic><topic>Mycobacterium tuberculosis - drug effects</topic><topic>Mycobacterium tuberculosis - physiology</topic><topic>Necrosis</topic><topic>Oxidative Stress</topic><topic>Phenotype</topic><topic>Review</topic><topic>Tuberculosis - complications</topic><topic>Tuberculosis - metabolism</topic><topic>Tuberculosis - microbiology</topic><topic>Tuberculosis - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Martin, Constance J.</creatorcontrib><creatorcontrib>Carey, Allison F.</creatorcontrib><creatorcontrib>Fortune, Sarah M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Seminars in immunopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Martin, Constance J.</au><au>Carey, Allison F.</au><au>Fortune, Sarah M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A bug’s life in the granuloma</atitle><jtitle>Seminars in immunopathology</jtitle><stitle>Semin Immunopathol</stitle><addtitle>Semin Immunopathol</addtitle><date>2016-03-01</date><risdate>2016</risdate><volume>38</volume><issue>2</issue><spage>213</spage><epage>220</epage><pages>213-220</pages><issn>1863-2297</issn><eissn>1863-2300</eissn><abstract>The granuloma is the defining feature of the host response to infection with
Mycobacterium tuberculosis
(Mtb). Despite knowing of its existence for centuries, much remains unclear regarding the host and bacterial factors that contribute to granuloma formation, heterogeneity of presentation, and the forces at play within. Mtb is highly adapted to life within the granuloma and employs many unique strategies to both create a niche within the host as well as survive the stresses imposed upon it. Adding to the complexity of the granuloma is the vast range of pathology observed, often within the same individual. Here, we explore some of the many ways in which Mtb crafts the immune response to its liking and builds a variety of granuloma features that contribute to its survival. We also consider the multitude of ways that Mtb is adapted to life in the granuloma and how variability in the deployment of these strategies may result in different fates for both the bacterium and the host. It is through better understanding of these complex interactions that we may begin to strategize novel approaches for tuberculosis treatments.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>26577238</pmid><doi>10.1007/s00281-015-0533-1</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Seminars in immunopathology, 2016-03, Vol.38 (2), p.213-220 |
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| subjects | Adaptation, Biological Animals Antigens, Bacterial - immunology Antitubercular Agents - pharmacology Antitubercular Agents - therapeutic use Biomedical and Life Sciences Biomedicine Disease Progression DNA Methylation Energy Metabolism Exosomes - metabolism Genetic Predisposition to Disease Granuloma - etiology Granuloma - metabolism Granuloma - pathology Host-Pathogen Interactions - immunology Humans Immune System - cytology Immune System - immunology Immune System - microbiology Immune System - pathology Immunology Internal Medicine Macrophages - immunology Macrophages - metabolism Macrophages - microbiology Macrophages - pathology Mycobacterium tuberculosis Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - physiology Necrosis Oxidative Stress Phenotype Review Tuberculosis - complications Tuberculosis - metabolism Tuberculosis - microbiology Tuberculosis - pathology |
| title | A bug’s life in the granuloma |
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