Insulator dysfunction and oncogene activation in IDH mutant gliomas

An epigenetic mechanism in which gain-of-function IDH mutations promote gliomagenesis by disrupting chromosomal topology is presented, with IDH mutations causing the binding sites of the methylation-sensitive insulator CTCF to become hypermethylated; disruption of a CTCF boundary near the glioma onc...

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Veröffentlicht in:	Nature (London) 2016-01, Vol.529 (7584), p.110-114
Hauptverfasser:	Flavahan, William A., Drier, Yotam, Liau, Brian B., Gillespie, Shawn M., Venteicher, Andrew S., Stemmer-Rachamimov, Anat O., Suvà, Mario L., Bernstein, Bradley E.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/176 631/208/176/1988 631/67/1922 692/699/67 692/699/67/1922 Analysis Base Sequence Binding Sites Care and treatment CCCTC-Binding Factor Cell Cycle Proteins - metabolism Cell Proliferation - drug effects Cell Transformation, Neoplastic - drug effects Cells, Cultured Chromatin - drug effects Chromatin - genetics Chromatin - metabolism Chromosomal Proteins, Non-Histone - metabolism Cohesins Complications and side effects CpG Islands - genetics CRISPR-Cas Systems - genetics Deoxyribonucleic acid DNA DNA methylation DNA Methylation - drug effects DNA Methylation - genetics Down-Regulation - drug effects Enhancer Elements, Genetic - genetics Epigenesis, Genetic - drug effects Epigenetics Gene expression Gene Expression Regulation, Neoplastic - drug effects Genetic aspects Genomes Glioma - drug therapy Glioma - enzymology Glioma - genetics Glioma - pathology Gliomas Glutarates - metabolism Humanities and Social Sciences Humans Influence Insulation Insulator Elements - drug effects Insulator Elements - genetics Isocitrate Dehydrogenase - chemistry Isocitrate Dehydrogenase - genetics Isocitrate Dehydrogenase - metabolism letter Metabolites Methylation multidisciplinary Mutants Mutation Mutation - genetics Oncogenes Oncogenes - genetics Phenotype Platelet-derived growth factor Protein Binding Receptor, Platelet-Derived Growth Factor alpha - genetics Repressor Proteins - metabolism Science Topology Tumors Up-Regulation
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