A beneficial tumor microenvironment in oropharyngeal squamous cell carcinoma is characterized by a high T cell and low IL-17+ cell frequency
Patients with HPV-positive oropharyngeal squamous cell carcinomas (OPSCCs) have a better prognosis than patients with non-HPV-induced OPSCC. The role of the immune response in this phenomenon is yet unclear. We studied the number of T cells, regulatory T cells (Tregs), T helper 17 (Th17) cells and I...
Gespeichert in:
| Veröffentlicht in: | Cancer Immunology, Immunotherapy Immunotherapy, 2016-04, Vol.65 (4), p.393-403 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 403 |
|---|---|
| container_issue | 4 |
| container_start_page | 393 |
| container_title | Cancer Immunology, Immunotherapy |
| container_volume | 65 |
| creator | Punt, Simone Dronkers, Emilie A. C. Welters, Marij J. P. Goedemans, Renske Koljenović, Senada Bloemena, Elisabeth Snijders, Peter J. F. Gorter, Arko van der Burg, Sjoerd H. de Jong, Robert J. Baatenburg Jordanova, Ekaterina S. |
| description | Patients with HPV-positive oropharyngeal squamous cell carcinomas (OPSCCs) have a better prognosis than patients with non-HPV-induced OPSCC. The role of the immune response in this phenomenon is yet unclear. We studied the number of T cells, regulatory T cells (Tregs), T helper 17 (Th17) cells and IL-17
+
non-T cells (mainly granulocytes) in matched HPV-positive and HPV-negative OPSCC cases (
n
= 162). Furthermore, the production of IFN-γ and IL-17 by tumor-infiltrating T cells was analyzed. The number of tumor-infiltrating T cells and Tregs was higher in HPV-positive than HPV-negative OPSCC (
p
|
| doi_str_mv | 10.1007/s00262-016-1805-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4826411</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1779881624</sourcerecordid><originalsourceid>FETCH-LOGICAL-c442t-283fba758424a6f5c05b17865a4be9f3c2ece3c06aa509ecbd3aa50cf8ad3a333</originalsourceid><addsrcrecordid>eNp9kU1v1DAQhi0EokvhB3BBPiKhgL-SOBekquKj0kpcytmaeCe7rhJ7a29Kl9_Aj2ZWKRVcOHk088zrmXkZey3FeylE-6EIoRpVCdlU0oq6un_CVtJoythaPmUroY2oWiHMGXtRyg0FSnTdc3amGtt12toV-3XBe4w4BB9g5Id5SplPweeE8S7kFCeMBx4iTzntd5CPcYvEldsZpjQX7nEcuYfsQ0wT8EAZosAfMIefuOH9kQPfhe2OXy8sxA0f0w9-ta5k-27JDRlvZ4z--JI9G2As-OrhPWffP3-6vvxarb99ubq8WFfeGHWolNVDD21tjTLQDLUXdS9b29RgeuwG7RV61F40ALXo0PcbfYr8YIEirfU5-7jo7ud-wo2nHTOMbp_DRCu6BMH9W4lh57bpzhmrGiMlCbx9EMiJRi8HN4Vy2gUi0lmcbNvOWtkoQ6hcULppKRmHx2-kcCcX3eKiIxfdyUV3Tz1v_p7vseOPbQSoBShUIkuyu0lzjnSz_6j-BkaurFA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1779881624</pqid></control><display><type>article</type><title>A beneficial tumor microenvironment in oropharyngeal squamous cell carcinoma is characterized by a high T cell and low IL-17+ cell frequency</title><source>MEDLINE</source><source>PubMed Central</source><source>SpringerLink Journals - AutoHoldings</source><creator>Punt, Simone ; Dronkers, Emilie A. C. ; Welters, Marij J. P. ; Goedemans, Renske ; Koljenović, Senada ; Bloemena, Elisabeth ; Snijders, Peter J. F. ; Gorter, Arko ; van der Burg, Sjoerd H. ; de Jong, Robert J. Baatenburg ; Jordanova, Ekaterina S.</creator><creatorcontrib>Punt, Simone ; Dronkers, Emilie A. C. ; Welters, Marij J. P. ; Goedemans, Renske ; Koljenović, Senada ; Bloemena, Elisabeth ; Snijders, Peter J. F. ; Gorter, Arko ; van der Burg, Sjoerd H. ; de Jong, Robert J. Baatenburg ; Jordanova, Ekaterina S.</creatorcontrib><description>Patients with HPV-positive oropharyngeal squamous cell carcinomas (OPSCCs) have a better prognosis than patients with non-HPV-induced OPSCC. The role of the immune response in this phenomenon is yet unclear. We studied the number of T cells, regulatory T cells (Tregs), T helper 17 (Th17) cells and IL-17
+
non-T cells (mainly granulocytes) in matched HPV-positive and HPV-negative OPSCC cases (
n
= 162). Furthermore, the production of IFN-γ and IL-17 by tumor-infiltrating T cells was analyzed. The number of tumor-infiltrating T cells and Tregs was higher in HPV-positive than HPV-negative OPSCC (
