Cysteamine, the natural metabolite of pantetheinase, shows specific activity against Plasmodium
In mice, loss of pantetheinase activity causes susceptibility to infection with Plasmodium chabaudi AS. Treatment of mice with the pantetheinase metabolite cysteamine reduces blood-stage replication of P. chabaudi and significantly increases survival. Similarly, a short exposure of Plasmodium to cys...
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| Veröffentlicht in: | Experimental parasitology 2010-08, Vol.125 (4), p.315-324 |
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| creator | Min-Oo, Gundula Ayi, Kodjo Bongfen, Silayuv E. Tam, Mifong Radovanovic, Irena Gauthier, Susan Santiago, Helton Rothfuchs, Antonio Gigliotti Roffê, Ester Sher, Alan Mullick, Alaka Fortin, Anny Stevenson, Mary M. Kain, Kevin C. Gros, Philippe |
| description | In mice, loss of pantetheinase activity causes susceptibility to infection with
Plasmodium chabaudi AS. Treatment of mice with the pantetheinase metabolite cysteamine reduces blood-stage replication of
P. chabaudi and significantly increases survival. Similarly, a short exposure of
Plasmodium to cysteamine
ex vivo is sufficient to suppress parasite infectivity
in vivo. This effect of cysteamine is specific and not observed with a related thiol (dimercaptosuccinic acid) or with the pantethine precursor of cysteamine. Also, cysteamine does not protect against infection with the parasite
Trypanosoma cruzi or the fungal pathogen
Candida albicans, suggesting cysteamine acts directly against the parasite and does not modulate host inflammatory response. Cysteamine exposure also blocks replication of
P. falciparum in vitro; moreover, these treated parasites show higher levels of intact hemoglobin. This study highlights the
in vivo action of cysteamine against
Plasmodium and provides further evidence for the involvement of pantetheinase in host response to this infection. |
| doi_str_mv | 10.1016/j.exppara.2010.02.009 |
| format | Article |
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Plasmodium chabaudi AS. Treatment of mice with the pantetheinase metabolite cysteamine reduces blood-stage replication of
P. chabaudi and significantly increases survival. Similarly, a short exposure of
Plasmodium to cysteamine
ex vivo is sufficient to suppress parasite infectivity
in vivo. This effect of cysteamine is specific and not observed with a related thiol (dimercaptosuccinic acid) or with the pantethine precursor of cysteamine. Also, cysteamine does not protect against infection with the parasite
Trypanosoma cruzi or the fungal pathogen
Candida albicans, suggesting cysteamine acts directly against the parasite and does not modulate host inflammatory response. Cysteamine exposure also blocks replication of
P. falciparum in vitro; moreover, these treated parasites show higher levels of intact hemoglobin. This study highlights the
in vivo action of cysteamine against
Plasmodium and provides further evidence for the involvement of pantetheinase in host response to this infection.</description><identifier>ISSN: 0014-4894</identifier><identifier>EISSN: 1090-2449</identifier><identifier>DOI: 10.1016/j.exppara.2010.02.009</identifier><identifier>PMID: 20219464</identifier><identifier>CODEN: EXPAAA</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Amidohydrolases - metabolism ; Animals ; Anti-parasitic ; Antimalarials - pharmacology ; Antimalarials - therapeutic use ; Apicomplexa ; Biological and medical sciences ; Candida albicans ; Candidiasis - drug therapy ; Chagas Disease - drug therapy ; Chloroquine - pharmacology ; Cysteamine ; Cysteamine - pharmacology ; Cysteamine - therapeutic use ; Cytokines - blood ; Cytokines - drug effects ; Dose-Response Relationship, Drug ; Erythrocytes - drug effects ; Erythrocytes - parasitology ; Female ; Fundamental and applied biological sciences. Psychology ; GPI-Linked Proteins ; Hemoglobins - metabolism ; Humans ; Life cycle. Host-agent relationship. Pathogenesis ; Malaria - drug therapy ; Malaria - parasitology ; Male ; Mice ; Mice, Inbred C57BL ; Mouse model ; Parasitemia - drug therapy ; Parasitemia - parasitology ; Plasmodium ; Plasmodium chabaudi ; Plasmodium chabaudi - drug effects ; Plasmodium falciparum - drug effects ; Plasmodium falciparum - metabolism ; Protozoa ; Trypanosoma cruzi ; Trypanosoma cruzi - drug effects</subject><ispartof>Experimental parasitology, 2010-08, Vol.125 (4), p.315-324</ispartof><rights>2010 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright (c) 2010 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c593t-ab0a3c4f37b9639cef9de8e35ddac7452d582201a7518896cdf6fe3eea7793bf3</citedby><cites>FETCH-LOGICAL-c593t-ab0a3c4f37b9639cef9de8e35ddac7452d582201a7518896cdf6fe3eea7793bf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0014489410000640$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23428415$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20219464$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Min-Oo, Gundula</creatorcontrib><creatorcontrib>Ayi, Kodjo</creatorcontrib><creatorcontrib>Bongfen, Silayuv E.