Early auditory processing evoked potentials (N100) show a continuum of blunting from clinical high risk to psychosis in a pediatric sample
AbstractBackgroundThe N100 is a negative deflection in the surface EEG approximately 100 ms after an auditory signal. It has been shown to be reduced in individuals with schizophrenia and those at clinical high risk (CHR). N100 blunting may index neural network dysfunction underlying psychotic sympt...
Gespeichert in:
| Veröffentlicht in: | Schizophrenia research 2015-12, Vol.169 (1), p.340-345 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 345 |
|---|---|
| container_issue | 1 |
| container_start_page | 340 |
| container_title | Schizophrenia research |
| container_volume | 169 |
| creator | Gonzalez-Heydrich, Joseph Bosquet Enlow, Michelle D'Angelo, Eugene Seidman, Larry J Gumlak, Sarah Kim, April Woodberry, Kristen A Rober, Ashley Tembulkar, Sahil Graber, Kelsey O'Donnell, Kyle Hamoda, Hesham M Kimball, Kara Rotenberg, Alexander Oberman, Lindsay M Pascual-Leone, Alvaro Keshavan, Matcheri S Duffy, Frank H |
| description | AbstractBackgroundThe N100 is a negative deflection in the surface EEG approximately 100 ms after an auditory signal. It has been shown to be reduced in individuals with schizophrenia and those at clinical high risk (CHR). N100 blunting may index neural network dysfunction underlying psychotic symptoms. This phenomenon has received little attention in pediatric populations. MethodThis cross-sectional study compared the N100 response measured via the average EEG response at the left medial frontal position FC1 to 150 sinusoidal tones in participants ages 5 to 17 years with a CHR syndrome ( n= 29), a psychotic disorder ( n= 22), or healthy controls ( n= 17). ResultsLinear regression analyses that considered potential covariates (age, gender, handedness, family mental health history, medication usage) revealed decreasing N100 amplitude with increasing severity of psychotic symptomatology from healthy to CHR to psychotic level. ConclusionsLongitudinal assessment of the N100 in CHR children who do and do not develop psychosis will inform whether it predicts transition to psychosis and if its response to treatment predicts symptom change. |
| doi_str_mv | 10.1016/j.schres.2015.10.037 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4821005</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0920996415300372</els_id><sourcerecordid>1749992161</sourcerecordid><originalsourceid>FETCH-LOGICAL-c518t-7f15872603c6b49af0e5ce628fd8894b89e7c479a9f44603069a535b4b7dda9c3</originalsourceid><addsrcrecordid>eNqFUs1u1DAQjhCILoU3QMjHcshiO3YSX5BQ1QJSBQfgbDnOZOPdJA6eZKu8Ak9dR9uWnwsny-PvxzPfJMlrRreMsvzdfou2DYBbTpmMpS3NiifJhskiS7mk6mmyoYrTVKlcnCUvEPeURiQtnidnPJdC5Vxtkl9XJnQLMXPtJh8WMgZvAdENOwJHf4CajH6CYXKmQ3LxhVH6lmDrb4kh1sfyMM898Q2punm97UgTfE9s5wZnTUdat2tJcHggkycjLrb16JC4IfJHqJ2ZgrMETT928DJ51kQXeHV_nic_rq--X35Kb75-_Hz54Sa1kpVTWjRMlgXPaWbzSijTUJAWcl42dVkqUZUKCisKZVQjRETRXBmZyUpURV0bZbPz5P1Jd5yrHmobuwum02NwvQmL9sbpv18G1-qdP2pR8ti_jAIX9wLB_5wBJ907tNB1ZgA_o2aFUEpxlrMIFSeoDR4xQPNow6heY9R7fYpRrzGu1RhjpL3584uPpIfcfvcAcVBHByGqOBhsHGkAO-nau_85_CvwkNkBFsC9n8MQQ9BMI9dUf1tXad0kJjMa-Ty7A885yEE</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1749992161</pqid></control><display><type>article</type><title>Early auditory processing evoked potentials (N100) show a continuum of blunting from clinical high risk to psychosis in a pediatric sample</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Gonzalez-Heydrich, Joseph ; Bosquet Enlow, Michelle ; D'Angelo, Eugene ; Seidman, Larry J ; Gumlak, Sarah ; Kim, April ; Woodberry, Kristen A ; Rober, Ashley ; Tembulkar, Sahil ; Graber, Kelsey ; O'Donnell, Kyle ; Hamoda, Hesham M ; Kimball, Kara ; Rotenberg, Alexander ; Oberman, Lindsay M ; Pascual-Leone, Alvaro ; Keshavan, Matcheri S ; Duffy, Frank H</creator><creatorcontrib>Gonzalez-Heydrich, Joseph ; Bosquet Enlow, Michelle ; D'Angelo, Eugene ; Seidman, Larry J ; Gumlak, Sarah ; Kim, April ; Woodberry, Kristen A ; Rober, Ashley ; Tembulkar, Sahil ; Graber, Kelsey ; O'Donnell, Kyle ; Hamoda, Hesham M ; Kimball, Kara ; Rotenberg, Alexander ; Oberman, Lindsay M ; Pascual-Leone, Alvaro ; Keshavan, Matcheri S ; Duffy, Frank H</creatorcontrib><description>AbstractBackgroundThe N100 