The development of allergic inflammation in a murine house dust mite asthma model is suppressed by synbiotic mixtures of non-digestible oligosaccharides and Bifidobacterium breve M-16V
Purpose The incidence and severity of allergic asthma is rising, and novel strategies to prevent or treat this disease are needed. This study investigated the effects of different mixtures of non-digestible oligosaccharides combined with Bifidobacterium breve M-16V ( BB ) on the development of aller...
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| Veröffentlicht in: | European journal of nutrition 2016-04, Vol.55 (3), p.1141-1151 |
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| creator | Verheijden, K. A. T. Willemsen, L. E. M. Braber, S. Leusink-Muis, T. Jeurink, P. V. Garssen, J. Kraneveld, A. D. Folkerts, G. |
| description | Purpose
The incidence and severity of allergic asthma is rising, and novel strategies to prevent or treat this disease are needed. This study investigated the effects of different mixtures of non-digestible oligosaccharides combined with
Bifidobacterium breve
M-16V (
BB
) on the development of allergic airway inflammation in an animal model for house dust mite (HDM)-induced allergic asthma.
Methods
BALB/c mice were sensitized intranasally (i.n.) with HDM and subsequently challenged (i.n.) with PBS or HDM while being fed diets containing different oligosaccharide mixtures in combination with
BB
or an isocaloric identical control diet. Bronchoalveolar lavage fluid (BALF) inflammatory cell influx, chemokine and cytokine concentrations in lung homogenates and supernatants of ex vivo HDM-restimulated lung cells were analyzed.
Results
The HDM-induced influx of eosinophils and lymphocytes was reduced by the diet containing the short-chain and long-chain fructo-oligosaccharides and
BB
(FF
BB
). In addition to the HDM-induced cell influx, concentrations of IL-33, CCL17, CCL22, IL-6, IL-13 and IL-5 were increased in supernatants of lung homogenates or BALF and IL-4, IFN-γ and IL-10 were increased in restimulated lung cell suspensions of HDM-allergic mice. The diet containing FF
BB
reduced IL-6, IFN-γ, IL-4 and IL-10 concentrations, whereas the combination of galacto-oligosaccharides and long-chain fructo-oligosaccharides with
BB
was less potent in this model.
Conclusion
These findings show that synbiotic dietary supplementation can affect respiratory allergic inflammation induced by HDM. The combination of FF
BB
was most effective in the prevention of HDM-induced airway inflammation in mice. |
| doi_str_mv | 10.1007/s00394-015-0928-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4819948</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1785237356</sourcerecordid><originalsourceid>FETCH-LOGICAL-c569t-707ed16fdc358c7ca17cd87026cf5f91eb0642752a3ea57f44e964d2444981683</originalsourceid><addsrcrecordid>eNp1kstu1TAQhiMEohd4ADbIEhs2ATvxJdkg0YoCUhGbwtZy7EmOK1-CnVScN-PxcHTKUUFiZVv_N__MWH9VvSD4DcFYvM0Ytz2tMWE17puu7h5Vp4S2vOYNYY-PdyxOqrOcbzHGTcvJ0-qk4aWSdOy0-nWzA2TgDlycPYQFxREp5yBNViMbRqe8V4uNoTyQQn5NNgDaxTWXsjUvyNsFkMrLzhc1GnDIZpTXeU6QMxg07FHeh8HGpRh6-3NZi7B1CTHUxk6QFzs4QNHZKWal9U4lawqigkEXdrQmDkovkOzq0ZDKpOhLTfj3Z9WTUbkMz-_P8-rb1Yeby0_19dePny_fX9ea8X6pBRZgCB-NblmnhVZEaNMJ3HA9srEnMGBOG8Ea1YJiYqQUek5NQyntO8K79rx6d_Cd18GD0eWPknJyTtartJdRWfm3EuxOTvFO0o70Pd0MXt8bpPhjLetKb7MG51SA8o2SiI41rWgZL-irf9DbuKZQ1iuUEF3LaYsLRQ6UTjHnBONxGILllgt5yIUsuZBbLuQ2xMuHWxwr_gShAM0ByEUKE6QHrf_r-httf8eI</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1777836430</pqid></control><display><type>article</type><title>The development of allergic inflammation in a murine house dust mite asthma model is suppressed by synbiotic mixtures of non-digestible oligosaccharides and Bifidobacterium breve M-16V</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Verheijden, K. A. T. ; Willemsen, L. E. M. ; Braber, S. ; Leusink-Muis, T. ; Jeurink, P. V. ; Garssen, J. ; Kraneveld, A. D. ; Folkerts, G.</creator><creatorcontrib>Verheijden, K. A. T. ; Willemsen, L. E. M. ; Braber, S. ; Leusink-Muis, T. ; Jeurink, P. V. ; Garssen, J. ; Kraneveld, A. D. ; Folkerts, G.</creatorcontrib><description>Purpose
The incidence and severity of allergic asthma is rising, and novel strategies to prevent or treat this disease are needed. This study investigated the effects of different mixtures of non-digestible oligosaccharides combined with
Bifidobacterium breve
M-16V (
BB
) on the development of allergic airway inflammation in an animal model for house dust mite (HDM)-induced allergic asthma.
