Albumin-glutaraldehyde glue for repair of superficial lung defect: an in vitro experiment
Albumin-glutaraldehyde glue gained a widespread acceptance in repair of superficial lung defects associated with alveolar air leaks (AAL). As its sealing efficacy has not yet been thoroughly corroborated by clinical studies, we sought to assess the properties of commercially available albumin-glutar...
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| Veröffentlicht in: | Journal of cardiothoracic surgery 2016-04, Vol.11 (1), p.63-63, Article 63 |
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| creator | Bures, Maximilian Höffler, Hans-Klaus Friedel, Godehard Kyriss, Thomas Boedeker, Enole Länger, Florian Zardo, Patrick Zhang, Ruoyu |
| description | Albumin-glutaraldehyde glue gained a widespread acceptance in repair of superficial lung defects associated with alveolar air leaks (AAL). As its sealing efficacy has not yet been thoroughly corroborated by clinical studies, we sought to assess the properties of commercially available albumin-glutaraldehyde glue (BioGlue™) in an in vitro lung model.
The lower lobe of freshly excised swine lung (n = 10) was intubated and ventilated. A focal superficial parenchymal defect (40 × 25 mm) was created on the inflated lung. AAL was assessed with increasing inspired tidal volume (TVi). After glue application, AAL was assessed until burst failure occurred. To evaluate glue elasticity, the length of defect was recorded in the inflated lung.
Superficial parenchymal defects resulted in AAL increasing with ascending TVi. Multiple linear regression analysis revealed strong correlation between AAL and maximal inspiratory pressure. There was one application error. At TVi = 400, 500, 600, 700, 800 and 900 ml, BioGlue™ achieved complete sealing in nine, six, five, four two and one specimens, respectively. Mean burst pressure was 38.0 ± 4.2 cmH2O. All sealant failures were cohesive. BioGlue™ allowed an expansion of covered lung defects of 1.5 ± 1.7 mm.
Our in vitro tests demonstrated a high sealing efficacy of BioGlue™ for repair of superficial lung defects. Due to the rigid nature, caution should be taken to use this kind of sealant in trapped lungs. |
| doi_str_mv | 10.1186/s13019-016-0443-x |
| format | Article |
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The lower lobe of freshly excised swine lung (n = 10) was intubated and ventilated. A focal superficial parenchymal defect (40 × 25 mm) was created on the inflated lung. AAL was assessed with increasing inspired tidal volume (TVi). After glue application, AAL was assessed until burst failure occurred. To evaluate glue elasticity, the length of defect was recorded in the inflated lung.
Superficial parenchymal defects resulted in AAL increasing with ascending TVi. Multiple linear regression analysis revealed strong correlation between AAL and maximal inspiratory pressure. There was one application error. At TVi = 400, 500, 600, 700, 800 and 900 ml, BioGlue™ achieved complete sealing in nine, six, five, four two and one specimens, respectively. Mean burst pressure was 38.0 ± 4.2 cmH2O. All sealant failures were cohesive. BioGlue™ allowed an expansion of covered lung defects of 1.5 ± 1.7 mm.
Our in vitro tests demonstrated a high sealing efficacy of BioGlue™ for repair of superficial lung defects. Due to the rigid nature, caution should be taken to use this kind of sealant in trapped lungs.</description><identifier>ISSN: 1749-8090</identifier><identifier>EISSN: 1749-8090</identifier><identifier>DOI: 10.1186/s13019-016-0443-x</identifier><identifier>PMID: 27072534</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Albumin ; Albumins - administration & dosage ; Analysis ; Animals ; Care and treatment ; Crosslinked polymers ; Diagnosis ; Glutaral - administration & dosage ; In Vitro Techniques ; Lung - surgery ; Models, Animal ; Postoperative Complications ; Pulmonary Surgical Procedures ; Set (Psychology) ; Swine ; Tissue Adhesives - administration & dosage ; Wound Healing</subject><ispartof>Journal of cardiothoracic surgery, 2016-04, Vol.11 (1), p.63-63, Article 63</ispartof><rights>COPYRIGHT 2016 BioMed Central Ltd.</rights><rights>Copyright BioMed Central 2016</rights><rights>Bures et al. 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c494t-2071f3107fee1d0066ce0130e82cc7d90794638b52ee67733c95ee464bee8cd23</citedby><cites>FETCH-LOGICAL-c494t-2071f3107fee1d0066ce0130e82cc7d90794638b52ee67733c95ee464bee8cd23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4828862/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4828862/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27072534$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bures, Maximilian</creatorcontrib><creatorcontrib>Höffler, Hans-Klaus</creatorcontrib><creatorcontrib>Friedel, Godehard</creatorcontrib><creatorcontrib>Kyriss, Thomas</creatorcontrib><creatorcontrib>Boedeker, Enole</creatorcontrib><creatorcontrib>Länger, Florian</creatorcontrib><creatorcontrib>Zardo, Patrick</creatorcontrib><creatorcontrib>Zhang, Ruoyu</creatorcontrib><title>Albumin-glutaraldehyde glue for repair of superficial lung defect: an in vitro experiment</title><title>Journal of cardiothoracic surgery</title><addtitle>J Cardiothorac Surg</addtitle><description>Albumin-glutaraldehyde glue gained a widespread acceptance in repair of superficial lung defects associated with alveolar air leaks (AAL). As its sealing efficacy has not yet been thoroughly corroborated by clinical studies, we sought to assess the properties of commercially available albumin-glutaraldehyde glue (BioGlue™) in an in vitro lung model.