is a negative deflection in the surface EEG approximately 100 ms after an auditory signal. It has been shown to be reduced in individuals with schizophrenia and those at clinical high risk (CHR). N100 blunting may index neural network dysfunction underlying psychotic symptoms. This phenomenon has received little attention in pediatric populations. MethodThis cross-sectional study compared the N100 response measured via the average EEG response at the left medial frontal position FC1 to 150 sinusoidal tones in participants ages 5 to 17 years with a CHR syndrome ( n= 29), a psychotic disorder ( n= 22), or healthy controls ( n= 17). ResultsLinear regression analyses that considered potential covariates (age, gender, handedness, family mental health history, medication usage) revealed decreasing N100 amplitude with increasing severity of psychotic symptomatology from healthy to CHR to psychotic level. ConclusionsLongitudinal assessment of the N100 in CHR children who do and do not develop psychosis will inform whether it predicts transition to psychosis and if its response to treatment predicts symptom change.</description><identifier>ISSN: 0920-9964</identifier><identifier>EISSN: 1573-2509</identifier><identifier>DOI: 10.1016/j.schres.2015.10.037</identifier><identifier>PMID: 26549629</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Acoustic Stimulation ; Adolescent ; Analysis of Variance ; Child ; Child, Preschool ; Clinical high risk ; Early onset ; Electroencephalography ; Evoked Potentials, Auditory - physiology ; Female ; Humans ; Linear Models ; Male ; N100 ; Psychiatric Status Rating Scales ; Psychiatric/Mental Health ; Psychosis ; Schizophrenia ; Schizophrenia - physiopathology ; Superior temporal cortex</subject><ispartof>Schizophrenia research, 2015-12, Vol.169 (1), p.340-345</ispartof><rights>Elsevier B.V.</rights><rights>2015 Elsevier B.V.</rights><rights>Copyright © 2015 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c518t-7f15872603c6b49af0e5ce628fd8894b89e7c479a9f44603069a535b4b7dda9c3</citedby><cites>FETCH-LOGICAL-c518t-7f15872603c6b49af0e5ce628fd8894b89e7c479a9f44603069a535b4b7dda9c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.schres.2015.10.037$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,778,782,883,3539,27911,27912,45982</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26549629$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gonzalez-Heydrich, Joseph</creatorcontrib><creatorcontrib>Bosquet Enlow, Michelle</creatorcontrib><creatorcontrib>D'Angelo, Eugene</creatorcontrib><creatorcontrib>Seidman, Larry J</creatorcontrib><creatorcontrib>Gumlak, Sarah</creatorcontrib><creatorcontrib>Kim, April</creatorcontrib><creatorcontrib>Woodberry, Kristen A</creatorcontrib><creatorcontrib>Rober, Ashley</creatorcontrib><creatorcontrib>Tembulkar, Sahil</creatorcontrib><creatorcontrib>Graber, Kelsey</creatorcontrib><creatorcontrib>O'Donnell, Kyle</creatorcontrib><creatorcontrib>Hamoda, Hesham M</creatorcontrib><creatorcontrib>Kimball, Kara</creatorcontrib><creatorcontrib>Rotenberg, Alexander</creatorcontrib><creatorcontrib>Oberman, Lindsay M</creatorcontrib><creatorcontrib>Pascual-Leone, Alvaro</creatorcontrib><creatorcontrib>Keshavan, Matcheri S</creatorcontrib><creatorcontrib>Duffy, Frank H</creatorcontrib><title>Early auditory processing evoked potentials (N100) show a continuum of blunting from clinical high risk to psychosis in a pediatric sample</title><title>Schizophrenia research</title><addtitle>Schizophr Res</addtitle><description>AbstractBackgroundThe N100 is a negative deflection in the surface EEG approximately 100 ms after an auditory signal. It has been shown to be reduced in individuals with schizophrenia and those at clinical high risk (CHR). N100 blunting may index neural network dysfunction underlying psychotic symptoms. This phenomenon has received little attention in pediatric populations. MethodThis cross-sectional study compared the N100 response measured via the average EEG response at the left medial frontal position FC1 to 150 sinusoidal tones in participants ages 5 to 17 years with a CHR syndrome ( n= 29), a psychotic disorder ( n= 22), or healthy controls ( n= 17). ResultsLinear regression analyses that considered potential covariates (age, gender, handedness, family mental health history, medication usage) revealed decreasing N100 amplitude with increasing severity of psychotic symptomatology from healthy to CHR to psychotic level. ConclusionsLongitudinal assessment of the N100 in CHR children who do and do not develop psychosis will inform whether it predicts transition to psychosis and if its response to treatment predicts symptom change.