Emerin and histone deacetylase 3 (HDAC3) cooperatively regulate expression and nuclear positions of MyoD, Myf5, and Pax7 genes during myogenesis

The spatial organization of chromatin is critical in establishing cell-type dependent gene expression programs. The inner nuclear membrane protein emerin has been implicated in regulating global chromatin architecture. We show emerin associates with genomic loci of muscle differentiation promoting f...

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Veröffentlicht in:	Chromosome research 2013-12, Vol.21 (8), p.765-779
Hauptverfasser:	Demmerle, Justin, Koch, Adam J, Holaska, James M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Genetics and Genomics Animals Biomedical and Life Sciences catalytic activity Cell Biology Cell Differentiation Cell Line Cell Nucleus - genetics Cell Nucleus - metabolism Cell Proliferation Chromatin Chromatin - genetics Gene expression Gene Expression Regulation, Developmental genes Genetic Loci Genetic research histone deacetylase Histone Deacetylases - genetics Histone Deacetylases - metabolism Human Genetics Life Sciences loci membrane proteins Membrane Proteins - genetics Membrane Proteins - metabolism Mice muscle development Muscle Development - genetics Muscular system MyoD Protein - genetics MyoD Protein - metabolism Myogenesis Myogenic Regulatory Factor 5 - genetics Myogenic Regulatory Factor 5 - metabolism nuclear membrane Nuclear Proteins - genetics Nuclear Proteins - metabolism PAX7 Transcription Factor - genetics PAX7 Transcription Factor - metabolism Plant Genetics and Genomics Transcriptional Activation
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