Methods
BALB/c mice were sensitized intranasally (i.n.) with HDM and subsequently challenged (i.n.) with PBS or HDM while being fed diets containing different oligosaccharide mixtures in combination with
BB
or an isocaloric identical control diet. Bronchoalveolar lavage fluid (BALF) inflammatory cell influx, chemokine and cytokine concentrations in lung homogenates and supernatants of ex vivo HDM-restimulated lung cells were analyzed.
Results
The HDM-induced influx of eosinophils and lymphocytes was reduced by the diet containing the short-chain and long-chain fructo-oligosaccharides and
BB
(FF
BB
). In addition to the HDM-induced cell influx, concentrations of IL-33, CCL17, CCL22, IL-6, IL-13 and IL-5 were increased in supernatants of lung homogenates or BALF and IL-4, IFN-γ and IL-10 were increased in restimulated lung cell suspensions of HDM-allergic mice. The diet containing FF
BB
reduced IL-6, IFN-γ, IL-4 and IL-10 concentrations, whereas the combination of galacto-oligosaccharides and long-chain fructo-oligosaccharides with
BB
was less potent in this model.
Conclusion
These findings show that synbiotic dietary supplementation can affect respiratory allergic inflammation induced by HDM. The combination of FF
BB
was most effective in the prevention of HDM-induced airway inflammation in mice.</description><identifier>ISSN: 1436-6207</identifier><identifier>EISSN: 1436-6215</identifier><identifier>DOI: 10.1007/s00394-015-0928-8</identifier><identifier>PMID: 26003185</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Animals ; Asthma - immunology ; Asthma - therapy ; Bifidobacterium breve ; Bronchoalveolar Lavage Fluid - microbiology ; Chemistry ; Chemistry and Materials Science ; Chemokine CCL17 - metabolism ; Chemokine CCL22 - metabolism ; Dermatophagoides pteronyssinus ; Disease Models, Animal ; Eosinophils - metabolism ; Hypersensitivity - immunology ; Hypersensitivity - therapy ; Inflammation - immunology ; Inflammation - therapy ; Interferon-gamma - metabolism ; Interleukins - metabolism ; Lung - cytology ; Lung - metabolism ; Male ; Mice ; Mice, Inbred BALB C ; Nutrition ; Oligosaccharides - pharmacology ; Original Contribution ; Pyroglyphidae - immunology ; Synbiotics - administration & dosage</subject><ispartof>European journal of nutrition, 2016-04, Vol.55 (3), p.1141-1151</ispartof><rights>The Author(s) 2015</rights><rights>Springer-Verlag Berlin Heidelberg 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c569t-707ed16fdc358c7ca17cd87026cf5f91eb0642752a3ea57f44e964d2444981683</citedby><cites>FETCH-LOGICAL-c569t-707ed16fdc358c7ca17cd87026cf5f91eb0642752a3ea57f44e964d2444981683</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00394-015-0928-8$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00394-015-0928-8$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,315,781,785,886,27929,27930,41493,42562,51324</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26003185$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Verheijden, K. A. T.</creatorcontrib><creatorcontrib>Willemsen, L. E. M.</creatorcontrib><creatorcontrib>Braber, S.</creatorcontrib><creatorcontrib>Leusink-Muis, T.</creatorcontrib><creatorcontrib>Jeurink, P. V.</creatorcontrib><creatorcontrib>Garssen, J.</creatorcontrib><creatorcontrib>Kraneveld, A. D.</creatorcontrib><creatorcontrib>Folkerts, G.</creatorcontrib><title>The development of allergic inflammation in a murine house dust mite asthma model is suppressed by synbiotic mixtures of non-digestible oligosaccharides and Bifidobacterium breve M-16V</title><title>European journal of nutrition</title><addtitle>Eur J Nutr</addtitle><addtitle>Eur J Nutr</addtitle><description>Purpose
The incidence and severity of allergic asthma is rising, and novel strategies to prevent or treat this disease are needed. This study investigated the effects of different mixtures of non-digestible oligosaccharides combined with
Bifidobacterium breve
M-16V (
BB
) on the development of allergic airway inflammation in an animal model for house dust mite (HDM)-induced allergic asthma.
