New strategies against drug resistance to herpes simplex virus
Herpes simplex virus (HSV), a member of the Herpesviridae family, is a significant human pathogen that results in mucocutaneous lesions in the oral cavity or genital infections. Acyclovir (ACV) and related nucleoside analogues can successfully treat HSV infections, but the emergence of drug resistan...
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description | Herpes simplex virus (HSV), a member of the Herpesviridae family, is a significant human pathogen that results in mucocutaneous lesions in the oral cavity or genital infections. Acyclovir (ACV) and related nucleoside analogues can successfully treat HSV infections, but the emergence of drug resistance to ACV has created a barrier for the treatment of HSV infections, especially in immunocompromised patients. There is an urgent need to explore new and effective tactics to circumvent drug resistance to HSV. This review summarises the current strategies in the development of new targets (the DNA helicase/primase (H/P) complex), new types of molecules (nature products) and new antiviral mechanisms (lethal mutagenesis of Janus-type nucleosides) to fight the drug resistance of HSV. |
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Acyclovir (ACV) and related nucleoside analogues can successfully treat HSV infections, but the emergence of drug resistance to ACV has created a barrier for the treatment of HSV infections, especially in immunocompromised patients. There is an urgent need to explore new and effective tactics to circumvent drug resistance to HSV. This review summarises the current strategies in the development of new targets (the DNA helicase/primase (H/P) complex), new types of molecules (nature products) and new antiviral mechanisms (lethal mutagenesis of Janus-type nucleosides) to fight the drug resistance of HSV.</description><identifier>ISSN: 1674-2818</identifier><identifier>EISSN: 2049-3169</identifier><identifier>DOI: 10.1038/ijos.2016.3</identifier><identifier>PMID: 27025259</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Acyclovir - pharmacology ; Antiviral Agents - chemistry ; Antiviral Agents - pharmacology ; Dentistry ; DNA解旋酶 ; Drug Resistance ; Herpes Labialis - drug therapy ; HSV ; Humans ; Immunocompromised Host ; Medicine ; Molecular Structure ; Mutagenesis - drug effects ; Nucleosides - chemistry ; Nucleosides - pharmacology ; Oral and Maxillofacial Surgery ; Orthopedics ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; Review ; Simplexvirus - drug effects ; Stomatitis, Herpetic - drug therapy ; Surgical Orthopedics ; 免疫功能低下 ; 单纯疱疹病毒 ; 核苷类似物 ; 耐药性 ; 药物 ; 阿昔洛韦</subject><ispartof>International journal of oral science, 2016-03, Vol.8 (1), p.1-6</ispartof><rights>The Author(s) 2016</rights><rights>Copyright Nature Publishing Group Mar 2016</rights><rights>Copyright © Wanfang Data Co. 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All Rights Reserved.</rights><rights>Copyright © 2016 Macmillan Publishers Limited 2016 Macmillan Publishers Limited</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c509t-7707cfa478faf29cb8ec3684d811ddef9228de2ee4aa6298096d7612d817ab393</citedby><cites>FETCH-LOGICAL-c509t-7707cfa478faf29cb8ec3684d811ddef9228de2ee4aa6298096d7612d817ab393</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/89520X/89520X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822185/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822185/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,41096,42165,51551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27025259$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jiang, Yu-Chen</creatorcontrib><creatorcontrib>Feng, Hui</creatorcontrib><creatorcontrib>Lin, Yu-Chun</creatorcontrib><creatorcontrib>Guo, Xiu-Rong</creatorcontrib><title>New strategies against drug resistance to herpes simplex virus</title><title>International journal of oral science</title><addtitle>Int J Oral Sci</addtitle><addtitle>International Journal of Oral Science</addtitle><description>Herpes simplex virus (HSV), a member of the Herpesviridae family, is a significant human pathogen that results in mucocutaneous lesions in the oral cavity or genital infections. Acyclovir (ACV) and related nucleoside analogues can successfully treat HSV infections, but the emergence of drug resistance to ACV has created a barrier for the treatment of HSV infections, especially in immunocompromised patients. There is an urgent need to explore new and effective tactics to circumvent drug resistance to HSV. This review summarises the current strategies in the development of new targets (the DNA helicase/primase (H/P) complex), new types of molecules (nature products) and new antiviral mechanisms (lethal mutagenesis of Janus-type nucleosides) to fight the drug resistance of HSV.