Curcumin/Melatonin Hybrid 5‑(4-Hydroxy-phenyl)-3-oxo-pentanoic Acid [2-(5-Methoxy‑1H‑indol-3-yl)-ethyl]-amide Ameliorates AD-Like Pathology in the APP/PS1 Mouse Model

In our efforts to develop hybrid compounds of curcumin and melatonin as potential disease-modifying agents for Alzheimer’s disease (AD), a potent lead hybrid compound, Z-CM-I-1, has been recently identified and biologically characterized in vitro. In this work, we report the in vivo effects of Z-CM-...

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Veröffentlicht in:	ACS chemical neuroscience 2015-08, Vol.6 (8), p.1393-1399
Hauptverfasser:	Gerenu, Gorka, Liu, Kai, Chojnacki, Jeremy E, Saathoff, John M, Martínez-Martín, Pablo, Perry, George, Zhu, Xiongwei, Lee, Hyoung-gon, Zhang, Shijun
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - drug therapy Alzheimer Disease - metabolism Alzheimer Disease - pathology Amyloid beta-Protein Precursor - genetics Amyloid beta-Protein Precursor - metabolism Animals Blotting, Western Brain - drug effects Brain - metabolism Brain - pathology Coumarins - pharmacology Disease Models, Animal Electron Transport Chain Complex Proteins - metabolism Female Immunohistochemistry Indoles - pharmacology Melatonin - pharmacology Mice, Transgenic Microglia - drug effects Microglia - metabolism Microglia - pathology Molecular Structure Mutation Neuroprotective Agents - pharmacology Oxidative Stress - drug effects Oxidative Stress - physiology Pentanoic Acids - pharmacology Plaque, Amyloid - drug therapy Plaque, Amyloid - metabolism Plaque, Amyloid - pathology Presenilin-1 - genetics Presenilin-1 - metabolism
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