New strategies against drug resistance to herpes simplex virus

Herpes simplex virus (HSV), a member of the Herpesviridae family, is a significant human pathogen that results in mucocutaneous lesions in the oral cavity or genital infections. Acyclovir (ACV) and related nucleoside analogues can successfully treat HSV infections, but the emergence of drug resistan...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:International journal of oral science 2016-03, Vol.8 (1), p.1-6
Hauptverfasser: Jiang, Yu-Chen, Feng, Hui, Lin, Yu-Chun, Guo, Xiu-Rong
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 6
container_issue 1
container_start_page 1
container_title International journal of oral science
container_volume 8
creator Jiang, Yu-Chen
Feng, Hui
Lin, Yu-Chun
Guo, Xiu-Rong
description Herpes simplex virus (HSV), a member of the Herpesviridae family, is a significant human pathogen that results in mucocutaneous lesions in the oral cavity or genital infections. Acyclovir (ACV) and related nucleoside analogues can successfully treat HSV infections, but the emergence of drug resistance to ACV has created a barrier for the treatment of HSV infections, especially in immunocompromised patients. There is an urgent need to explore new and effective tactics to circumvent drug resistance to HSV. This review summarises the current strategies in the development of new targets (the DNA helicase/primase (H/P) complex), new types of molecules (nature products) and new antiviral mechanisms (lethal mutagenesis of Janus-type nucleosides) to fight the drug resistance of HSV.
doi_str_mv 10.1038/ijos.2016.3
format Article
fullrecord <record><control><sourceid>wanfang_jour_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4822185</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><cqvip_id>668656637</cqvip_id><wanfj_id>gjkqkxzz_e201601001</wanfj_id><sourcerecordid>gjkqkxzz_e201601001</sourcerecordid><originalsourceid>FETCH-LOGICAL-c509t-7707cfa478faf29cb8ec3684d811ddef9228de2ee4aa6298096d7612d817ab393</originalsourceid><addsrcrecordid>eNptkclOwzAURS0EgjKs2KMIlpDiIfGwqYQQk4RgA2vLTV5Sl9Zp7YTp63HVUkBi5cU7PvfaD6FDgvsEM3lux03oU0x4n22gHsWZShnhahP1CBdZSiWRO2g3hDHGXOaUbKMdKjDNaa56aPAAb0lovWmhthASUxvrQpuUvqsTD8GG1rgCkrZJRuBnkQh2OpvAe_JqfRf20VZlJgEOVuceer6-erq8Te8fb-4uL-7TIseqTYXAoqhMJmRlKqqKoYSCcZmVkpCyhEpRKkugAJkxnCqJFS8FJzTOhRkyxfbQYOmddcMplAW4WHmiZ95Ojf_QjbH678TZka6bV51JSonMo-B0KXgzrjKu1uOm8y5W1vX4Zf7y_vmpYfGHmGBMIn2yivPNvIPQ_uBEKBV9IhM_zsI3IXio1n0I1ovV6MVq9EKrWaSPfj9hzX7vIgJnSyDEkavB_wr913e8Sh81rp7HG2sl55LnnDPBvgA8MKW8</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1799853747</pqid></control><display><type>article</type><title>New strategies against drug resistance to herpes simplex virus</title><source>MEDLINE</source><source>Nature Free</source><source>DOAJ Directory of Open Access Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>PubMed Central Open Access</source><source>Springer Nature OA Free Journals</source><creator>Jiang, Yu-Chen ; Feng, Hui ; Lin, Yu-Chun ; Guo, Xiu-Rong</creator><creatorcontrib>Jiang, Yu-Chen ; Feng, Hui ; Lin, Yu-Chun ; Guo, Xiu-Rong</creatorcontrib><description>Herpes simplex virus (HSV), a member of the Herpesviridae family, is a significant human pathogen that results in mucocutaneous lesions in the oral cavity or genital infections. Acyclovir (ACV) and related nucleoside analogues can successfully treat HSV infections, but the emergence of drug resistance to ACV has created a barrier for the treatment of HSV infections, especially in immunocompromised patients. There is an urgent need to explore new and effective tactics to circumvent drug resistance to HSV. This review summarises the current strategies in the development of new targets (the DNA helicase/primase (H/P) complex), new types of molecules (nature products) and new antiviral mechanisms (lethal mutagenesis of Janus-type nucleosides) to fight the drug resistance of HSV.