Inhibiting bacterial toxins by channel blockage
Emergent rational drug design techniques explore individual properties of target biomolecules, small and macromolecule drug candidates, and the physical forces governing their interactions. In this minireview, we focus on the single-molecule biophysical studies of channel-forming bacterial toxins th...
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| Veröffentlicht in: | Pathogens and disease 2016-03, Vol.74 (2), p.ftv113 |
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| container_title | Pathogens and disease |
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| creator | Bezrukov, Sergey M. Nestorovich, Ekaterina M. |
| description | Emergent rational drug design techniques explore individual properties of target biomolecules, small and macromolecule drug candidates, and the physical forces governing their interactions. In this minireview, we focus on the single-molecule biophysical studies of channel-forming bacterial toxins that suggest new approaches for their inhibition. We discuss several examples of blockage of bacterial pore-forming and AB-type toxins by the tailor-made compounds. In the concluding remarks, the most effective rationally designed pore-blocking antitoxins are compared with the small-molecule inhibitors of ion-selective channels of neurophysiology.
This minireview summarizes recent single-molecule biophysical studies on channel-forming bacterial toxins that suggest new approaches for their inhibition.
Graphical Abstract Figure.
This minireview summarizes recent single-molecule biophysical studies on channel-forming bacterial toxins that suggest new approaches for their inhibition. |
| doi_str_mv | 10.1093/femspd/ftv113 |
| format | Article |
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This minireview summarizes recent single-molecule biophysical studies on channel-forming bacterial toxins that suggest new approaches for their inhibition.
Graphical Abstract Figure.
This minireview summarizes recent single-molecule biophysical studies on channel-forming bacterial toxins that suggest new approaches for their inhibition.</description><identifier>ISSN: 2049-632X</identifier><identifier>EISSN: 2049-632X</identifier><identifier>DOI: 10.1093/femspd/ftv113</identifier><identifier>PMID: 26656888</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Antitoxins - chemistry ; Antitoxins - classification ; Antitoxins - pharmacology ; Bacterial Toxins - antagonists & inhibitors ; Bacterial Toxins - chemistry ; Bacterial Toxins - classification ; Drug Design ; Drug Discovery ; Inhibitory Concentration 50 ; Minireview ; Porins - antagonists & inhibitors ; Porins - chemistry ; Porins - metabolism ; Structure-Activity Relationship</subject><ispartof>Pathogens and disease, 2016-03, Vol.74 (2), p.ftv113</ispartof><rights>FEMS 2015. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com 2015</rights><rights>FEMS 2015. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><rights>FEMS 2015. All rights reserved. For permissions, please e-mail: 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-9e239280e2abd7af7e00729ce2b4d2fd243e748f61ccc456bf39d9252cd2c8403</citedby><cites>FETCH-LOGICAL-c420t-9e239280e2abd7af7e00729ce2b4d2fd243e748f61ccc456bf39d9252cd2c8403</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830228/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830228/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,1598,27903,27904,53769,53771</link.rule.ids><linktorsrc>$$Uhttps://dx.doi.org/10.1093/femspd/ftv113$$EView_record_in_Oxford_University_Press$$FView_record_in_$$GOxford_University_Press</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26656888$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Sebo, Peter</contributor><creatorcontrib>Bezrukov, Sergey M.</creatorcontrib><creatorcontrib>Nestorovich, Ekaterina M.</creatorcontrib><title>Inhibiting bacterial toxins by channel blockage</title><title>Pathogens and disease</title><addtitle>Pathog Dis</addtitle><description>Emergent rational drug design techniques explore individual properties of target biomolecules, small and macromolecule drug candidates, and the physical forces governing their interactions. In this minireview, we focus on the single-molecule biophysical studies of channel-forming bacterial toxins that suggest new approaches for their inhibition. We discuss several examples of blockage of bacterial pore-forming and AB-type toxins by the tailor-made compounds. In the concluding remarks, the most effective rationally designed pore-blocking antitoxins are compared with the small-molecule inhibitors of ion-selective channels of neurophysiology.
This minireview summarizes recent single-molecule biophysical studies on channel-forming bacterial toxins that suggest new approaches for their inhibition.
Graphical Abstract Figure.
