p130Cas scaffold protein regulates ErbB2 stability by altering breast cancer cell sensitivity to autophagy

Overexpression of the ErbB2/HER2 receptor tyrosine kinase occurs in up to 20% of human breast cancers and correlates with aggressive disease. Several efficacious targeted therapies, including antibodies and kinase inhibitors, have been developed but the occurring of resistance to these agents is oft...

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Veröffentlicht in:	Oncotarget 2016-01, Vol.7 (4), p.4442-4453
Hauptverfasser:	Bisaro, Brigitte, Sciortino, Marianna, Colombo, Shana, Camacho Leal, Maria Pilar, Costamagna, Andrea, Castellano, Isabella, Montemurro, Filippo, Rossi, Valentina, Valabrega, Giorgio, Turco, Emilia, Defilippi, Paola, Cabodi, Sara
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Apoptosis Autophagy Blotting, Western Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Breast Neoplasms - pathology Carcinoma, Ductal, Breast - drug therapy Carcinoma, Ductal, Breast - metabolism Carcinoma, Ductal, Breast - pathology Carcinoma, Lobular - drug therapy Carcinoma, Lobular - metabolism Carcinoma, Lobular - pathology Cell Proliferation Crk-Associated Substrate Protein - genetics Crk-Associated Substrate Protein - metabolism Drug Resistance, Neoplasm Female Humans Immunoenzyme Techniques Immunoprecipitation Neoplasm Recurrence, Local - drug therapy Neoplasm Recurrence, Local - metabolism Neoplasm Recurrence, Local - pathology Neoplasm Staging Prognosis Protein Stability Real-Time Polymerase Chain Reaction Receptor, ErbB-2 - chemistry Receptor, ErbB-2 - genetics Receptor, ErbB-2 - metabolism Research Paper Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Trastuzumab - pharmacology Tumor Cells, Cultured
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