The lower lobe of freshly excised swine lung (n = 10) was intubated and ventilated. A focal superficial parenchymal defect (40 × 25 mm) was created on the inflated lung. AAL was assessed with increasing inspired tidal volume (TVi). After glue application, AAL was assessed until burst failure occurred. To evaluate glue elasticity, the length of defect was recorded in the inflated lung.
Superficial parenchymal defects resulted in AAL increasing with ascending TVi. Multiple linear regression analysis revealed strong correlation between AAL and maximal inspiratory pressure. There was one application error. At TVi = 400, 500, 600, 700, 800 and 900 ml, BioGlue™ achieved complete sealing in nine, six, five, four two and one specimens, respectively. Mean burst pressure was 38.0 ± 4.2 cmH2O. All sealant failures were cohesive. BioGlue™ allowed an expansion of covered lung defects of 1.5 ± 1.7 mm.
Our in vitro tests demonstrated a high sealing efficacy of BioGlue™ for repair of superficial lung defects. Due to the rigid nature, caution should be taken to use this kind of sealant in trapped lungs.</description><subject>Albumin</subject><subject>Albumins - administration & dosage</subject><subject>Analysis</subject><subject>Animals</subject><subject>Care and treatment</subject><subject>Crosslinked polymers</subject><subject>Diagnosis</subject><subject>Glutaral - administration & dosage</subject><subject>In Vitro Techniques</subject><subject>Lung - surgery</subject><subject>Models, Animal</subject><subject>Postoperative Complications</subject><subject>Pulmonary Surgical Procedures</subject><subject>Set (Psychology)</subject><subject>Swine</subject><subject>Tissue Adhesives - administration & dosage</subject><subject>Wound Healing</subject><issn>1749-8090</issn><issn>1749-8090</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNptUktvFSEYJcbGPvQHuDEkbrqZFgYGGBcmN41VkyZudOGKcJmPWxoGrjDT3P57mdxa26aBhNc55-PAQeg9JWeUKnFeKCO0bwgVDeGcNbtX6IhK3jeK9OT1o_khOi7lhhDeMdK9QYetJLLtGD9Cv1dhPY8-NpswTyabMMD13QC4LgG7lHGGrfEZJ4fLvIXsvPUm4DDHDR7AgZ0-YROxj_jWTzlh2FWQHyFOb9GBM6HAu_vxBP26_PLz4ltz9ePr94vVVWN5z6emJZI6Rol0AHQgRAgLpPoC1Vorh57Ingum1l0LIKRkzPYdABd8DaDs0LIT9Hmvu53XIwy2lq429LbewuQ7nYzXT0-iv9abdKu5apUSi8DpvUBOf2Yokx59sRCCiZDmoqlUlHZLr9CPz6A3ac6x2quoXopu-ZD_qI0JoH10qda1i6hecd4z2bWiq6izF1C1DTB6myI4X_efEOieYHMqJYN78EiJXvKg93nQNQ96yYPeVc6Hx4_zwPgXAPYXA1GwMw</recordid><startdate>20160412</startdate><enddate>20160412</enddate><creator>Bures, Maximilian</creator><creator>Höffler, Hans-Klaus</creator><creator>Friedel, Godehard</creator><creator>Kyriss, Thomas</creator><creator>Boedeker, Enole</creator><creator>Länger, Florian</creator><creator>Zardo, Patrick</creator><creator>Zhang, Ruoyu</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7Z</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160412</creationdate><title>Albumin-glutaraldehyde glue for repair of superficial lung defect: an in vitro experiment</title><author>Bures, Maximilian ; Höffler, Hans-Klaus ; Friedel, Godehard ; Kyriss, Thomas ; Boedeker, Enole ; Länger, Florian ; Zardo, Patrick ; Zhang, Ruoyu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c494t-2071f3107fee1d0066ce0130e82cc7d90794638b52ee67733c95ee464bee8cd23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Albumin</topic><topic>Albumins - administration & dosage</topic><topic>Analysis</topic><topic>Animals</topic><topic>Care and treatment</topic><topic>Crosslinked polymers</topic><topic>Diagnosis</topic><topic>Glutaral - administration & dosage</topic><topic>In Vitro