Diabetes Medications: Impact on Inflammation and Wound Healing

Abstract Chronic wounds are a common complication in patients with diabetes that often lead to amputation. These non-healing wounds are described as being stuck in a persistent inflammatory state characterized by accumulation of pro-inflammatory macrophages, cytokines and proteases. Some medications...

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Veröffentlicht in:	Journal of diabetes and its complications 2016-05, Vol.30 (4), p.746-752
Hauptverfasser:	Salazar, Jay J, Ennis, William J, Koh, Timothy J
Format:	Artikel
Sprache:	eng
Schlagworte:	Amputation Angiogenesis Animals Anti-Inflammatory Agents, Non-Steroidal - adverse effects Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Cell growth Clinical trials Cytokines Diabetes Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - immunology Diabetes Mellitus, Type 2 - metabolism Diabetic Angiopathies - complications Diabetic Angiopathies - immunology Diabetic Angiopathies - metabolism Diabetic Angiopathies - prevention & control Dipeptidyl-Peptidase IV Inhibitors - adverse effects Dipeptidyl-Peptidase IV Inhibitors - therapeutic use Disease control Disease prevention DPP-4 inhibitor Endocrinology & Metabolism Genotype & phenotype Heart failure Humans Hypoglycemic Agents - adverse effects Hypoglycemic Agents - therapeutic use Inflammation Insulin Insulin - adverse effects Insulin - metabolism Insulin - therapeutic use Insulin Resistance Insulin Secretion Insulin-like growth factors Metformin Models, Biological Mortality Studies Sulfonylurea Thiazolidinedione Tumor necrosis factor-TNF Vasculitis - complications Vasculitis - immunology Vasculitis - metabolism Vasculitis - prevention & control Wound healing Wound Healing - drug effects
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