Hoxa10 null animals exhibit reduced platelet biogenesis

Summary The transcription factor HOXA10 is an important regulator of myelopoiesis. Engineered over‐expression of Hoxa10 in mice results in a myeloproliferative disorder that progresses to acute myeloid leukaemia (AML) over time, and in humans over‐expression is associated with poor outcomes in AML....

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Veröffentlicht in:	British journal of haematology 2016-04, Vol.173 (2), p.303-313
Hauptverfasser:	Konieczna, Iwona M., DeLuca, Teresa A., Eklund, Elizabeth A., Miller, William M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Coagulation - physiology Female Homeodomain Proteins - metabolism HOXA10 in vivo Male megakaryopoiesis Mice, Inbred C57BL Myelopoiesis - physiology Platelet Activation - physiology Platelet Count Platelets Reticulocytes - physiology Thrombocytopenia - etiology thrombopoiesis Thrombopoiesis - physiology
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