Antileishmanial and Cytotoxic Activity of Some Highly Oxidized Abietane Diterpenoids from the Bald Cypress, Taxodium distichum

Two new compounds, namely, a para-benzoquinone ring-containing abietane (1) and a para-benzoquinone ring-containing 7,8-seco-abietane (2), and 14 other known highly oxidized abietane diterpenoids (3–16) were isolated from an extract prepared from the cones of Taxodium distichum, collected in central...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2016-03, Vol.79 (3), p.598-606
Hauptverfasser:	Naman, C. Benjamin, Gromovsky, Anthony D, Vela, Cory M, Fletcher, Joshua N, Gupta, Gaurav, Varikuti, Sanjay, Zhu, Xiaohua, Zywot, Emilia M, Chai, Heebyung, Werbovetz, Karl A, Satoskar, Abhay R, Kinghorn, A. Douglas
Format:	Artikel
Sprache:	eng
Schlagworte:	amastigotes Animals benzoquinones Benzoquinones - chemistry circular dichroism spectroscopy cytotoxicity Diterpenes, Abietane - chemistry Diterpenes, Abietane - isolation & purification Diterpenes, Abietane - pharmacology diterpenoids Inhibitory Concentration 50 intravenous injection Leishmania Leishmania donovani - drug effects liver Mice Molecular Structure nuclear magnetic resonance spectroscopy Nuclear Magnetic Resonance, Biomolecular Ohio Oxidation-Reduction parasites promastigotes Taxodium - chemistry Taxodium distichum
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