</description><subject>Acyclovir - pharmacology</subject><subject>Antiviral Agents - chemistry</subject><subject>Antiviral Agents - pharmacology</subject><subject>Dentistry</subject><subject>DNA解旋酶</subject><subject>Drug Resistance</subject><subject>Herpes Labialis - drug therapy</subject><subject>HSV</subject><subject>Humans</subject><subject>Immunocompromised Host</subject><subject>Medicine</subject><subject>Molecular Structure</subject><subject>Mutagenesis - drug effects</subject><subject>Nucleosides - chemistry</subject><subject>Nucleosides - pharmacology</subject><subject>Oral and Maxillofacial Surgery</subject><subject>Orthopedics</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>Review</subject><subject>Simplexvirus - drug effects</subject><subject>Stomatitis, Herpetic - drug therapy</subject><subject>Surgical Orthopedics</subject><subject>免疫功能低下</subject><subject>单纯疱疹病毒</subject><subject>核苷类似物</subject><subject>耐药性</subject><subject>药物</subject><subject>阿昔洛韦</subject><issn>1674-2818</issn><issn>2049-3169</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNptkclOwzAURS0EgjKs2KMIlpDiIfGwqYQQk4RgA2vLTV5Sl9Zp7YTp63HVUkBi5cU7PvfaD6FDgvsEM3lux03oU0x4n22gHsWZShnhahP1CBdZSiWRO2g3hDHGXOaUbKMdKjDNaa56aPAAb0lovWmhthASUxvrQpuUvqsTD8GG1rgCkrZJRuBnkQh2OpvAe_JqfRf20VZlJgEOVuceer6-erq8Te8fb-4uL-7TIseqTYXAoqhMJmRlKqqKoYSCcZmVkpCyhEpRKkugAJkxnCqJFS8FJzTOhRkyxfbQYOmddcMplAW4WHmiZ95Ojf_QjbH678TZka6bV51JSonMo-B0KXgzrjKu1uOm8y5W1vX4Zf7y_vmpYfGHmGBMIn2yivPNvIPQ_uBEKBV9IhM_zsI3IXio1n0I1ovV6MVq9EKrWaSPfj9hzX7vIgJnSyDEkavB_wr913e8Sh81rp7HG2sl55LnnDPBvgA8MKW8</recordid><startdate>20160330</startdate><enddate>20160330</enddate><creator>Jiang, Yu-Chen</creator><creator>Feng, Hui</creator><creator>Lin, Yu-Chun</creator><creator>Guo, Xiu-Rong</creator><general>Nature Publishing Group UK</general><general>Springer Nature B.V</general><general>State Key Laboratory of 0ral Disease, West China School of Stomatology, Sichuan University, Chengdu, China%XiangYa Stomatological Hospital, Central South University, Changsha, China%Center for Nanotechnology, Munster, Germany, West China Medical School, Sichuan University, Chengdu, China</general><general>Nature Publishing Group</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope><scope>5PM</scope></search><sort><creationdate>20160330</creationdate><title>New strategies against drug resistance to herpes simplex virus</title><author>Jiang, Yu-Chen ; 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Acyclovir (ACV) and related nucleoside analogues can successfully treat HSV infections, but the emergence of drug resistance to ACV has created a barrier for the treatment of HSV infections, especially in immunocompromised patients. There is an urgent need to explore new and effective tactics to circumvent drug resistance to HSV. This review summarises the current strategies in the development of new targets (the DNA helicase/primase (H/P) complex), new types of molecules (nature products) and new antiviral mechanisms (lethal mutagenesis of Janus-type nucleosides) to fight the drug resistance of HSV.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>27025259</pmid><doi>10.1038/ijos.2016.3</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Acyclovir - pharmacology Antiviral Agents - chemistry Antiviral Agents - pharmacology Dentistry DNA解旋酶 Drug Resistance Herpes Labialis - drug therapy HSV Humans Immunocompromised Host Medicine Molecular Structure Mutagenesis - drug effects Nucleosides - chemistry Nucleosides - pharmacology Oral and Maxillofacial Surgery Orthopedics Plant Extracts - chemistry Plant Extracts - pharmacology Review Simplexvirus - drug effects Stomatitis, Herpetic - drug therapy Surgical Orthopedics 免疫功能低下 单纯疱疹病毒 核苷类似物 耐药性 药物 阿昔洛韦 |
title | New strategies against drug resistance to herpes simplex virus |
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