Ulocuplumab (BMS-936564 / MDX1338): a fully human anti-CXCR4 antibody induces cell death in chronic lymphocytic leukemia mediated through a reactive oxygen species-dependent pathway

The CXCR4 receptor (Chemokine C-X-C motif receptor 4) is highly expressed in different hematological malignancies including chronic lymphocytic leukemia (CLL). The CXCR4 ligand (CXCL12) stimulates CXCR4 promoting cell survival and proliferation, and may contribute to the tropism of leukemia cells to...

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Veröffentlicht in:	Oncotarget 2016-01, Vol.7 (3), p.2809-2822
Hauptverfasser:	Kashyap, Manoj K, Kumar, Deepak, Jones, Harrison, Amaya-Chanaga, Carlos I, Choi, Michael Y, Melo-Cardenas, Johanna, Ale-Ali, Amine, Kuhne, Michelle R, Sabbatini, Peter, Cohen, Lewis J, Shelat, Suresh G, Rassenti, Laura Z, Kipps, Thomas J, Cardarelli, Pina M, Castro, Januario E
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Antineoplastic Agents - pharmacology Apoptosis - drug effects Cell Movement - drug effects Cell Proliferation Cell Survival Chemokine CXCL12 - biosynthesis Chemokine CXCL12 - metabolism Enzyme Activation - drug effects Heterocyclic Compounds - pharmacology Humans Imino Furanoses - pharmacology Jurkat Cells Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy Leukocytes, Mononuclear Pyrimidinones - pharmacology Reactive Oxygen Species - metabolism Receptors, CXCR4 - antagonists & inhibitors Receptors, CXCR4 - biosynthesis Research Paper Tumor Cells, Cultured Tumor Suppressor Protein p53 - metabolism
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