Secular Trends in the Incidence of Cholangiocarcinoma in the USA and the Impact of Misclassification
Background and Aims It has been reported that the incidence of intrahepatic cholangiocarcinoma (ICC) has increased in the USA, while extrahepatic cholangiocarcinoma (ECC) has decreased or remained stable. However, neither the recent trends nor the effects of the misclassification of Klatskin tumors...
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| Veröffentlicht in: | Digestive diseases and sciences 2014-12, Vol.59 (12), p.3103-3110 |
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| creator | Tyson, Gia L. Ilyas, Jawad A. Duan, Zhigang Green, Linda K. Younes, Mamoun El-Serag, Hashem B. Davila, Jessica A. |
| description | Background and Aims
It has been reported that the incidence of intrahepatic cholangiocarcinoma (ICC) has increased in the USA, while extrahepatic cholangiocarcinoma (ECC) has decreased or remained stable. However, neither the recent trends nor the effects of the misclassification of Klatskin tumors are known.
Methods
Using the Surveillance, Epidemiology, and End Results program databases, we calculated the average annual age-adjusted incidence rates (AA-IRs) of ICC and ECC in 4-year time periods (1992–1995, 1996–1999, 2000–2003, 2004–2007). These AA-IRs were calculated with misclassified as well as correctly classified Klatskin tumors. AA-IRs were also calculated based on age, sex, and race. Multivariable Poisson regression models were used to evaluate the secular trends of ICC and ECC.
Results
The AA-IR of ICC was 0.92 in 1992–1995 and 0.93 in 2004–2007, while the AA-IR of ECC increased from 0.70 in 1992–1995 to 0.95 in 2004–2007. There was no significant trend in AA-IR of ICC (
p
= 0.07), while there was a significant increase in ECC across the 4-year time periods (
p
|
| doi_str_mv | 10.1007/s10620-014-3276-2 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4823008</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A712944169</galeid><sourcerecordid>A712944169</sourcerecordid><originalsourceid>FETCH-LOGICAL-c636t-cda988b1636972760a87f1044492575485a63ffb7ddd6c5b131d0e88e70fbd323</originalsourceid><addsrcrecordid>eNqFkltrFTEUhYMo9lj9Ab7IgC--TM09mRfhcPBSqPjQ9jlkcjknZSY5JjOC_94M09ZWFAkkIfnWYu_NAuA1gmcIQvG-IMgxbCGiLcGCt_gJ2CAmSIsZl0_BBiJe7wjxE_CilBsIYScQfw5OMMOQci43wF46Mw86N1fZRVuaEJvp4JrzaIJ10bgm-WZ3SIOO-5CMzibENOo77Ppy2-hoV8l41GZa-K-hmEGXEnwwegopvgTPvB6Ke3V7noLrTx-vdl_ai2-fz3fbi9ZwwqfWWN1J2deieSdqP1BL4RGklHaYCUYl05x43wtrLTesRwRZ6KR0AvreEkxOwYfV9zj3o7PGxSnrQR1zGHX-qZIO6vFPDAe1Tz8UlZhAKKvBu1uDnL7PrkxqrL24obbv0lwU6ijGiBFG_o9yLKDosIQVffsHepPmHOskForJuiH6m9rrwakQfaolmsVUbQXCHaWId5U6-wtVl3VjMCk6H-r7IwFaBSanUrLz9-NAUC0pUmuKVE2RWlKkljm-eTjHe8VdbCqAV6DUr7h3-UFH_3T9BZxDz5g</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1625816214</pqid></control><display><type>article</type><title>Secular Trends in the Incidence of Cholangiocarcinoma in the USA and the Impact of Misclassification</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Tyson, Gia L. ; Ilyas, Jawad A. ; Duan, Zhigang ; Green, Linda K. ; Younes, Mamoun ; El-Serag, Hashem B. ; Davila, Jessica A.</creator><creatorcontrib>Tyson, Gia L. ; Ilyas, Jawad A. ; Duan, Zhigang ; Green, Linda K. ; Younes, Mamoun ; El-Serag, Hashem B. ; Davila, Jessica A.</creatorcontrib><description>Background and Aims
It has been reported that the incidence of intrahepatic cholangiocarcinoma (ICC) has increased in the USA, while extrahepatic cholangiocarcinoma (ECC) has decreased or remained stable. However, neither the recent trends nor the effects of the misclassification of Klatskin tumors are known.
