Uncertain outcomes: adjusting for misclassification in antimalarial efficacy studies

Evaluation of antimalarial efficacy is difficult because recurrent parasitaemia can be due to recrudescence or re-infection. PCR is used to differentiate between recrudescences and re-infections by comparing parasite allelic variants before and after treatment. However, PCR-corrected results are sus...

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Veröffentlicht in:	Epidemiology and infection 2011-04, Vol.139 (4), p.544-551
Hauptverfasser:	PORTER, K. A., BURCH, C. L., POOLE, C., JULIANO, J. J., COLE, S. R., MESHNICK, S. R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimalarials Antimalarials - administration & dosage Antiparasitic agents Biological and medical sciences Biomedical Research - methods False negative errors False positive errors False Positive Reactions Fundamental and applied biological sciences. Psychology Humans Infections Infectious diseases Malaria Malaria - drug therapy Medical cures Microbiology Normal distribution Parasitology - methods Patients Polymerase chain reaction Polymerase Chain Reaction - methods Probabilities Probability Recurrence Relapse Sampling errors Treatment Outcome
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