</description><subject>Acoustic Stimulation</subject><subject>Adolescent</subject><subject>Analysis of Variance</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Clinical high risk</subject><subject>Early onset</subject><subject>Electroencephalography</subject><subject>Evoked Potentials, Auditory - physiology</subject><subject>Female</subject><subject>Humans</subject><subject>Linear Models</subject><subject>Male</subject><subject>N100</subject><subject>Psychiatric Status Rating Scales</subject><subject>Psychiatric/Mental Health</subject><subject>Psychosis</subject><subject>Schizophrenia</subject><subject>Schizophrenia - physiopathology</subject><subject>Superior temporal cortex</subject><issn>0920-9964</issn><issn>1573-2509</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUs1u1DAQjhCILoU3QMjHcshiO3YSX5BQ1QJSBQfgbDnOZOPdJA6eZKu8Ak9dR9uWnwsny-PvxzPfJMlrRreMsvzdfou2DYBbTpmMpS3NiifJhskiS7mk6mmyoYrTVKlcnCUvEPeURiQtnidnPJdC5Vxtkl9XJnQLMXPtJh8WMgZvAdENOwJHf4CajH6CYXKmQ3LxhVH6lmDrb4kh1sfyMM898Q2punm97UgTfE9s5wZnTUdat2tJcHggkycjLrb16JC4IfJHqJ2ZgrMETT928DJ51kQXeHV_nic_rq--X35Kb75-_Hz54Sa1kpVTWjRMlgXPaWbzSijTUJAWcl42dVkqUZUKCisKZVQjRETRXBmZyUpURV0bZbPz5P1Jd5yrHmobuwum02NwvQmL9sbpv18G1-qdP2pR8ti_jAIX9wLB_5wBJ907tNB1ZgA_o2aFUEpxlrMIFSeoDR4xQPNow6heY9R7fYpRrzGu1RhjpL3584uPpIfcfvcAcVBHByGqOBhsHGkAO-nau_85_CvwkNkBFsC9n8MQQ9BMI9dUf1tXad0kJjMa-Ty7A885yEE</recordid><startdate>20151201</startdate><enddate>20151201</enddate><creator>Gonzalez-Heydrich, Joseph</creator><creator>Bosquet Enlow, Michelle</creator><creator>D'Angelo, Eugene</creator><creator>Seidman, Larry J</creator><creator>Gumlak, Sarah</creator><creator>Kim, April</creator><creator>Woodberry, Kristen A</creator><creator>Rober, Ashley</creator><creator>Tembulkar, Sahil</creator><creator>Graber, Kelsey</creator><creator>O'Donnell, Kyle</creator><creator>Hamoda, Hesham M</creator><creator>Kimball, Kara</creator><creator>Rotenberg, Alexander</creator><creator>Oberman, Lindsay M</creator><creator>Pascual-Leone, Alvaro</creator><creator>Keshavan, Matcheri S</creator><creator>Duffy, Frank H</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20151201</creationdate><title>Early auditory processing evoked potentials (N100) show a continuum of blunting from clinical high risk to psychosis in a pediatric sample</title><author>Gonzalez-Heydrich, Joseph ; Bosquet Enlow, Michelle ; D'Angelo, Eugene ; Seidman, Larry J ; Gumlak, Sarah ; Kim, April ; Woodberry, Kristen A ; Rober, Ashley ; Tembulkar, Sahil ; Graber, Kelsey ; O'Donnell, Kyle ; Hamoda, Hesham M ; Kimball, Kara ; Rotenberg, Alexander ; Oberman, Lindsay M ; Pascual-Leone, Alvaro ; Keshavan, Matcheri S ; Duffy, Frank H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c518t-7f15872603c6b49af0e5ce628fd8894b89e7c479a9f44603069a535b4b7dda9c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Acoustic Stimulation</topic><topic>Adolescent</topic><topic>Analysis of Variance</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Clinical high risk</topic><topic>Early onset</topic><topic>Electroencephalography</topic><topic>Evoked Potentials, Auditory - physiology</topic><topic>Female</topic><topic>Humans</topic><topic>Linear Models</topic><topic>Male</topic><topic>N100</topic><topic>Psychiatric Status Rating Scales</topic><topic>Psychiatric/Mental Health</topic><topic>Psychosis</topic><topic>Schizophrenia</topic><topic>Schizophrenia - physiopathology</topic><topic>Superior temporal cortex</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gonzalez-Heydrich, Joseph</creatorcontrib><creatorcontrib>Bosquet Enlow, Michelle</creatorcontrib><creatorcontrib>D'Angelo, Eugene</creatorcontrib><creatorcontrib>Seidman, Larry J</creatorcontrib><creatorcontrib>Gumlak, Sarah</creatorcontrib><creatorcontrib>Kim, April</creatorcontrib><creatorcontrib>Woodberry, Kristen