Reverse vaccinology 2.0: Human immunology instructs vaccine antigen design

Traditionally, vaccines have been developed by cultivating infectious agents and isolating the inactivated whole pathogen or some of its purified components. 20 years ago, reverse vaccinology enabled vaccine discovery and design based on information deriving from the sequence of microbial genomes ra...

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Veröffentlicht in:	The Journal of experimental medicine 2016-04, Vol.213 (4), p.469-481
Hauptverfasser:	Rappuoli, Rino, Bottomley, Matthew J, D'Oro, Ugo, Finco, Oretta, De Gregorio, Ennio
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens - genetics Antigens - immunology Drug Design Epitopes - genetics Epitopes - immunology Humans Reviews Vaccines - genetics Vaccines - immunology
Online-Zugang:	Volltext
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