Integrated genomic characterization of IDH1-mutant glioma malignant progression

Murat Günel and colleagues use an integrated genomic approach to analyze the malignant progression of IDH1 -mutant gliomas. They observe nonlinear clonal expansion of the original tumors and identify oncogenic pathways driving progression, including activation of MYC and RTK-RAS-PI3K pathways and ep...

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Veröffentlicht in:	Nature genetics 2016-01, Vol.48 (1), p.59-66
Hauptverfasser:	Bai, Hanwen, Harmancı, Akdes Serin, Erson-Omay, E Zeynep, Li, Jie, Coşkun, Süleyman, Simon, Matthias, Krischek, Boris, Özduman, Koray, Omay, S Bülent, Sorensen, Eric A, Turcan, Şevin, Bakırcığlu, Mehmet, Carrión-Grant, Geneive, Murray, Phillip B, Clark, Victoria E, Ercan-Sencicek, A Gulhan, Knight, James, Sencar, Leman, Altınok, Selin, Kaulen, Leon D, Gülez, Burcu, Timmer, Marco, Schramm, Johannes, Mishra-Gorur, Ketu, Henegariu, Octavian, Moliterno, Jennifer, Louvi, Angeliki, Chan, Timothy A, Tannheimer, Stacey L, Pamir, M Necmettin, Vortmeyer, Alexander O, Bilguvar, Kaya, Yasuno, Katsuhito, Günel, Murat
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 45 631/208/212/177 631/208/212/2019 631/208/514/1948 Agriculture Analysis Animal Genetics and Genomics Biomedicine Brain tumors Cancer Cancer genetics Cancer Research Cancer therapies Central nervous system Central Nervous System Neoplasms - genetics Central Nervous System Neoplasms - pathology Deoxyribonucleic acid Development and progression DNA DNA binding proteins DNA Methylation Drug testing Embryonic stem cells Embryonic Stem Cells - metabolism Epigenetic inheritance Epigenetics Forkhead Box Protein M1 Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism Gene Dosage Gene expression Gene Expression Regulation, Neoplastic Gene Function Genes Genes, myc Genetic testing Genomes Genomics Glioma - genetics Glioma - pathology Gliomas Human Genetics Humans Isocitrate Dehydrogenase - genetics Isocitrate Dehydrogenase - metabolism Kinases letter Medical prognosis Methylation Mutation Neurophysiology Phosphatidylinositol 3-Kinases - genetics Phosphatidylinositol 3-Kinases - metabolism Receptor, Notch1 - genetics Receptor, Notch1 - metabolism Stem cells Transcription (Genetics) Tumors
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