Sonic hedgehog delivery from self-assembled nanofiber hydrogels reduces the fibrotic response in models of erectile dysfunction

[Display omitted] Erectile dysfunction (ED) is a serious medical condition in which current treatments are ineffective in prostatectomy and diabetic patients, due to injury to the cavernous nerve (CN), which causes irreversible remodeling of the penis (decreased smooth muscle and increased collagen)...

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Veröffentlicht in:	Acta biomaterialia 2016-03, Vol.32, p.89-99
Hauptverfasser:	Choe, Shawn, Veliceasa, Dorina, Bond, Christopher W., Harrington, Daniel A., Stupp, Samuel I., McVary, Kevin T., Podlasek, Carol A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cavernous nerve injury Collagen Collagen - metabolism Collagens Diabetes Mellitus - physiopathology Disease Models, Animal Drug Delivery Systems Erectile Dysfunction - drug therapy Erectile Dysfunction - pathology Erectile Dysfunction - physiopathology Fibrosis Ganglia - drug effects Hedgehog Proteins - administration & dosage Hedgehog Proteins - therapeutic use Humans Hydrogels Hydrogels - chemistry Hydroxyproline - metabolism Immunohistochemistry Inhibition Injuries Male Nanofibers - chemistry Nanostructure Patients Penis Penis - drug effects Penis - innervation Penis - pathology Penis - physiopathology Peptides - pharmacology Prostatectomy Proteins Rats, Sprague-Dawley Self-assembling peptide amphiphile nanofiber hydrogels Sonic hedgehog Staining and Labeling Time Factors
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