Translational Pharmacokinetic‐Pharmacodynamic Modeling and Simulation: Optimizing 5‐Fluorouracil Dosing in Children With Pediatric Ependymoma

We previously investigated novel therapies for pediatric ependymoma and found 5‐fluorouracil (5‐FU) i.v. bolus increased survival in a representative mouse model. However, without a quantitative framework to derive clinical dosing recommendations, we devised a translational pharmacokinetic‐pharmacod...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	CPT: pharmacometrics and systems pharmacology 2016-04, Vol.5 (4), p.211-221
Hauptverfasser:	Daryani, VM, Patel, YT, Tagen, M, Turner, DC, Carcaboso, AM, Atkinson, JM, Gajjar, A, Gilbertson, RJ, Wright, KD, Stewart, CF
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimetabolites, Antineoplastic - administration & dosage Antimetabolites, Antineoplastic - blood Antimetabolites, Antineoplastic - pharmacokinetics Blood Proteins - metabolism Cancer therapies Chemotherapy Child Child, Preschool Clinical trials Colorectal cancer Computer Simulation Disease Drug Dosage Calculations Drug dosages Ependymoma - blood Ependymoma - drug therapy Ependymoma - metabolism Fluorouracil - administration & dosage Fluorouracil - blood Fluorouracil - pharmacokinetics Humans Mice Models, Biological Nonlinear Dynamics Original Parameter estimation Pediatrics Pharmacodynamics Pharmacokinetics Protein Binding Random Allocation Simulation Studies Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!