The serotonin system in autism spectrum disorder: From biomarker to animal models
Highlights • Elevated whole-blood serotonin is a well-replicated biomarker found in 25% of children with autism spectrum disorder. • In addition to a well-defined role in adults, serotonin modulates neurodevelopment, including sensory development. • The serotonin transporter gene is associated with...
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| Veröffentlicht in: | Neuroscience 2016-05, Vol.321, p.24-41 |
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| creator | Muller, C.L Anacker, A.M.J Veenstra-VanderWeele, J |
| description | Highlights • Elevated whole-blood serotonin is a well-replicated biomarker found in 25% of children with autism spectrum disorder. • In addition to a well-defined role in adults, serotonin modulates neurodevelopment, including sensory development. • The serotonin transporter gene is associated with whole-blood serotonin levels and with autism risk but only in males. • A serotonin transporter knock-in mouse shows elevated blood serotonin levels and altered social and repetitive behavior. • The serotonin system is a prime candidate for treatment development in children with this heritable biomarker. |
| doi_str_mv | 10.1016/j.neuroscience.2015.11.010 |
| format | Article |
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Anacker, A.M.J ; Veenstra-VanderWeele, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c542t-be0373957d544ce3c34e8ec0d10671dabbbc8d844f6fbf00ac98d578908955d43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Autism Spectrum Disorder - diagnosis</topic><topic>Autism Spectrum Disorder - genetics</topic><topic>Autism Spectrum Disorder - metabolism</topic><topic>Biomarkers - metabolism</topic><topic>Brain - metabolism</topic><topic>Disease Models, Animal</topic><topic>Female</topic><topic>genetic</topic><topic>Genetic Association Studies</topic><topic>Genetic Linkage</topic><topic>Humans</topic><topic>Male</topic><topic>Mice, Mutant Strains</topic><topic>monoamine</topic><topic>multisensory</topic><topic>neurodevelopment</topic><topic>Neurology</topic><topic>platelet</topic><topic>reuptake</topic><topic>Serotonin - metabolism</topic><topic>Serotonin Plasma Membrane Transport Proteins - genetics</topic><topic>Serotonin Plasma Membrane Transport Proteins - metabolism</topic><topic>Sex Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Muller, C.L</creatorcontrib><creatorcontrib>Anacker, A.M.J</creatorcontrib><creatorcontrib>Veenstra-VanderWeele, J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Muller, C.L</au><au>Anacker, A.M.J</au><au>Veenstra-VanderWeele, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The serotonin system in autism spectrum disorder: From biomarker to animal models</atitle><jtitle>Neuroscience</jtitle><addtitle>Neuroscience</addtitle><date>2016-05-03</date><risdate>2016</risdate><volume>321</volume><spage>24</spage><epage>41</epage><pages>24-41</pages><issn>0306-4522</issn><eissn>1873-7544</eissn><abstract>Highlights • Elevated whole-blood serotonin is a well-replicated biomarker found in 25% of children with autism spectrum disorder. • In addition to a well-defined role in adults, serotonin modulates neurodevelopment, including sensory development. • The serotonin transporter gene is associated with whole-blood serotonin levels and with autism risk but only in males. • A serotonin transporter knock-in mouse shows elevated blood serotonin levels and altered social and repetitive behavior. • The serotonin system is a prime candidate for treatment development in children with this heritable biomarker.</abstract><cop>United States</cop><pub>Elsevier Ltd</pub><pmid>26577932</pmid><doi>10.1016/j.neuroscience.2015.11.010</doi><tpages>18</tpages><orcidid>https://orcid.org/0000-0002-6349-1076</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Autism Spectrum Disorder - diagnosis Autism Spectrum Disorder - genetics Autism Spectrum Disorder - metabolism Biomarkers - metabolism Brain - metabolism Disease Models, Animal Female genetic Genetic Association Studies Genetic Linkage Humans Male Mice, Mutant Strains monoamine multisensory neurodevelopment Neurology platelet reuptake Serotonin - metabolism Serotonin Plasma Membrane Transport Proteins - genetics Serotonin Plasma Membrane Transport Proteins - metabolism Sex Factors |
| title | The serotonin system in autism spectrum disorder: From biomarker to animal models |
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