Techniques</topic><topic>Lung - surgery</topic><topic>Models, Animal</topic><topic>Postoperative Complications</topic><topic>Pulmonary Surgical Procedures</topic><topic>Set (Psychology)</topic><topic>Swine</topic><topic>Tissue Adhesives - administration & dosage</topic><topic>Wound Healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bures, Maximilian</creatorcontrib><creatorcontrib>Höffler, Hans-Klaus</creatorcontrib><creatorcontrib>Friedel, Godehard</creatorcontrib><creatorcontrib>Kyriss, Thomas</creatorcontrib><creatorcontrib>Boedeker, Enole</creatorcontrib><creatorcontrib>Länger, Florian</creatorcontrib><creatorcontrib>Zardo, Patrick</creatorcontrib><creatorcontrib>Zhang, Ruoyu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of cardiothoracic surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bures, Maximilian</au><au>Höffler, Hans-Klaus</au><au>Friedel, Godehard</au><au>Kyriss, Thomas</au><au>Boedeker, Enole</au><au>Länger, Florian</au><au>Zardo, Patrick</au><au>Zhang, Ruoyu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Albumin-glutaraldehyde glue for repair of superficial lung defect: an in vitro experiment</atitle><jtitle>Journal of cardiothoracic surgery</jtitle><addtitle>J Cardiothorac Surg</addtitle><date>2016-04-12</date><risdate>2016</risdate><volume>11</volume><issue>1</issue><spage>63</spage><epage>63</epage><pages>63-63</pages><artnum>63</artnum><issn>1749-8090</issn><eissn>1749-8090</eissn><abstract>Albumin-glutaraldehyde glue gained a widespread acceptance in repair of superficial lung defects associated with alveolar air leaks (AAL). As its sealing efficacy has not yet been thoroughly corroborated by clinical studies, we sought to assess the properties of commercially available albumin-glutaraldehyde glue (BioGlue™) in an in vitro lung model.
The lower lobe of freshly excised swine lung (n = 10) was intubated and ventilated. A focal superficial parenchymal defect (40 × 25 mm) was created on the inflated lung. AAL was assessed with increasing inspired tidal volume (TVi). After glue application, AAL was assessed until burst failure occurred. To evaluate glue elasticity, the length of defect was recorded in the inflated lung.
Superficial parenchymal defects resulted in AAL increasing with ascending TVi. Multiple linear regression analysis revealed strong correlation between AAL and maximal inspiratory pressure. There was one application error. At TVi = 400, 500, 600, 700, 800 and 900 ml, BioGlue™ achieved complete sealing in nine, six, five, four two and one specimens, respectively. Mean burst pressure was 38.0 ± 4.2 cmH2O. All sealant failures were cohesive. BioGlue™ allowed an expansion of covered lung defects of 1.5 ± 1.7 mm.
Our in vitro tests demonstrated a high sealing efficacy of BioGlue™ for repair of superficial lung defects. Due to the rigid nature, caution should be taken to use this kind of sealant in trapped lungs.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>27072534</pmid><doi>10.1186/s13019-016-0443-x</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Albumin Albumins - administration & dosage Analysis Animals Care and treatment Crosslinked polymers Diagnosis Glutaral - administration & dosage In Vitro Techniques Lung - surgery Models, Animal Postoperative Complications Pulmonary Surgical Procedures Set (Psychology) Swine Tissue Adhesives - administration & dosage Wound Healing |
| title | Albumin-glutaraldehyde glue for repair of superficial lung defect: an in vitro experiment |
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