Exogenous DNA Loading into Extracellular Vesicles via Electroporation is Size-Dependent and Enables Limited Gene Delivery

Extracellular vesicles (EVs) hold immense promise for utilization as biotherapeutics and drug delivery vehicles due to their nature as biological nanoparticles that facilitate intercellular molecular transport. Specifically, EVs have been identified as natural carriers of nucleic acids, sparking int...

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Veröffentlicht in:	Molecular pharmaceutics 2015-10, Vol.12 (10), p.3650-3657
Hauptverfasser:	Lamichhane, Tek N, Raiker, Rahul S, Jay, Steven M
Format:	Artikel
Sprache:	eng
Schlagworte:	DNA - administration & dosage Electroporation - methods Extracellular Vesicles - metabolism Gene Transfer Techniques HEK293 Cells - metabolism Humans Mesenchymal Stromal Cells - metabolism
Online-Zugang:	Volltext
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