ADAM17 Inhibitors Attenuate Corneal Epithelial Detachment Induced by Mustard Exposure

Sulfur mustard, nitrogen mustard (NM), and 2-chloroethyl ethyl sulfide all cause corneal injury with epithelial-stromal separation, differing only by degree. Injury can resolve in a few weeks or develop into chronic corneal problems. These vesicants induce microbullae at the epithelial-stromal junct...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2016-04, Vol.57 (4), p.1687-1698
Hauptverfasser:	DeSantis-Rodrigues, Andrea, Chang, Yoke-Chen, Hahn, Rita A, Po, Iris P, Zhou, Peihong, Lacey, C Jeffrey, Pillai, Abhilash, C Young, Sherri, Flowers, 2nd, Robert A, Gallo, Michael A, Laskin, Jeffrey D, Gerecke, Donald R, Svoboda, Kathy K H, Heindel, Ned D, Gordon, Marion K
Format:	Artikel
Sprache:	eng
Schlagworte:	ADAM Proteins - metabolism ADAM17 Protein Animals Blotting, Western Cells, Cultured Cornea Corneal Diseases - chemically induced Corneal Diseases - metabolism Corneal Diseases - pathology Corneal Stroma - drug effects Corneal Stroma - metabolism Corneal Stroma - pathology Epithelium, Corneal - drug effects Epithelium, Corneal - metabolism Epithelium, Corneal - pathology Humans Mechlorethamine - toxicity Rabbits Tomography, Optical Coherence Tumor Necrosis Factor-alpha
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