Structure and function of factor XI

Factor XI (FXI) is the zymogen of an enzyme (FXIa) that contributes to hemostasis by activating factor IX. Although bleeding associated with FXI deficiency is relatively mild, there has been resurgence of interest in FXI because of studies indicating it makes contributions to thrombosis and other pr...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Blood 2010-04, Vol.115 (13), p.2569-2577
Hauptverfasser:	Emsley, Jonas, McEwan, Paul A., Gailani, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Blood Coagulation Blood Platelets - metabolism Catalytic Domain Dimerization Enzyme Activation Evolution, Molecular Factor IX - chemistry Factor XI - antagonists & inhibitors Factor XI - chemistry Factor XI - genetics Factor XI - physiology Factor XI Deficiency - blood Factor XI Deficiency - genetics Forecasting Hematologic and hematopoietic diseases Humans Medical sciences Models, Molecular Mutation Platelet Membrane Glycoproteins - physiology Prekallikrein - chemistry Prekallikrein - genetics Protein Binding Protein Conformation Protein Interaction Mapping Protein Structure, Tertiary Review Structure-Activity Relationship
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!