p
< 0.0001). In contrast, HPV-negative OPSCC contained significantly higher numbers of IL-17
+
non-T cells (
p
< 0.0001). Although a high number of intra-tumoral T cells showed a trend toward improved survival of all OPSCC patients, their prognostic effect in patients with a low number of intra-tumoral IL-17
+
non-T cells was significant with regard to disease-specific (
p
= 0.033) and disease-free survival (
p
= 0.012). This suggests that a high frequency of IL-17
+
non-T cells was related to a poor immune response, which was further supported by the observation that a high number of T cells was correlated with improved disease-free survival in the HPV-positive OPSCC (
p
= 0.008). In addition, we detected a minor Th17 cell population. However, T cells obtained from HPV-positive OPSCC produced significantly more IL-17 than those from HPV-negative tumors (
p
= 0.006). The improved prognosis of HPV-positive OPSCC is thus correlated with higher numbers of tumor-infiltrating T cells, more active Th17 cells and lower numbers of IL-17
+
non-T cells.</description><identifier>ISSN: 0340-7004</identifier><identifier>EISSN: 1432-0851</identifier><identifier>DOI: 10.1007/s00262-016-1805-x</identifier><identifier>PMID: 26899388</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Cancer Research ; Carcinoma, Squamous Cell - complications ; Carcinoma, Squamous Cell - immunology ; CD3 Complex - immunology ; CD3 Complex - metabolism ; Female ; Forkhead Transcription Factors - immunology ; Forkhead Transcription Factors - metabolism ; Granulocytes - immunology ; Granulocytes - metabolism ; Humans ; Immunology ; Interleukin-17 - immunology ; Interleukin-17 - metabolism ; Kaplan-Meier Estimate ; Lymphocyte Count ; Male ; Medicine ; Medicine & Public Health ; Microscopy, Confocal ; Middle Aged ; Oncology ; Original ; Original Article ; Oropharyngeal Neoplasms - complications ; Oropharyngeal Neoplasms - immunology ; Papillomaviridae - immunology ; Papillomavirus Infections - complications ; Papillomavirus Infections - immunology ; Papillomavirus Infections - virology ; T-Lymphocytes - immunology ; T-Lymphocytes - metabolism ; T-Lymphocytes, Regulatory - immunology ; T-Lymphocytes, Regulatory - metabolism ; Th17 Cells - immunology ; Th17 Cells - metabolism ; Tumor Microenvironment - immunology</subject><ispartof>Cancer Immunology, Immunotherapy, 2016-04, Vol.65 (4), p.393-403</ispartof><rights>The Author(s) 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-283fba758424a6f5c05b17865a4be9f3c2ece3c06aa509ecbd3aa50cf8ad3a333</citedby><cites>FETCH-LOGICAL-c442t-283fba758424a6f5c05b17865a4be9f3c2ece3c06aa509ecbd3aa50cf8ad3a333</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826411/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826411/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,41487,42556,51318,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26899388$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Punt, Simone</creatorcontrib><creatorcontrib>Dronkers, Emilie A. C.</creatorcontrib><creatorcontrib>Welters, Marij J. P.</creatorcontrib><creatorcontrib>Goedemans, Renske</creatorcontrib><creatorcontrib>Koljenović, Senada</creatorcontrib><creatorcontrib>Bloemena, Elisabeth</creatorcontrib><creatorcontrib>Snijders, Peter J. F.</creatorcontrib><creatorcontrib>Gorter, Arko</creatorcontrib><creatorcontrib>van der Burg, Sjoerd H.</creatorcontrib><creatorcontrib>de Jong, Robert J. Baatenburg</creatorcontrib><creatorcontrib>Jordanova, Ekaterina S.</creatorcontrib><title>A beneficial tumor microenvironment in oropharyngeal squamous cell carcinoma is characterized by a high T cell and low IL-17+ cell frequency</title><title>Cancer Immunology, Immunotherapy</title><addtitle>Cancer Immunol Immunother</addtitle><addtitle>Cancer Immunol Immunother</addtitle><description>Patients with HPV-positive oropharyngeal squamous cell carcinomas (OPSCCs) have a better prognosis than patients with non-HPV-induced OPSCC. The role of the immune response in this phenomenon is yet unclear. We studied the number of T cells, regulatory T cells (Tregs), T helper 17 (Th17) cells and IL-17