</creatorcontrib><creatorcontrib>Tam, Mifong</creatorcontrib><creatorcontrib>Radovanovic, Irena</creatorcontrib><creatorcontrib>Gauthier, Susan</creatorcontrib><creatorcontrib>Santiago, Helton</creatorcontrib><creatorcontrib>Rothfuchs, Antonio Gigliotti</creatorcontrib><creatorcontrib>Roffê, Ester</creatorcontrib><creatorcontrib>Sher, Alan</creatorcontrib><creatorcontrib>Mullick, Alaka</creatorcontrib><creatorcontrib>Fortin, Anny</creatorcontrib><creatorcontrib>Stevenson, Mary M.</creatorcontrib><creatorcontrib>Kain, Kevin C.</creatorcontrib><creatorcontrib>Gros, Philippe</creatorcontrib><title>Cysteamine, the natural metabolite of pantetheinase, shows specific activity against Plasmodium</title><title>Experimental parasitology</title><addtitle>Exp Parasitol</addtitle><description>In mice, loss of pantetheinase activity causes susceptibility to infection with
Plasmodium chabaudi AS. Treatment of mice with the pantetheinase metabolite cysteamine reduces blood-stage replication of
P. chabaudi and significantly increases survival. Similarly, a short exposure of
Plasmodium to cysteamine
ex vivo is sufficient to suppress parasite infectivity
in vivo. This effect of cysteamine is specific and not observed with a related thiol (dimercaptosuccinic acid) or with the pantethine precursor of cysteamine. Also, cysteamine does not protect against infection with the parasite
Trypanosoma cruzi or the fungal pathogen
Candida albicans, suggesting cysteamine acts directly against the parasite and does not modulate host inflammatory response. Cysteamine exposure also blocks replication of
P. falciparum in vitro; moreover, these treated parasites show higher levels of intact hemoglobin. This study highlights the
in vivo action of cysteamine against
Plasmodium and provides further evidence for the involvement of pantetheinase in host response to this infection.</description><subject>Amidohydrolases - metabolism</subject><subject>Animals</subject><subject>Anti-parasitic</subject><subject>Antimalarials - pharmacology</subject><subject>Antimalarials - therapeutic use</subject><subject>Apicomplexa</subject><subject>Biological and medical sciences</subject><subject>Candida albicans</subject><subject>Candidiasis - drug therapy</subject><subject>Chagas Disease - drug therapy</subject><subject>Chloroquine - pharmacology</subject><subject>Cysteamine</subject><subject>Cysteamine - pharmacology</subject><subject>Cysteamine - therapeutic use</subject><subject>Cytokines - blood</subject><subject>Cytokines - drug effects</subject><subject>Dose-Response Relationship, Drug</subject><subject>Erythrocytes - drug effects</subject><subject>Erythrocytes - parasitology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GPI-Linked Proteins</subject><subject>Hemoglobins - metabolism</subject><subject>Humans</subject><subject>Life cycle. Host-agent relationship. Pathogenesis</subject><subject>Malaria - drug therapy</subject><subject>Malaria - parasitology</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mouse model</subject><subject>Parasitemia - drug therapy</subject><subject>Parasitemia - parasitology</subject><subject>Plasmodium</subject><subject>Plasmodium chabaudi</subject><subject>Plasmodium chabaudi - drug effects</subject><subject>Plasmodium falciparum - drug effects</subject><subject>Plasmodium falciparum - metabolism</subject><subject>Protozoa</subject><subject>Trypanosoma cruzi</subject><subject>Trypanosoma cruzi - drug effects</subject><issn>0014-4894</issn><issn>1090-2449</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2P0zAQhi0EYsvCTwDlgriQ4q809oUVqviSVoIDnK2JM966SuwQO4X-e7xqWeC0F4_keebVO_MS8pzRNaNs82a_xl_TBDOsOS1_lK8p1Q_IilFNay6lfkhWlDJZS6XlBXmS0p5SqhiXj8kFp5xpuZErYrbHlBFGH_B1lXdYBcjLDEM1YoYuDj5jFV01QchY2j5AKmDaxZ-pShNa77ytwGZ_8PlYwQ34kHL1dYA0xt4v41PyyMGQ8Nm5XpLvH95_236qr798_Lx9d13bRotcQ0dBWOlE2-mN0Bad7lGhaPoebCsb3jeKl0WhbZhSemN7t3EoEKFtteicuCRvT7rT0o3YWwy5bGGm2Y8wH00Eb_7vBL8zN_FgpOKqnKsIvDoLzPHHgimb0SeLwwAB45KMEsWYaMpzH9kKUa6sJC1kcyLtHFOa0d35YdTcpmj25pyiuU3RUG5KimXuxb_L3E39ia0AL88AJAuDmyFYn_5yQnIlWVO4qxOH5fQHj7NJ1mOw2PsZbTZ99PdY-Q3RUsDo</recordid><startdate>20100801</startdate><enddate>20100801</enddate><creator>Min-Oo, Gundula</creator><creator>Ayi, Kodjo</creator><creator>Bongfen, Silayuv E.