Methods
Using the Surveillance, Epidemiology, and End Results program databases, we calculated the average annual age-adjusted incidence rates (AA-IRs) of ICC and ECC in 4-year time periods (1992–1995, 1996–1999, 2000–2003, 2004–2007). These AA-IRs were calculated with misclassified as well as correctly classified Klatskin tumors. AA-IRs were also calculated based on age, sex, and race. Multivariable Poisson regression models were used to evaluate the secular trends of ICC and ECC.
Results
The AA-IR of ICC was 0.92 in 1992–1995 and 0.93 in 2004–2007, while the AA-IR of ECC increased from 0.70 in 1992–1995 to 0.95 in 2004–2007. There was no significant trend in AA-IR of ICC (
p
= 0.07), while there was a significant increase in ECC across the 4-year time periods (
p
< 0.001). Klatskin tumors comprised 6.7 % of CCs with approximately 90 and 45 % misclassified as ICC during 1992–2000 and 2001–2007, respectively. Adjusted Poisson models showed no significant differences in the temporal trend of ICC or ECC due to misclassification of Klatskin tumors.
Conclusions
The incidence of ICC has remained stable between 1992 and 2007 with only slight fluctuations, while the incidence of ECC has been increasing. Misclassification of Klatskin tumors does not appear to play a significant role in the trends of CCs.</description><identifier>ISSN: 0163-2116</identifier><identifier>EISSN: 1573-2568</identifier><identifier>DOI: 10.1007/s10620-014-3276-2</identifier><identifier>PMID: 25204668</identifier><identifier>CODEN: DDSCDJ</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Aged ; Analysis ; Bile Duct Neoplasms - classification ; Bile Duct Neoplasms - epidemiology ; Bile Ducts, Intrahepatic - pathology ; Biochemistry ; Cholangiocarcinoma - epidemiology ; Continental Population Groups ; Epidemiology ; Female ; Gastroenterology ; Hepatology ; Humans ; Incidence ; Klatskin Tumor - classification ; Klatskin Tumor - epidemiology ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Oncology ; Original Article ; Pneumoviridae ; Registries ; Time Factors ; Transplant Surgery ; United States - epidemiology</subject><ispartof>Digestive diseases and sciences, 2014-12, Vol.59 (12), p.3103-3110</ispartof><rights>Springer Science+Business Media New York (Outside the USA) 2014</rights><rights>COPYRIGHT 2014 Springer</rights><rights>Springer Science+Business Media New York 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c636t-cda988b1636972760a87f1044492575485a63ffb7ddd6c5b131d0e88e70fbd323</citedby><cites>FETCH-LOGICAL-c636t-cda988b1636972760a87f1044492575485a63ffb7ddd6c5b131d0e88e70fbd323</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10620-014-3276-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10620-014-3276-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25204668$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tyson, Gia L.</creatorcontrib><creatorcontrib>Ilyas, Jawad A.</creatorcontrib><creatorcontrib>Duan, Zhigang</creatorcontrib><creatorcontrib>Green, Linda K.</creatorcontrib><creatorcontrib>Younes, Mamoun</creatorcontrib><creatorcontrib>El-Serag, Hashem B.</creatorcontrib><creatorcontrib>Davila, Jessica A.</creatorcontrib><title>Secular Trends in the Incidence of Cholangiocarcinoma in the USA and the Impact of Misclassification</title><title>Digestive diseases and sciences</title><addtitle>Dig Dis Sci</addtitle><addtitle>Dig Dis Sci</addtitle><description>Background and Aims
It has been reported that the incidence of intrahepatic cholangiocarcinoma (ICC) has increased in the USA, while extrahepatic cholangiocarcinoma (ECC) has decreased or remained stable. However, neither the recent trends nor the effects of the misclassification of Klatskin tumors are known.
Methods
Using the Surveillance, Epidemiology, and End Results program databases, we calculated the average annual age-adjusted incidence rates (AA-IRs) of ICC and ECC in 4-year time periods (1992–1995, 1996–1999, 2000–2003, 2004–2007). These AA-IRs were calculated with misclassified as well as correctly classified Klatskin tumors. AA-IRs were also calculated based on age, sex, and race. Multivariable Poisson regression models were used to evaluate the secular trends of ICC and ECC.