Methods
BALB/c mice were sensitized intranasally (i.n.) with HDM and subsequently challenged (i.n.) with PBS or HDM while being fed diets containing different oligosaccharide mixtures in combination with
BB
or an isocaloric identical control diet. Bronchoalveolar lavage fluid (BALF) inflammatory cell influx, chemokine and cytokine concentrations in lung homogenates and supernatants of ex vivo HDM-restimulated lung cells were analyzed.
Results
The HDM-induced influx of eosinophils and lymphocytes was reduced by the diet containing the short-chain and long-chain fructo-oligosaccharides and
BB
(FF
BB
). In addition to the HDM-induced cell influx, concentrations of IL-33, CCL17, CCL22, IL-6, IL-13 and IL-5 were increased in supernatants of lung homogenates or BALF and IL-4, IFN-γ and IL-10 were increased in restimulated lung cell suspensions of HDM-allergic mice. The diet containing FF
BB
reduced IL-6, IFN-γ, IL-4 and IL-10 concentrations, whereas the combination of galacto-oligosaccharides and long-chain fructo-oligosaccharides with
BB
was less potent in this model.
Conclusion
These findings show that synbiotic dietary supplementation can affect respiratory allergic inflammation induced by HDM. The combination of FF
BB
was most effective in the prevention of HDM-induced airway inflammation in mice.</description><subject>Animals</subject><subject>Asthma - immunology</subject><subject>Asthma - therapy</subject><subject>Bifidobacterium breve</subject><subject>Bronchoalveolar Lavage Fluid - microbiology</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chemokine CCL17 - metabolism</subject><subject>Chemokine CCL22 - metabolism</subject><subject>Dermatophagoides pteronyssinus</subject><subject>Disease Models, Animal</subject><subject>Eosinophils - metabolism</subject><subject>Hypersensitivity - immunology</subject><subject>Hypersensitivity - therapy</subject><subject>Inflammation - immunology</subject><subject>Inflammation - therapy</subject><subject>Interferon-gamma - metabolism</subject><subject>Interleukins - metabolism</subject><subject>Lung - cytology</subject><subject>Lung - metabolism</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Nutrition</subject><subject>Oligosaccharides - pharmacology</subject><subject>Original Contribution</subject><subject>Pyroglyphidae - immunology</subject><subject>Synbiotics - administration & dosage</subject><issn>1436-6207</issn><issn>1436-6215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp1kstu1TAQhiMEohd4ADbIEhs2ATvxJdkg0YoCUhGbwtZy7EmOK1-CnVScN-PxcHTKUUFiZVv_N__MWH9VvSD4DcFYvM0Ytz2tMWE17puu7h5Vp4S2vOYNYY-PdyxOqrOcbzHGTcvJ0-qk4aWSdOy0-nWzA2TgDlycPYQFxREp5yBNViMbRqe8V4uNoTyQQn5NNgDaxTWXsjUvyNsFkMrLzhc1GnDIZpTXeU6QMxg07FHeh8HGpRh6-3NZi7B1CTHUxk6QFzs4QNHZKWal9U4lawqigkEXdrQmDkovkOzq0ZDKpOhLTfj3Z9WTUbkMz-_P8-rb1Yeby0_19dePny_fX9ea8X6pBRZgCB-NblmnhVZEaNMJ3HA9srEnMGBOG8Ea1YJiYqQUek5NQyntO8K79rx6d_Cd18GD0eWPknJyTtartJdRWfm3EuxOTvFO0o70Pd0MXt8bpPhjLetKb7MG51SA8o2SiI41rWgZL-irf9DbuKZQ1iuUEF3LaYsLRQ6UTjHnBONxGILllgt5yIUsuZBbLuQ2xMuHWxwr_gShAM0ByEUKE6QHrf_r-httf8eI</recordid><startdate>20160401</startdate><enddate>20160401</enddate><creator>Verheijden, K. A. T.</creator><creator>Willemsen, L. E. M.</creator><creator>Braber, S.</creator><creator>Leusink-Muis, T.</creator><creator>Jeurink, P. V.</creator><creator>Garssen, J.</creator><creator>Kraneveld, A. D.</creator><creator>Folkerts, G.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RQ</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7QL</scope><scope>C1K</scope><scope>5PM</scope></search><sort><creationdate>20160401</creationdate><title>The development of allergic inflammation in a murine house dust mite asthma model is suppressed by synbiotic mixtures of non-digestible oligosaccharides and Bifidobacterium breve M-16V</title><author>Verheijden, K. A. T. ; Willemsen, L. E. M. ; Braber, S. ; Leusink-Muis, T. ; Jeurink, P. V. ; Garssen, J. ; Kraneveld, A. D. ; Folkerts, G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c569t-707ed16fdc358c7ca17cd87026cf5f91eb0642752a3ea57f44e964d2444981683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Asthma - immunology</topic><topic>Asthma - therapy</topic><topic>Bifidobacterium breve</topic><topic>Bronchoalveolar Lavage Fluid - microbiology</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chemokine CCL17 - metabolism</topic><topic>Chemokine CCL22 - metabolism</topic><topic>Dermatophagoides pteronyssinus</topic><topic>Disease Models, Animal</topic><topic>Eosinophils - metabolism</topic><topic>Hypersensitivity - immunology</topic><topic>Hypersensitivity - therapy</topic><topic>Inflammation - immunology</topic><topic>Inflammation - therapy</topic><topic>Interferon-gamma - metabolism</topic><topic>Interleukins - metabolism</topic><topic>Lung - cytology</topic><topic>Lung - metabolism</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Nutrition</topic><topic>Oligosaccharides - pharmacology</topic><topic>Original Contribution</topic><topic>Pyroglyphidae - immunology</topic><topic>Synbiotics - administration & dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Verheijden, K. A. T.