This minireview summarizes recent single-molecule biophysical studies on channel-forming bacterial toxins that suggest new approaches for their inhibition.</description><subject>Antitoxins - chemistry</subject><subject>Antitoxins - classification</subject><subject>Antitoxins - pharmacology</subject><subject>Bacterial Toxins - antagonists & inhibitors</subject><subject>Bacterial Toxins - chemistry</subject><subject>Bacterial Toxins - classification</subject><subject>Drug Design</subject><subject>Drug Discovery</subject><subject>Inhibitory Concentration 50</subject><subject>Minireview</subject><subject>Porins - antagonists & inhibitors</subject><subject>Porins - chemistry</subject><subject>Porins - metabolism</subject><subject>Structure-Activity Relationship</subject><issn>2049-632X</issn><issn>2049-632X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1Lw0AQhhdRbKk9epUcvcRuZjfJ7kWQ4keh4EXB27Kf7Wq6Cdm02H9vJFrqybnMwDzzDLwIXWb4JsOczJzdxMbMXLfLMnKCxoApTwsCb6dH8whNY3zHfbE8Y2VxjkZQFHnBGBuj2SKsvfKdD6tESd3Z1ssq6epPH2Ki9oleyxBslaiq1h9yZS_QmZNVtNOfPkGvD_cv86d0-fy4mN8tU00Bdym3QDgwbEEqU0pXWoxL4NqCogacAUpsSZkrMq01zQvlCDccctAGNKOYTNDt4G22amONtqFrZSWa1m9kuxe19OLvJvi1WNU7QRnBAKwXpINAt3WMrXWH2wyL7_DEEJ4Ywuv5q-OHB_o3qh64HoB62_zj-gJignwP</recordid><startdate>20160301</startdate><enddate>20160301</enddate><creator>Bezrukov, Sergey M.</creator><creator>Nestorovich, Ekaterina M.</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20160301</creationdate><title>Inhibiting bacterial toxins by channel blockage</title><author>Bezrukov, Sergey M. ; Nestorovich, Ekaterina M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-9e239280e2abd7af7e00729ce2b4d2fd243e748f61ccc456bf39d9252cd2c8403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Antitoxins - chemistry</topic><topic>Antitoxins - classification</topic><topic>Antitoxins - pharmacology</topic><topic>Bacterial Toxins - antagonists & inhibitors</topic><topic>Bacterial Toxins - chemistry</topic><topic>Bacterial Toxins - classification</topic><topic>Drug Design</topic><topic>Drug Discovery</topic><topic>Inhibitory Concentration 50</topic><topic>Minireview</topic><topic>Porins - antagonists & inhibitors</topic><topic>Porins - chemistry</topic><topic>Porins - metabolism</topic><topic>Structure-Activity Relationship</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bezrukov, Sergey M.</creatorcontrib><creatorcontrib>Nestorovich, Ekaterina M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Pathogens and disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Bezrukov, Sergey M.</au><au>Nestorovich, Ekaterina M.</au><au>Sebo, Peter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibiting bacterial toxins by channel blockage</atitle><jtitle>Pathogens and disease</jtitle><addtitle>Pathog Dis</addtitle><date>2016-03-01</date><risdate>2016</risdate><volume>74</volume><issue>2</issue><spage>ftv113</spage><pages>ftv113-</pages><issn>2049-632X</issn><eissn>2049-632X</eissn><abstract>Emergent rational drug design techniques explore individual properties of target biomolecules, small and macromolecule drug candidates, and the physical forces governing their interactions. In this minireview, we focus on the single-molecule biophysical studies of channel-forming bacterial toxins that suggest new approaches for their inhibition. We discuss several examples of blockage of bacterial pore-forming and AB-type toxins by the tailor-made compounds. In the concluding remarks, the most effective rationally designed pore-blocking antitoxins are compared with the small-molecule inhibitors of ion-selective channels of neurophysiology.
This minireview summarizes recent single-molecule biophysical studies on channel-forming bacterial toxins that suggest new approaches for their inhibition.
Graphical Abstract Figure.
This minireview summarizes recent single-molecule biophysical studies on channel-forming bacterial toxins that suggest new approaches for their inhibition.</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>26656888</pmid><doi>10.1093/femspd/ftv113</doi><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 2049-632X |
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| language | eng |
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| source | Oxford Journals Open Access Collection |
| subjects | Antitoxins - chemistry Antitoxins - classification Antitoxins - pharmacology Bacterial Toxins - antagonists & inhibitors Bacterial Toxins - chemistry Bacterial Toxins - classification Drug Design Drug Discovery Inhibitory Concentration 50 Minireview Porins - antagonists & inhibitors Porins - chemistry Porins - metabolism Structure-Activity Relationship |
| title | Inhibiting bacterial toxins by channel blockage |
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