Results
The AA-IR of ICC was 0.92 in 1992–1995 and 0.93 in 2004–2007, while the AA-IR of ECC increased from 0.70 in 1992–1995 to 0.95 in 2004–2007. There was no significant trend in AA-IR of ICC (
p
= 0.07), while there was a significant increase in ECC across the 4-year time periods (
p
< 0.001). Klatskin tumors comprised 6.7 % of CCs with approximately 90 and 45 % misclassified as ICC during 1992–2000 and 2001–2007, respectively. Adjusted Poisson models showed no significant differences in the temporal trend of ICC or ECC due to misclassification of Klatskin tumors.
Conclusions
The incidence of ICC has remained stable between 1992 and 2007 with only slight fluctuations, while the incidence of ECC has been increasing. Misclassification of Klatskin tumors does not appear to play a significant role in the trends of CCs.</description><subject>Aged</subject><subject>Analysis</subject><subject>Bile Duct Neoplasms - classification</subject><subject>Bile Duct Neoplasms - epidemiology</subject><subject>Bile Ducts, Intrahepatic - pathology</subject><subject>Biochemistry</subject><subject>Cholangiocarcinoma - epidemiology</subject><subject>Continental Population Groups</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Gastroenterology</subject><subject>Hepatology</subject><subject>Humans</subject><subject>Incidence</subject><subject>Klatskin Tumor - classification</subject><subject>Klatskin Tumor - epidemiology</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Pneumoviridae</subject><subject>Registries</subject><subject>Time Factors</subject><subject>Transplant Surgery</subject><subject>United States - epidemiology</subject><issn>0163-2116</issn><issn>1573-2568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkltrFTEUhYMo9lj9Ab7IgC--TM09mRfhcPBSqPjQ9jlkcjknZSY5JjOC_94M09ZWFAkkIfnWYu_NAuA1gmcIQvG-IMgxbCGiLcGCt_gJ2CAmSIsZl0_BBiJe7wjxE_CilBsIYScQfw5OMMOQci43wF46Mw86N1fZRVuaEJvp4JrzaIJ10bgm-WZ3SIOO-5CMzibENOo77Ppy2-hoV8l41GZa-K-hmEGXEnwwegopvgTPvB6Ke3V7noLrTx-vdl_ai2-fz3fbi9ZwwqfWWN1J2deieSdqP1BL4RGklHaYCUYl05x43wtrLTesRwRZ6KR0AvreEkxOwYfV9zj3o7PGxSnrQR1zGHX-qZIO6vFPDAe1Tz8UlZhAKKvBu1uDnL7PrkxqrL24obbv0lwU6ijGiBFG_o9yLKDosIQVffsHepPmHOskForJuiH6m9rrwakQfaolmsVUbQXCHaWId5U6-wtVl3VjMCk6H-r7IwFaBSanUrLz9-NAUC0pUmuKVE2RWlKkljm-eTjHe8VdbCqAV6DUr7h3-UFH_3T9BZxDz5g</recordid><startdate>20141201</startdate><enddate>20141201</enddate><creator>Tyson, Gia L.</creator><creator>Ilyas, Jawad A.</creator><creator>Duan, Zhigang</creator><creator>Green, Linda K.</creator><creator>Younes, Mamoun</creator><creator>El-Serag, Hashem B.</creator><creator>Davila, Jessica A.</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>20141201</creationdate><title>Secular Trends in the Incidence of Cholangiocarcinoma in the USA and the Impact of Misclassification</title><author>Tyson, Gia L. ; Ilyas, Jawad A. ; Duan, Zhigang ; Green, Linda K. ; Younes, Mamoun ; El-Serag, Hashem B. ; Davila, Jessica A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c636t-cda988b1636972760a87f1044492575485a63ffb7ddd6c5b131d0e88e70fbd323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aged</topic><topic>Analysis</topic><topic>Bile Duct Neoplasms - classification</topic><topic>Bile Duct Neoplasms - epidemiology</topic><topic>Bile Ducts, Intrahepatic - pathology</topic><topic>Biochemistry</topic><topic>Cholangiocarcinoma - epidemiology</topic><topic>Continental Population Groups</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Gastroenterology</topic><topic>Hepatology</topic><topic>Humans</topic><topic>Incidence</topic><topic>Klatskin Tumor - classification</topic><topic>Klatskin Tumor - epidemiology</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Pneumoviridae</topic><topic>Registries</topic><topic>Time Factors</topic><topic>Transplant Surgery</topic><topic>United States - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tyson, Gia L.