Actin‐like 6A predicts poor prognosis of hepatocellular carcinoma and promotes metastasis and epithelial‐mesenchymal transition

Hepatocellular carcinoma (HCC) is one of the most lethal cancers worldwide because of metastasis. Epithelial‐mesenchymal transition (EMT) is widely considered to be crucial to the invasion‐metastasis cascade during cancer progression. Actin‐like 6A (ACTL6A) is initially verified important for cell p...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2016-04, Vol.63 (4), p.1256-1271
Hauptverfasser:	Xiao, Shuai, Chang, Rui‐Min, Yang, Ming‐Yang, Lei, Xiong, Liu, Xiao, Gao, Wen‐Bin, Xiao, Jing‐Lei, Yang, Lian‐Yue
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Actins - genetics Adult Aged Analysis of Variance Animals Biopsy, Needle Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - mortality Carcinoma, Hepatocellular - pathology Cell adhesion & migration Cell migration Cell proliferation Chromosomal Proteins, Non-Histone - genetics Disease Models, Animal DNA-Binding Proteins - genetics Ectopic expression Epithelial-Mesenchymal Transition - genetics Female Gene Expression Regulation, Neoplastic Hepatobiliary Malignancies Hepatocellular carcinoma Hepatology Humans Immunohistochemistry Liver cancer Liver Neoplasms - genetics Liver Neoplasms - mortality Liver Neoplasms - pathology Male Medical prognosis Mesenchyme Metastases Metastasis Mice Middle Aged Multivariate Analysis Neoplasm Invasiveness - pathology Neoplasm Metastasis - genetics Notch1 protein Phenylglycine Predictive Value of Tests Prognosis Random Allocation Survival Analysis Transcriptional Activation Tumor Cells, Cultured Up-Regulation Xenografts
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