+
non-T cells (mainly granulocytes) in matched HPV-positive and HPV-negative OPSCC cases (
n
= 162). Furthermore, the production of IFN-γ and IL-17 by tumor-infiltrating T cells was analyzed. The number of tumor-infiltrating T cells and Tregs was higher in HPV-positive than HPV-negative OPSCC (
p
< 0.0001). In contrast, HPV-negative OPSCC contained significantly higher numbers of IL-17
+
non-T cells (
p
< 0.0001). Although a high number of intra-tumoral T cells showed a trend toward improved survival of all OPSCC patients, their prognostic effect in patients with a low number of intra-tumoral IL-17
+
non-T cells was significant with regard to disease-specific (
p
= 0.033) and disease-free survival (
p
= 0.012). This suggests that a high frequency of IL-17
+
non-T cells was related to a poor immune response, which was further supported by the observation that a high number of T cells was correlated with improved disease-free survival in the HPV-positive OPSCC (
p
= 0.008). In addition, we detected a minor Th17 cell population. However, T cells obtained from HPV-positive OPSCC produced significantly more IL-17 than those from HPV-negative tumors (
p
= 0.006). The improved prognosis of HPV-positive OPSCC is thus correlated with higher numbers of tumor-infiltrating T cells, more active Th17 cells and lower numbers of IL-17
+
non-T cells.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Cancer Research</subject><subject>Carcinoma, Squamous Cell - complications</subject><subject>Carcinoma, Squamous Cell - immunology</subject><subject>CD3 Complex - immunology</subject><subject>CD3 Complex - metabolism</subject><subject>Female</subject><subject>Forkhead Transcription Factors - immunology</subject><subject>Forkhead Transcription Factors - metabolism</subject><subject>Granulocytes - immunology</subject><subject>Granulocytes - metabolism</subject><subject>Humans</subject><subject>Immunology</subject><subject>Interleukin-17 - immunology</subject><subject>Interleukin-17 - metabolism</subject><subject>Kaplan-Meier Estimate</subject><subject>Lymphocyte Count</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Microscopy, Confocal</subject><subject>Middle Aged</subject><subject>Oncology</subject><subject>Original</subject><subject>Original Article</subject><subject>Oropharyngeal Neoplasms - complications</subject><subject>Oropharyngeal Neoplasms - immunology</subject><subject>Papillomaviridae - immunology</subject><subject>Papillomavirus Infections - complications</subject><subject>Papillomavirus Infections - immunology</subject><subject>Papillomavirus Infections - virology</subject><subject>T-Lymphocytes - immunology</subject><subject>T-Lymphocytes - metabolism</subject><subject>T-Lymphocytes, Regulatory - immunology</subject><subject>T-Lymphocytes, Regulatory - metabolism</subject><subject>Th17 Cells - immunology</subject><subject>Th17 Cells - metabolism</subject><subject>Tumor Microenvironment - immunology</subject><issn>0340-7004</issn><issn>1432-0851</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><recordid>eNp9kU1v1DAQhi0EokvhB3BBPiKhgL-SOBekquKj0kpcytmaeCe7rhJ7a29Kl9_Aj2ZWKRVcOHk088zrmXkZey3FeylE-6EIoRpVCdlU0oq6un_CVtJoythaPmUroY2oWiHMGXtRyg0FSnTdc3amGtt12toV-3XBe4w4BB9g5Id5SplPweeE8S7kFCeMBx4iTzntd5CPcYvEldsZpjQX7nEcuYfsQ0wT8EAZosAfMIefuOH9kQPfhe2OXy8sxA0f0w9-ta5k-27JDRlvZ4z--JI9G2As-OrhPWffP3-6vvxarb99ubq8WFfeGHWolNVDD21tjTLQDLUXdS9b29RgeuwG7RV61F40ALXo0PcbfYr8YIEirfU5-7jo7ud-wo2nHTOMbp_DRCu6BMH9W4lh57bpzhmrGiMlCbx9EMiJRi8HN4Vy2gUi0lmcbNvOWtkoQ6hcULppKRmHx2-kcCcX3eKiIxfdyUV3Tz1v_p7vseOPbQSoBShUIkuyu0lzjnSz_6j-BkaurFA</recordid><startdate>20160401</startdate><enddate>20160401</enddate><creator>Punt, Simone</creator><creator>Dronkers, Emilie A. C.