Supportive Family Environments Ameliorate the Link Between Racial Discrimination and Epigenetic Aging: A Replication Across Two Longitudinal Cohorts
This study tested the hypothesis that supportive family environments during adolescence buffer exposure to racial discrimination, reducing its impact on biological weathering and its manifestation in cellular aging. Perceived racial discrimination, support in the family environment, and confounder v...
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| Veröffentlicht in: | Psychological science 2016-04, Vol.27 (4), p.530-541 |
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| creator | Brody, Gene H. Miller, Gregory E. Yu, Tianyi Beach, Steven R. H. Chen, Edith |
| description | This study tested the hypothesis that supportive family environments during adolescence buffer exposure to racial discrimination, reducing its impact on biological weathering and its manifestation in cellular aging. Perceived racial discrimination, support in the family environment, and confounder variables were assessed for 3 consecutive years across adolescence in two independent cohorts of African American youth from rural Georgia. DNA was extracted from peripheral blood mononuclear cells collected during young adulthood. Patterns of methylation were used to index the epigenetic ages of these cells and the extent to which they differed from participants' chronological ages. Among youth in supportive family environments, exposure to higher levels of racial discrimination did not forecast greater epigenetic aging. Among youth in less supportive family environments, exposure to higher levels of racial discrimination did forecast greater epigenetic aging. The associations emerged independently of confounder variables, and the results were replicated across the two cohorts. |
| doi_str_mv | 10.1177/0956797615626703 |
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H. ; Chen, Edith</creator><creatorcontrib>Brody, Gene H. ; Miller, Gregory E. ; Yu, Tianyi ; Beach, Steven R. H. ; Chen, Edith</creatorcontrib><description>This study tested the hypothesis that supportive family environments during adolescence buffer exposure to racial discrimination, reducing its impact on biological weathering and its manifestation in cellular aging. Perceived racial discrimination, support in the family environment, and confounder variables were assessed for 3 consecutive years across adolescence in two independent cohorts of African American youth from rural Georgia. DNA was extracted from peripheral blood mononuclear cells collected during young adulthood. Patterns of methylation were used to index the epigenetic ages of these cells and the extent to which they differed from participants' chronological ages. Among youth in supportive family environments, exposure to higher levels of racial discrimination did not forecast greater epigenetic aging. Among youth in less supportive family environments, exposure to higher levels of racial discrimination did forecast greater epigenetic aging. The associations emerged independently of confounder variables, and the results were replicated across the two cohorts.</description><identifier>ISSN: 0956-7976</identifier><identifier>EISSN: 1467-9280</identifier><identifier>DOI: 10.1177/0956797615626703</identifier><identifier>PMID: 26917213</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Adolescent ; Adolescents ; African Americans ; African Americans - genetics ; Aging ; Blood ; Child development ; Deoxyribonucleic acid ; DNA ; DNA Methylation - genetics ; Environment ; Epigenesis, Genetic ; Epigenetics ; Families & family life ; Family ; Female ; Georgia ; Home environment ; Humans ; Leukocytes, Mononuclear ; Longitudinal Studies ; Male ; Racial discrimination ; Racism ; Rural communities ; Rural Population ; Teenagers ; United States ; Variables ; Young Adult ; Young adults ; Youth</subject><ispartof>Psychological science, 2016-04, Vol.27 (4), p.530-541</ispartof><rights>Copyright © 2016 Association for Psychological Science</rights><rights>The Author(s) 2016</rights><rights>The Author(s) 2016.</rights><rights>The Author(s) 2016 2016 Association for Psychological Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c376t-488f2222c2a3fe4d8dd69264a3f062a47109d1997acc08e726c14876354bde833</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/24763501$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/24763501$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,776,780,799,881,21799,27903,27904,33753,43600,43601,57995,58228</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26917213$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brody, Gene H.</creatorcontrib><creatorcontrib>Miller, Gregory E.</creatorcontrib><creatorcontrib>Yu, Tianyi</creatorcontrib><creatorcontrib>Beach, Steven R. H.</creatorcontrib><creatorcontrib>Chen, Edith</creatorcontrib><title>Supportive Family Environments Ameliorate the Link Between Racial Discrimination and Epigenetic Aging: A Replication Across Two Longitudinal Cohorts</title><title>Psychological science</title><addtitle>Psychol Sci</addtitle><description>This study tested the hypothesis that supportive family environments during adolescence buffer exposure to racial discrimination, reducing its impact on biological weathering and its manifestation in cellular aging. Perceived racial discrimination, support in the family environment, and confounder variables were assessed for 3 consecutive years across adolescence in two independent cohorts of African American youth from rural Georgia. DNA was extracted from peripheral blood mononuclear cells collected during young adulthood. Patterns of methylation were used to index the epigenetic ages of these cells and the extent to which they differed from participants' chronological ages. Among youth in supportive family environments, exposure to higher levels of racial discrimination did not forecast greater epigenetic aging. Among youth in less supportive family environments, exposure to higher levels of racial discrimination did forecast greater epigenetic aging. The associations emerged independently of confounder variables, and the results were replicated across the two cohorts.