Insulin resistance is associated with altered amino acid metabolism and adipose tissue dysfunction in normoglycemic women

Insulin resistance is associated adiposity, but the mechanisms are not fully understood. In this study, we aimed to identify early metabolic alterations associated with insulin resistance in normoglycemic women with varying degree of adiposity. One-hundred and ten young and middle-aged women were di...

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Veröffentlicht in:	Scientific reports 2016-04, Vol.6 (1), p.24540-24540, Article 24540
Hauptverfasser:	Wiklund, Petri, Zhang, Xiaobo, Pekkala, Satu, Autio, Reija, Kong, Lingjia, Yang, Yifan, Keinänen-Kiukaanniemi, Sirkka, Alen, Markku, Cheng, Sulin
Format:	Artikel
Sprache:	eng
Schlagworte:	140/131 38/39 631/443/319 692/53/2423 Adipose tissue Adipose Tissue - metabolism Amino acids Amino Acids - metabolism Anthropometry Blood Glucose Body Composition DNA microarrays Dual energy X-ray absorptiometry Energy metabolism Female Gene Expression Gene regulation Humanities and Social Sciences Humans Inflammation - genetics Inflammation - metabolism Insulin Insulin Resistance Liver Magnetic resonance spectroscopy Metabolism Metabolites Mitochondria multidisciplinary Muscle, Skeletal - metabolism Musculoskeletal system NMR Nuclear magnetic resonance Phosphorylation Science Science (multidisciplinary) Signal Transduction Skeletal muscle Spectroscopy Spectrum analysis Subcutaneous Fat - metabolism
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