</description><identifier>ISSN: 1674-2818</identifier><identifier>EISSN: 2049-3169</identifier><identifier>DOI: 10.1038/ijos.2016.3</identifier><identifier>PMID: 27025259</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Acyclovir - pharmacology ; Antiviral Agents - chemistry ; Antiviral Agents - pharmacology ; Dentistry ; DNA解旋酶 ; Drug Resistance ; Herpes Labialis - drug therapy ; HSV ; Humans ; Immunocompromised Host ; Medicine ; Molecular Structure ; Mutagenesis - drug effects ; Nucleosides - chemistry ; Nucleosides - pharmacology ; Oral and Maxillofacial Surgery ; Orthopedics ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; Review ; Simplexvirus - drug effects ; Stomatitis, Herpetic - drug therapy ; Surgical Orthopedics ; 免疫功能低下 ; 单纯疱疹病毒 ; 核苷类似物 ; 耐药性 ; 药物 ; 阿昔洛韦</subject><ispartof>International journal of oral science, 2016-03, Vol.8 (1), p.1-6</ispartof><rights>The Author(s) 2016</rights><rights>Copyright Nature Publishing Group Mar 2016</rights><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><rights>Copyright © 2016 Macmillan Publishers Limited 2016 Macmillan Publishers Limited</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c509t-7707cfa478faf29cb8ec3684d811ddef9228de2ee4aa6298096d7612d817ab393</citedby><cites>FETCH-LOGICAL-c509t-7707cfa478faf29cb8ec3684d811ddef9228de2ee4aa6298096d7612d817ab393</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/89520X/89520X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822185/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822185/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,41096,42165,51551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27025259$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jiang, Yu-Chen</creatorcontrib><creatorcontrib>Feng, Hui</creatorcontrib><creatorcontrib>Lin, Yu-Chun</creatorcontrib><creatorcontrib>Guo, Xiu-Rong</creatorcontrib><title>New strategies against drug resistance to herpes simplex virus</title><title>International journal of oral science</title><addtitle>Int J Oral Sci</addtitle><addtitle>International Journal of Oral Science</addtitle><description>Herpes simplex virus (HSV), a member of the Herpesviridae family, is a significant human pathogen that results in mucocutaneous lesions in the oral cavity or genital infections. Acyclovir (ACV) and related nucleoside analogues can successfully treat HSV infections, but the emergence of drug resistance to ACV has created a barrier for the treatment of HSV infections, especially in immunocompromised patients. There is an urgent need to explore new and effective tactics to circumvent drug resistance to HSV. This review summarises the current strategies in the development of new targets (the DNA helicase/primase (H/P) complex), new types of molecules (nature products) and new antiviral mechanisms (lethal mutagenesis of Janus-type nucleosides) to fight the drug resistance of HSV.</description><subject>Acyclovir - pharmacology</subject><subject>Antiviral Agents - chemistry</subject><subject>Antiviral Agents - pharmacology</subject><subject>Dentistry</subject><subject>DNA解旋酶</subject><subject>Drug Resistance</subject><subject>Herpes Labialis - drug therapy</subject><subject>HSV</subject><subject>Humans</subject><subject>Immunocompromised Host</subject><subject>Medicine</subject><subject>Molecular Structure</subject><subject>Mutagenesis - drug effects</subject><subject>Nucleosides - chemistry</subject><subject>Nucleosides - pharmacology</subject><subject>Oral and Maxillofacial Surgery</subject><subject>Orthopedics</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>Review</subject><subject>Simplexvirus - drug effects</subject><subject>Stomatitis, Herpetic - drug therapy</subject><subject>Surgical Orthopedics</subject><subject>免疫功能低下</subject><subject>单纯疱疹病毒</subject><subject>核苷类似物</subject><subject>耐药性</subject><subject>药物</subject><subject>阿昔洛韦</subject><issn>1674-2818</issn><issn>2049-3169</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNptkclOwzAURS0EgjKs2KMIlpDiIfGwqYQQk4RgA2vLTV5Sl9Zp7YTp63HVUkBi5cU7PvfaD6FDgvsEM3lux03oU0x4n22gHsWZShnhahP1CBdZSiWRO2g3hDHGXOaUbKMdKjDNaa56aPAAb0lovWmhthASUxvrQpuUvqsTD8GG1rgCkrZJRuBnkQh2OpvAe_JqfRf20VZlJgEOVuceer6-erq8Te8fb-4uL-7TIseqTYXAoqhMJmRlKqqKoYSCcZmVkpCyhEpRKkugAJkxnCqJFS8FJzTOhRkyxfbQYOmddcMplAW4WHmiZ95Ojf_QjbH678TZka6bV51JSonMo-B0KXgzrjKu1uOm8y5W1vX4Zf7y_vmpYfGHmGBMIn2yivPNvIPQ_uBEKBV9IhM_zsI3IXio1n0I1ovV6MVq9EKrWaSPfj9hzX7vIgJnSyDEkavB_wr913e8Sh81rp7HG2sl55LnnDPBvgA8MKW8</recordid><startdate>20160330</startdate><enddate>20160330</enddate><creator>Jiang, Yu-Chen</creator><creator>Feng, Hui</creator><creator>Lin, Yu-Chun</creator><creator>Guo, Xiu-Rong</creator><general>Nature Publishing Group UK</general><general>Springer Nature B.V</general><general>State Key Laboratory of 0ral Disease, West China School of Stomatology, Sichuan University, Chengdu, China%XiangYa Stomatological Hospital, Central South University, Changsha, China%Center for Nanotechnology, Munster, Germany, West China Medical School, Sichuan University, Chengdu, China</general><general>Nature Publishing Group</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope><scope>5PM</scope></search><sort><creationdate>20160330</creationdate><title>New strategies against drug