A</creatorcontrib><creatorcontrib>Rober, Ashley</creatorcontrib><creatorcontrib>Tembulkar, Sahil</creatorcontrib><creatorcontrib>Graber, Kelsey</creatorcontrib><creatorcontrib>O'Donnell, Kyle</creatorcontrib><creatorcontrib>Hamoda, Hesham M</creatorcontrib><creatorcontrib>Kimball, Kara</creatorcontrib><creatorcontrib>Rotenberg, Alexander</creatorcontrib><creatorcontrib>Oberman, Lindsay M</creatorcontrib><creatorcontrib>Pascual-Leone, Alvaro</creatorcontrib><creatorcontrib>Keshavan, Matcheri S</creatorcontrib><creatorcontrib>Duffy, Frank H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Schizophrenia research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gonzalez-Heydrich, Joseph</au><au>Bosquet Enlow, Michelle</au><au>D'Angelo, Eugene</au><au>Seidman, Larry J</au><au>Gumlak, Sarah</au><au>Kim, April</au><au>Woodberry, Kristen A</au><au>Rober, Ashley</au><au>Tembulkar, Sahil</au><au>Graber, Kelsey</au><au>O'Donnell, Kyle</au><au>Hamoda, Hesham M</au><au>Kimball, Kara</au><au>Rotenberg, Alexander</au><au>Oberman, Lindsay M</au><au>Pascual-Leone, Alvaro</au><au>Keshavan, Matcheri S</au><au>Duffy, Frank H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Early auditory processing evoked potentials (N100) show a continuum of blunting from clinical high risk to psychosis in a pediatric sample</atitle><jtitle>Schizophrenia research</jtitle><addtitle>Schizophr Res</addtitle><date>2015-12-01</date><risdate>2015</risdate><volume>169</volume><issue>1</issue><spage>340</spage><epage>345</epage><pages>340-345</pages><issn>0920-9964</issn><eissn>1573-2509</eissn><abstract>AbstractBackgroundThe N100 is a negative deflection in the surface EEG approximately 100 ms after an auditory signal. It has been shown to be reduced in individuals with schizophrenia and those at clinical high risk (CHR). N100 blunting may index neural network dysfunction underlying psychotic symptoms. This phenomenon has received little attention in pediatric populations. MethodThis cross-sectional study compared the N100 response measured via the average EEG response at the left medial frontal position FC1 to 150 sinusoidal tones in participants ages 5 to 17 years with a CHR syndrome ( n= 29), a psychotic disorder ( n= 22), or healthy controls ( n= 17). ResultsLinear regression analyses that considered potential covariates (age, gender, handedness, family mental health history, medication usage) revealed decreasing N100 amplitude with increasing severity of psychotic symptomatology from healthy to CHR to psychotic level. ConclusionsLongitudinal assessment of the N100 in CHR children who do and do not develop psychosis will inform whether it predicts transition to psychosis and if its response to treatment predicts symptom change.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>26549629</pmid><doi>10.1016/j.schres.2015.10.037</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0920-9964 |
| ispartof | Schizophrenia research, 2015-12, Vol.169 (1), p.340-345 |
| issn | 0920-9964 1573-2509 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4821005 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Acoustic Stimulation Adolescent Analysis of Variance Child Child, Preschool Clinical high risk Early onset Electroencephalography Evoked Potentials, Auditory - physiology Female Humans Linear Models Male N100 Psychiatric Status Rating Scales Psychiatric/Mental Health Psychosis Schizophrenia Schizophrenia - physiopathology Superior temporal cortex |
| title | Early auditory processing evoked potentials (N100) show a continuum of blunting from clinical high risk to psychosis in a pediatric sample |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-16T00%3A31%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Early%20auditory%20processing%20evoked%20potentials%20(N100)%20show%20a%20continuum%20of%20blunting%20from%20clinical%20high%20risk%20to%20psychosis%20in%20a%20pediatric%20sample&rft.jtitle=Schizophrenia%20research&rft.au=Gonzalez-Heydrich,%20Joseph&rft.date=2015-12-01&rft.volume=169&rft.issue=1&rft.spage=340&rft.epage=345&rft.pages=340-345&rft.issn=0920-9964&rft.eissn=1573-2509&rft_id=info:doi/10.1016/j.schres.2015.10.037&rft_dat=%3Cproquest_pubme%3E1749992161%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1749992161&rft_id=info:pmid/26549629&rft_els_id=S0920996415300372&rfr_iscdi=true |