</creatorcontrib><creatorcontrib>Ilyas, Jawad A.</creatorcontrib><creatorcontrib>Duan, Zhigang</creatorcontrib><creatorcontrib>Green, Linda K.</creatorcontrib><creatorcontrib>Younes, Mamoun</creatorcontrib><creatorcontrib>El-Serag, Hashem B.</creatorcontrib><creatorcontrib>Davila, Jessica A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Digestive diseases and sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tyson, Gia L.</au><au>Ilyas, Jawad A.</au><au>Duan, Zhigang</au><au>Green, Linda K.</au><au>Younes, Mamoun</au><au>El-Serag, Hashem B.</au><au>Davila, Jessica A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Secular Trends in the Incidence of Cholangiocarcinoma in the USA and the Impact of Misclassification</atitle><jtitle>Digestive diseases and sciences</jtitle><stitle>Dig Dis Sci</stitle><addtitle>Dig Dis Sci</addtitle><date>2014-12-01</date><risdate>2014</risdate><volume>59</volume><issue>12</issue><spage>3103</spage><epage>3110</epage><pages>3103-3110</pages><issn>0163-2116</issn><eissn>1573-2568</eissn><coden>DDSCDJ</coden><abstract>Background and Aims
It has been reported that the incidence of intrahepatic cholangiocarcinoma (ICC) has increased in the USA, while extrahepatic cholangiocarcinoma (ECC) has decreased or remained stable. However, neither the recent trends nor the effects of the misclassification of Klatskin tumors are known.
Methods
Using the Surveillance, Epidemiology, and End Results program databases, we calculated the average annual age-adjusted incidence rates (AA-IRs) of ICC and ECC in 4-year time periods (1992–1995, 1996–1999, 2000–2003, 2004–2007). These AA-IRs were calculated with misclassified as well as correctly classified Klatskin tumors. AA-IRs were also calculated based on age, sex, and race. Multivariable Poisson regression models were used to evaluate the secular trends of ICC and ECC.
Results
The AA-IR of ICC was 0.92 in 1992–1995 and 0.93 in 2004–2007, while the AA-IR of ECC increased from 0.70 in 1992–1995 to 0.95 in 2004–2007. There was no significant trend in AA-IR of ICC (
p
= 0.07), while there was a significant increase in ECC across the 4-year time periods (
p
< 0.001). Klatskin tumors comprised 6.7 % of CCs with approximately 90 and 45 % misclassified as ICC during 1992–2000 and 2001–2007, respectively. Adjusted Poisson models showed no significant differences in the temporal trend of ICC or ECC due to misclassification of Klatskin tumors.
Conclusions
The incidence of ICC has remained stable between 1992 and 2007 with only slight fluctuations, while the incidence of ECC has been increasing. Misclassification of Klatskin tumors does not appear to play a significant role in the trends of CCs.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>25204668</pmid><doi>10.1007/s10620-014-3276-2</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Digestive diseases and sciences, 2014-12, Vol.59 (12), p.3103-3110 |
| issn | 0163-2116 1573-2568 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Aged Analysis Bile Duct Neoplasms - classification Bile Duct Neoplasms - epidemiology Bile Ducts, Intrahepatic - pathology Biochemistry Cholangiocarcinoma - epidemiology Continental Population Groups Epidemiology Female Gastroenterology Hepatology Humans Incidence Klatskin Tumor - classification Klatskin Tumor - epidemiology Male Medicine Medicine & Public Health Middle Aged Oncology Original Article Pneumoviridae Registries Time Factors Transplant Surgery United States - epidemiology |
| title | Secular Trends in the Incidence of Cholangiocarcinoma in the USA and the Impact of Misclassification |
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