</creator><creator>Welters, Marij J. P.</creator><creator>Goedemans, Renske</creator><creator>Koljenović, Senada</creator><creator>Bloemena, Elisabeth</creator><creator>Snijders, Peter J. F.</creator><creator>Gorter, Arko</creator><creator>van der Burg, Sjoerd H.</creator><creator>de Jong, Robert J. Baatenburg</creator><creator>Jordanova, Ekaterina S.</creator><general>Springer Berlin Heidelberg</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160401</creationdate><title>A beneficial tumor microenvironment in oropharyngeal squamous cell carcinoma is characterized by a high T cell and low IL-17+ cell frequency</title><author>Punt, Simone ; Dronkers, Emilie A. C. ; Welters, Marij J. P. ; Goedemans, Renske ; Koljenović, Senada ; Bloemena, Elisabeth ; Snijders, Peter J. F. ; Gorter, Arko ; van der Burg, Sjoerd H. ; de Jong, Robert J. Baatenburg ; Jordanova, Ekaterina S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-283fba758424a6f5c05b17865a4be9f3c2ece3c06aa509ecbd3aa50cf8ad3a333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Cancer Research</topic><topic>Carcinoma, Squamous Cell - complications</topic><topic>Carcinoma, Squamous Cell - immunology</topic><topic>CD3 Complex - immunology</topic><topic>CD3 Complex - metabolism</topic><topic>Female</topic><topic>Forkhead Transcription Factors - immunology</topic><topic>Forkhead Transcription Factors - metabolism</topic><topic>Granulocytes - immunology</topic><topic>Granulocytes - metabolism</topic><topic>Humans</topic><topic>Immunology</topic><topic>Interleukin-17 - immunology</topic><topic>Interleukin-17 - metabolism</topic><topic>Kaplan-Meier Estimate</topic><topic>Lymphocyte Count</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Microscopy, Confocal</topic><topic>Middle Aged</topic><topic>Oncology</topic><topic>Original</topic><topic>Original Article</topic><topic>Oropharyngeal Neoplasms - complications</topic><topic>Oropharyngeal Neoplasms - immunology</topic><topic>Papillomaviridae - immunology</topic><topic>Papillomavirus Infections - complications</topic><topic>Papillomavirus Infections - immunology</topic><topic>Papillomavirus Infections - virology</topic><topic>T-Lymphocytes - immunology</topic><topic>T-Lymphocytes - metabolism</topic><topic>T-Lymphocytes, Regulatory - immunology</topic><topic>T-Lymphocytes, Regulatory - metabolism</topic><topic>Th17 Cells - immunology</topic><topic>Th17 Cells - metabolism</topic><topic>Tumor Microenvironment - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Punt, Simone</creatorcontrib><creatorcontrib>Dronkers, Emilie A. C.</creatorcontrib><creatorcontrib>Welters, Marij J. P.</creatorcontrib><creatorcontrib>Goedemans, Renske</creatorcontrib><creatorcontrib>Koljenović, Senada</creatorcontrib><creatorcontrib>Bloemena, Elisabeth</creatorcontrib><creatorcontrib>Snijders, Peter J. F.</creatorcontrib><creatorcontrib>Gorter, Arko</creatorcontrib><creatorcontrib>van der Burg, Sjoerd H.</creatorcontrib><creatorcontrib>de Jong, Robert J. Baatenburg</creatorcontrib><creatorcontrib>Jordanova, Ekaterina S.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancer Immunology, Immunotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Punt, Simone</au><au>Dronkers, Emilie A. C.</au><au>Welters, Marij J. P.</au><au>Goedemans, Renske</au><au>Koljenović, Senada</au><au>Bloemena, Elisabeth</au><au>Snijders, Peter J. F.</au><au>Gorter, Arko</au><au>van der Burg, Sjoerd H.</au><au>de Jong, Robert J. Baatenburg</au><au>Jordanova, Ekaterina S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A beneficial tumor microenvironment in oropharyngeal squamous cell carcinoma is characterized by a high T cell and low IL-17+ cell frequency</atitle><jtitle>Cancer Immunology, Immunotherapy</jtitle><stitle>Cancer Immunol Immunother</stitle><addtitle>Cancer Immunol Immunother</addtitle><date>2016-04-01</date><risdate>2016</risdate><volume>65</volume><issue>4</issue><spage>393</spage><epage>403</epage><pages>393-403</pages><issn>0340-7004</issn><eissn>1432-0851</eissn><abstract>Patients with HPV-positive oropharyngeal squamous cell carcinomas (OPSCCs) have a better prognosis than patients with non-HPV-induced OPSCC. The role of the immune response in this phenomenon is yet unclear. We studied the number of T cells, regulatory T cells (Tregs), T helper 17 (Th17) cells and IL-17