</creator><creator>Tam, Mifong</creator><creator>Radovanovic, Irena</creator><creator>Gauthier, Susan</creator><creator>Santiago, Helton</creator><creator>Rothfuchs, Antonio Gigliotti</creator><creator>Roffê, Ester</creator><creator>Sher, Alan</creator><creator>Mullick, Alaka</creator><creator>Fortin, Anny</creator><creator>Stevenson, Mary M.</creator><creator>Kain, Kevin C.</creator><creator>Gros, Philippe</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>C1K</scope><scope>F1W</scope><scope>H95</scope><scope>H97</scope><scope>L.G</scope><scope>M7N</scope><scope>5PM</scope></search><sort><creationdate>20100801</creationdate><title>Cysteamine, the natural metabolite of pantetheinase, shows specific activity against Plasmodium</title><author>Min-Oo, Gundula ; Ayi, Kodjo ; Bongfen, Silayuv E. ; Tam, Mifong ; Radovanovic, Irena ; Gauthier, Susan ; Santiago, Helton ; Rothfuchs, Antonio Gigliotti ; Roffê, Ester ; Sher, Alan ; Mullick, Alaka ; Fortin, Anny ; Stevenson, Mary M. ; Kain, Kevin C. ; Gros, Philippe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c593t-ab0a3c4f37b9639cef9de8e35ddac7452d582201a7518896cdf6fe3eea7793bf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Amidohydrolases - metabolism</topic><topic>Animals</topic><topic>Anti-parasitic</topic><topic>Antimalarials - pharmacology</topic><topic>Antimalarials - therapeutic use</topic><topic>Apicomplexa</topic><topic>Biological and medical sciences</topic><topic>Candida albicans</topic><topic>Candidiasis - drug therapy</topic><topic>Chagas Disease - drug therapy</topic><topic>Chloroquine - pharmacology</topic><topic>Cysteamine</topic><topic>Cysteamine - pharmacology</topic><topic>Cysteamine - therapeutic use</topic><topic>Cytokines - blood</topic><topic>Cytokines - drug effects</topic><topic>Dose-Response Relationship, Drug</topic><topic>Erythrocytes - drug effects</topic><topic>Erythrocytes - parasitology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. 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Plasmodium chabaudi AS. Treatment of mice with the pantetheinase metabolite cysteamine reduces blood-stage replication of
P. chabaudi and significantly increases survival. Similarly, a short exposure of
Plasmodium to cysteamine
ex vivo is sufficient to suppress parasite infectivity
in vivo. This effect of cysteamine is specific and not observed with a related thiol (dimercaptosuccinic acid) or with the pantethine precursor of cysteamine. Also, cysteamine does not protect against infection with the parasite
Trypanosoma cruzi or the fungal pathogen
Candida albicans, suggesting cysteamine acts directly against the parasite and does not modulate host inflammatory response. Cysteamine exposure also blocks replication of
P. falciparum in vitro; moreover, these treated parasites show higher levels of intact hemoglobin. This study highlights the
in vivo action of cysteamine against
Plasmodium and provides further evidence for the involvement of pantetheinase in host response to this infection.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>20219464</pmid><doi>10.1016/j.exppara.2010.02.009</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Experimental parasitology, 2010-08, Vol.125 (4), p.315-324 |
| issn | 0014-4894 1090-2449 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4828244 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Amidohydrolases - metabolism Animals Anti-parasitic Antimalarials - pharmacology Antimalarials - therapeutic use Apicomplexa Biological and medical sciences Candida albicans Candidiasis - drug therapy Chagas Disease - drug therapy Chloroquine - pharmacology Cysteamine Cysteamine - pharmacology Cysteamine - therapeutic use Cytokines - blood Cytokines - drug effects Dose-Response Relationship, Drug Erythrocytes - drug effects Erythrocytes - parasitology Female Fundamental and applied biological sciences. Psychology GPI-Linked Proteins Hemoglobins - metabolism Humans Life cycle. Host-agent relationship. Pathogenesis Malaria - drug therapy Malaria - parasitology Male Mice Mice, Inbred C57BL Mouse model Parasitemia - drug therapy Parasitemia - parasitology Plasmodium Plasmodium chabaudi Plasmodium chabaudi - drug effects Plasmodium falciparum - drug effects Plasmodium falciparum - metabolism Protozoa Trypanosoma cruzi Trypanosoma cruzi - drug effects |
| title | Cysteamine, the natural metabolite of pantetheinase, shows specific activity against Plasmodium |
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