Metformin inhibits the prometastatic effect of sorafenib in hepatocellular carcinoma by upregulating the expression of TIP30

We previously found that a low dose of sorafenib had a prometastatic effect on hepatocellular carcinoma (HCC), which was caused by downregulation of TIP30 expression. More recently, metformin has been shown to have potential as a preventive and therapeutic agent for different cancers, including HCC....

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Veröffentlicht in:	Cancer science 2016-04, Vol.107 (4), p.507-513
Hauptverfasser:	Guo, Zhigui, Cao, Manqing, You, Abin, Gao, Junrong, Zhou, Hongyuan, Li, Huikai, Cui, Yunlong, Fang, Feng, Zhang, Wei, Song, Tianqiang, Li, Qiang, Zhu, Xiaolin, Sun, Huichuan, Zhang, Ti
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetyltransferases - biosynthesis Acetyltransferases - genetics AMP Animals Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - pathology Cell cycle Cell growth Cell Line, Tumor Cell Proliferation - drug effects Diabetes Experiments Gene expression Gene Expression Regulation, Neoplastic - drug effects Genotype & phenotype Hepatocellular carcinoma human TIP30 protein Humans Kinases Liver cancer Liver Neoplasms - drug therapy Liver Neoplasms - genetics Liver Neoplasms - pathology Lung cancer Lung Neoplasms - drug therapy Lung Neoplasms - genetics Lung Neoplasms - pathology Lung Neoplasms - secondary Medical prognosis Metastases Metastasis Metformin Metformin - administration & dosage Mice Neoplasm Invasiveness - genetics Neoplasm Metastasis Niacinamide - administration & dosage Niacinamide - adverse effects Niacinamide - analogs & derivatives Original Phenylurea Compounds - administration & dosage Phenylurea Compounds - adverse effects Protein kinase Signal Transduction Sorafenib Studies Survival Thioredoxin thioredoxins Thioredoxins - genetics Transcription Factors - biosynthesis Transcription Factors - genetics Tumors Xenograft Model Antitumor Assays
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