</description><subject>Adolescent</subject><subject>Adolescents</subject><subject>African Americans</subject><subject>African Americans - genetics</subject><subject>Aging</subject><subject>Blood</subject><subject>Child development</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA Methylation - genetics</subject><subject>Environment</subject><subject>Epigenesis, Genetic</subject><subject>Epigenetics</subject><subject>Families & family life</subject><subject>Family</subject><subject>Female</subject><subject>Georgia</subject><subject>Home environment</subject><subject>Humans</subject><subject>Leukocytes, Mononuclear</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Racial discrimination</subject><subject>Racism</subject><subject>Rural communities</subject><subject>Rural Population</subject><subject>Teenagers</subject><subject>United States</subject><subject>Variables</subject><subject>Young Adult</subject><subject>Young adults</subject><subject>Youth</subject><issn>0956-7976</issn><issn>1467-9280</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BHHNA</sourceid><recordid>eNqNkktv1DAUhSMEokNhzwZkiQ2bgF_xgwVSGKaANBJSKevIdTwZD4md2s5U_R_8YDyklFIJgTeWdb977HN8i-Ipgq8Q4vw1lBXjkjNUMcw4JPeKBaKMlxILeL9YHMrloX5UPIpxB_PihD0sjjCTiGNEFsX3L9M4-pDs3oATNdj-Cqzc3gbvBuNSBPVgeuuDSgakrQFr676BdyZdGuPAqdJW9eC9jTrYwTqVrHdAuRasRtsZZ5LVoO6s696AGpyasbd6ZmodfIzg7NKDtXedTVOb23uw9Nv8lvi4eLBRfTRPrvfj4uvJ6mz5sVx__vBpWa9LTThLJRVig_PSWJGNoa1oWyYxo_kEGVaUIyhbJCVXWkNhOGYaUcEZqeh5awQhx8XbWXeczgfT6uw4qL4ZsxsVrhqvbPNnxdlt0_l9Q3NzRVAWeHktEPzFZGJqhhyG6XvljJ9igwSpIGYCk3-jXEJJOIH_ocoFqigktMroizvozk8hR5kpSQjPKBOZgjP1M_ZgNjcWEWwOg9TcHaTc8vx2NDcNvyYnA-UMRNWZW7f-XfDZzO9i8uG3Hj38Rzb9A2AV2rQ</recordid><startdate>20160401</startdate><enddate>20160401</enddate><creator>Brody, Gene H.</creator><creator>Miller, Gregory E.</creator><creator>Yu, Tianyi</creator><creator>Beach, Steven R. H.</creator><creator>Chen, Edith</creator><general>SAGE Publications</general><general>SAGE PUBLICATIONS, INC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U4</scope><scope>8BJ</scope><scope>BHHNA</scope><scope>DWI</scope><scope>FQK</scope><scope>JBE</scope><scope>WZK</scope><scope>7X8</scope><scope>7TK</scope><scope>5PM</scope></search><sort><creationdate>20160401</creationdate><title>Supportive Family Environments Ameliorate the Link Between Racial Discrimination and Epigenetic Aging: A Replication Across Two Longitudinal Cohorts</title><author>Brody, Gene H. ; Miller, Gregory E. ; Yu, Tianyi ; Beach, Steven R. H. ; Chen, Edith</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c376t-488f2222c2a3fe4d8dd69264a3f062a47109d1997acc08e726c14876354bde833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adolescent</topic><topic>Adolescents</topic><topic>African Americans</topic><topic>African Americans - genetics</topic><topic>Aging</topic><topic>Blood</topic><topic>Child development</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA Methylation - genetics</topic><topic>Environment</topic><topic>Epigenesis, Genetic</topic><topic>Epigenetics</topic><topic>Families & family life</topic><topic>Family</topic><topic>Female</topic><topic>Georgia</topic><topic>Home environment</topic><topic>Humans</topic><topic>Leukocytes, Mononuclear</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Racial discrimination</topic><topic>Racism</topic><topic>Rural communities</topic><topic>Rural Population</topic><topic>Teenagers</topic><topic>United States</topic><topic>Variables</topic><topic>Young Adult</topic><topic>Young adults</topic><topic>Youth</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brody, Gene H.</creatorcontrib><creatorcontrib>Miller, Gregory E.</creatorcontrib><creatorcontrib>Yu, Tianyi</creatorcontrib><creatorcontrib>Beach, Steven R. 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H.</au><au>Chen, Edith</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Supportive Family Environments Ameliorate the Link Between Racial Discrimination and Epigenetic Aging: A Replication Across Two Longitudinal Cohorts</atitle><jtitle>Psychological science</jtitle><addtitle>Psychol Sci</addtitle><date>2016-04-01</date><risdate>2016</risdate><volume>27</volume><issue>4</issue><spage>530</spage><epage>541</epage><pages>530-541</pages><issn>0956-7976</issn><eissn>1467-9280</eissn><abstract>This study tested the hypothesis that supportive family environments during adolescence buffer exposure to racial discrimination, reducing its impact on biological weathering and its manifestation in cellular aging. Perceived racial discrimination, support in the family environment, and confounder variables were assessed for 3 consecutive years across adolescence in two independent cohorts of African American youth from rural Georgia. DNA was extracted from peripheral blood mononuclear cells collected during young adulthood. Patterns of methylation were used to index the epigenetic ages of these cells and the extent to which they differed from participants' chronological ages. Among youth in supportive family environments, exposure to higher levels of racial discrimination did not forecast greater epigenetic aging. Among youth in less supportive family environments, exposure to higher levels of racial discrimination did forecast greater epigenetic aging. The associations emerged independently of confounder variables, and the results were replicated across the two cohorts.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>26917213</pmid><doi>10.1177/0956797615626703</doi><tpages>12</tpages></addata></record> |
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| subjects | Adolescent Adolescents African Americans African Americans - genetics Aging Blood Child development Deoxyribonucleic acid DNA DNA Methylation - genetics Environment Epigenesis, Genetic Epigenetics Families & family life Family Female Georgia Home environment Humans Leukocytes, Mononuclear Longitudinal Studies Male Racial discrimination Racism Rural communities Rural Population Teenagers United States Variables Young Adult Young adults Youth |
| title | Supportive Family Environments Ameliorate the Link Between Racial Discrimination and Epigenetic Aging: A Replication Across Two Longitudinal Cohorts |
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