resistance to herpes simplex virus</title><author>Jiang, Yu-Chen ; Feng, Hui ; Lin, Yu-Chun ; Guo, Xiu-Rong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c509t-7707cfa478faf29cb8ec3684d811ddef9228de2ee4aa6298096d7612d817ab393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Acyclovir - pharmacology</topic><topic>Antiviral Agents - chemistry</topic><topic>Antiviral Agents - pharmacology</topic><topic>Dentistry</topic><topic>DNA解旋酶</topic><topic>Drug Resistance</topic><topic>Herpes Labialis - drug therapy</topic><topic>HSV</topic><topic>Humans</topic><topic>Immunocompromised Host</topic><topic>Medicine</topic><topic>Molecular Structure</topic><topic>Mutagenesis - drug effects</topic><topic>Nucleosides - chemistry</topic><topic>Nucleosides - pharmacology</topic><topic>Oral and Maxillofacial Surgery</topic><topic>Orthopedics</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - pharmacology</topic><topic>Review</topic><topic>Simplexvirus - drug effects</topic><topic>Stomatitis, Herpetic - drug therapy</topic><topic>Surgical Orthopedics</topic><topic>免疫功能低下</topic><topic>单纯疱疹病毒</topic><topic>核苷类似物</topic><topic>耐药性</topic><topic>药物</topic><topic>阿昔洛韦</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jiang, Yu-Chen</creatorcontrib><creatorcontrib>Feng, Hui</creatorcontrib><creatorcontrib>Lin, Yu-Chun</creatorcontrib><creatorcontrib>Guo, Xiu-Rong</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of oral science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jiang, Yu-Chen</au><au>Feng, Hui</au><au>Lin, Yu-Chun</au><au>Guo, Xiu-Rong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>New strategies against drug resistance to herpes simplex virus</atitle><jtitle>International journal of oral science</jtitle><stitle>Int J Oral Sci</stitle><addtitle>International Journal of Oral Science</addtitle><date>2016-03-30</date><risdate>2016</risdate><volume>8</volume><issue>1</issue><spage>1</spage><epage>6</epage><pages>1-6</pages><issn>1674-2818</issn><eissn>2049-3169</eissn><abstract>Herpes simplex virus (HSV), a member of the Herpesviridae family, is a significant human pathogen that results in mucocutaneous lesions in the oral cavity or genital infections. Acyclovir (ACV) and related nucleoside analogues can successfully treat HSV infections, but the emergence of drug resistance to ACV has created a barrier for the treatment of HSV infections, especially in immunocompromised patients. There is an urgent need to explore new and effective tactics to circumvent drug resistance to HSV. This review summarises the current strategies in the development of new targets (the DNA helicase/primase (H/P) complex), new types of molecules (nature products) and new antiviral mechanisms (lethal mutagenesis of Janus-type nucleosides) to fight the drug resistance of HSV.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>27025259</pmid><doi>10.1038/ijos.2016.3</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1674-2818
ispartof International journal of oral science, 2016-03, Vol.8 (1), p.1-6
issn 1674-2818
2049-3169
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4822185
source MEDLINE; Nature Free; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; PubMed Central Open Access; Springer Nature OA Free Journals
subjects Acyclovir - pharmacology
Antiviral Agents - chemistry
Antiviral Agents - pharmacology
Dentistry
DNA解旋酶
Drug Resistance
Herpes Labialis - drug therapy
HSV
Humans
Immunocompromised Host
Medicine
Molecular Structure
Mutagenesis - drug effects
Nucleosides - chemistry
Nucleosides - pharmacology
Oral and Maxillofacial Surgery
Orthopedics
Plant Extracts - chemistry
Plant Extracts - pharmacology
Review
Simplexvirus - drug effects
Stomatitis, Herpetic - drug therapy
Surgical Orthopedics
免疫功能低下
单纯疱疹病毒
核苷类似物
耐药性
药物
阿昔洛韦
title New strategies against drug resistance to herpes simplex virus
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T10%3A05%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-wanfang_jour_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=New%20strategies%20against%20drug%20resistance%20to%20herpes%20simplex%20virus&rft.jtitle=International%20journal%20of%20oral%20science&rft.au=Jiang,%20Yu-Chen&rft.date=2016-03-30&rft.volume=8&rft.issue=1&rft.spage=1&rft.epage=6&rft.pages=1-6&rft.issn=1674-2818&rft.eissn=2049-3169&rft_id=info:doi/10.1038/ijos.2016.3&rft_dat=%3Cwanfang_jour_pubme%3Egjkqkxzz_e201601001%3C/wanfang_jour_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1799853747&rft_id=info:pmid/27025259&rft_cqvip_id=668656637&rft_wanfj_id=gjkqkxzz_e201601001&rfr_iscdi=true