+
non-T cells (mainly granulocytes) in matched HPV-positive and HPV-negative OPSCC cases (
n
= 162). Furthermore, the production of IFN-γ and IL-17 by tumor-infiltrating T cells was analyzed. The number of tumor-infiltrating T cells and Tregs was higher in HPV-positive than HPV-negative OPSCC (
p
< 0.0001). In contrast, HPV-negative OPSCC contained significantly higher numbers of IL-17
+
non-T cells (
p
< 0.0001). Although a high number of intra-tumoral T cells showed a trend toward improved survival of all OPSCC patients, their prognostic effect in patients with a low number of intra-tumoral IL-17
+
non-T cells was significant with regard to disease-specific (
p
= 0.033) and disease-free survival (
p
= 0.012). This suggests that a high frequency of IL-17
+
non-T cells was related to a poor immune response, which was further supported by the observation that a high number of T cells was correlated with improved disease-free survival in the HPV-positive OPSCC (
p
= 0.008). In addition, we detected a minor Th17 cell population. However, T cells obtained from HPV-positive OPSCC produced significantly more IL-17 than those from HPV-negative tumors (
p
= 0.006). The improved prognosis of HPV-positive OPSCC is thus correlated with higher numbers of tumor-infiltrating T cells, more active Th17 cells and lower numbers of IL-17
+
non-T cells.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>26899388</pmid><doi>10.1007/s00262-016-1805-x</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0340-7004 |
| ispartof | Cancer Immunology, Immunotherapy, 2016-04, Vol.65 (4), p.393-403 |
| issn | 0340-7004 1432-0851 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4826411 |
| source | MEDLINE; PubMed Central; SpringerLink Journals - AutoHoldings |
| subjects | Adult Aged Aged, 80 and over Cancer Research Carcinoma, Squamous Cell - complications Carcinoma, Squamous Cell - immunology CD3 Complex - immunology CD3 Complex - metabolism Female Forkhead Transcription Factors - immunology Forkhead Transcription Factors - metabolism Granulocytes - immunology Granulocytes - metabolism Humans Immunology Interleukin-17 - immunology Interleukin-17 - metabolism Kaplan-Meier Estimate Lymphocyte Count Male Medicine Medicine & Public Health Microscopy, Confocal Middle Aged Oncology Original Original Article Oropharyngeal Neoplasms - complications Oropharyngeal Neoplasms - immunology Papillomaviridae - immunology Papillomavirus Infections - complications Papillomavirus Infections - immunology Papillomavirus Infections - virology T-Lymphocytes - immunology T-Lymphocytes - metabolism T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism Th17 Cells - immunology Th17 Cells - metabolism Tumor Microenvironment - immunology |
| title | A beneficial tumor microenvironment in oropharyngeal squamous cell carcinoma is characterized by a high T cell and low IL-17+ cell frequency |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-11T20%3A28%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20beneficial%20tumor%20microenvironment%20in%20oropharyngeal%20squamous%20cell%20carcinoma%20is%20characterized%20by%20a%20high%20T%20cell%20and%20low%20IL-17+%20cell%20frequency&rft.jtitle=Cancer%20Immunology,%20Immunotherapy&rft.au=Punt,%20Simone&rft.date=2016-04-01&rft.volume=65&rft.issue=4&rft.spage=393&rft.epage=403&rft.pages=393-403&rft.issn=0340-7004&rft.eissn=1432-0851&rft_id=info:doi/10.1007/s00262-016-1805-x&rft_dat=%3Cproquest_pubme%3E1779881624%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1779881624&rft_id=info:pmid/26899388&rfr_iscdi=true |