A beneficial tumor microenvironment in oropharyngeal squamous cell carcinoma is characterized by a high T cell and low IL-17+ cell frequency

Patients with HPV-positive oropharyngeal squamous cell carcinomas (OPSCCs) have a better prognosis than patients with non-HPV-induced OPSCC. The role of the immune response in this phenomenon is yet unclear. We studied the number of T cells, regulatory T cells (Tregs), T helper 17 (Th17) cells and I...

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Veröffentlicht in:	Cancer Immunology, Immunotherapy Immunotherapy, 2016-04, Vol.65 (4), p.393-403
Hauptverfasser:	Punt, Simone, Dronkers, Emilie A. C., Welters, Marij J. P., Goedemans, Renske, Koljenović, Senada, Bloemena, Elisabeth, Snijders, Peter J. F., Gorter, Arko, van der Burg, Sjoerd H., de Jong, Robert J. Baatenburg, Jordanova, Ekaterina S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Cancer Research Carcinoma, Squamous Cell - complications Carcinoma, Squamous Cell - immunology CD3 Complex - immunology CD3 Complex - metabolism Female Forkhead Transcription Factors - immunology Forkhead Transcription Factors - metabolism Granulocytes - immunology Granulocytes - metabolism Humans Immunology Interleukin-17 - immunology Interleukin-17 - metabolism Kaplan-Meier Estimate Lymphocyte Count Male Medicine Medicine & Public Health Microscopy, Confocal Middle Aged Oncology Original Original Article Oropharyngeal Neoplasms - complications Oropharyngeal Neoplasms - immunology Papillomaviridae - immunology Papillomavirus Infections - complications Papillomavirus Infections - immunology Papillomavirus Infections - virology T-Lymphocytes - immunology T-Lymphocytes - metabolism T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism Th17 Cells - immunology Th17 Cells - metabolism Tumor Microenvironment - immunology
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Zusammenfassung:	Patients with HPV-positive oropharyngeal squamous cell carcinomas (OPSCCs) have a better prognosis than patients with non-HPV-induced OPSCC. The role of the immune response in this phenomenon is yet unclear. We studied the number of T cells, regulatory T cells (Tregs), T helper 17 (Th17) cells and IL-17 + non-T cells (mainly granulocytes) in matched HPV-positive and HPV-negative OPSCC cases ( n = 162). Furthermore, the production of IFN-γ and IL-17 by tumor-infiltrating T cells was analyzed. The number of tumor-infiltrating T cells and Tregs was higher in HPV-positive than HPV-negative OPSCC ( p
ISSN:	0340-7004 1432-0851
DOI:	10.1007/s00262-016-1805-x