</creatorcontrib><creatorcontrib>Willemsen, L. E. M.</creatorcontrib><creatorcontrib>Braber, S.</creatorcontrib><creatorcontrib>Leusink-Muis, T.</creatorcontrib><creatorcontrib>Jeurink, P. V.</creatorcontrib><creatorcontrib>Garssen, J.</creatorcontrib><creatorcontrib>Kraneveld, A. D.</creatorcontrib><creatorcontrib>Folkerts, G.</creatorcontrib><collection>Springer Nature OA/Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Career & Technical Education Database</collection><collection>Nursing & Allied Health Database</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>European journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Verheijden, K. A. T.</au><au>Willemsen, L. E. M.</au><au>Braber, S.</au><au>Leusink-Muis, T.</au><au>Jeurink, P. V.</au><au>Garssen, J.</au><au>Kraneveld, A. D.</au><au>Folkerts, G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The development of allergic inflammation in a murine house dust mite asthma model is suppressed by synbiotic mixtures of non-digestible oligosaccharides and Bifidobacterium breve M-16V</atitle><jtitle>European journal of nutrition</jtitle><stitle>Eur J Nutr</stitle><addtitle>Eur J Nutr</addtitle><date>2016-04-01</date><risdate>2016</risdate><volume>55</volume><issue>3</issue><spage>1141</spage><epage>1151</epage><pages>1141-1151</pages><issn>1436-6207</issn><eissn>1436-6215</eissn><abstract>Purpose
The incidence and severity of allergic asthma is rising, and novel strategies to prevent or treat this disease are needed. This study investigated the effects of different mixtures of non-digestible oligosaccharides combined with
Bifidobacterium breve
M-16V (
BB
) on the development of allergic airway inflammation in an animal model for house dust mite (HDM)-induced allergic asthma.
Methods
BALB/c mice were sensitized intranasally (i.n.) with HDM and subsequently challenged (i.n.) with PBS or HDM while being fed diets containing different oligosaccharide mixtures in combination with
BB
or an isocaloric identical control diet. Bronchoalveolar lavage fluid (BALF) inflammatory cell influx, chemokine and cytokine concentrations in lung homogenates and supernatants of ex vivo HDM-restimulated lung cells were analyzed.
Results
The HDM-induced influx of eosinophils and lymphocytes was reduced by the diet containing the short-chain and long-chain fructo-oligosaccharides and
BB
(FF
BB
). In addition to the HDM-induced cell influx, concentrations of IL-33, CCL17, CCL22, IL-6, IL-13 and IL-5 were increased in supernatants of lung homogenates or BALF and IL-4, IFN-γ and IL-10 were increased in restimulated lung cell suspensions of HDM-allergic mice. The diet containing FF
BB
reduced IL-6, IFN-γ, IL-4 and IL-10 concentrations, whereas the combination of galacto-oligosaccharides and long-chain fructo-oligosaccharides with
BB
was less potent in this model.
Conclusion
These findings show that synbiotic dietary supplementation can affect respiratory allergic inflammation induced by HDM. The combination of FF
BB
was most effective in the prevention of HDM-induced airway inflammation in mice.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>26003185</pmid><doi>10.1007/s00394-015-0928-8</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1436-6207 |
| ispartof | European journal of nutrition, 2016-04, Vol.55 (3), p.1141-1151 |
| issn | 1436-6207 1436-6215 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4819948 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Animals Asthma - immunology Asthma - therapy Bifidobacterium breve Bronchoalveolar Lavage Fluid - microbiology Chemistry Chemistry and Materials Science Chemokine CCL17 - metabolism Chemokine CCL22 - metabolism Dermatophagoides pteronyssinus Disease Models, Animal Eosinophils - metabolism Hypersensitivity - immunology Hypersensitivity - therapy Inflammation - immunology Inflammation - therapy Interferon-gamma - metabolism Interleukins - metabolism Lung - cytology Lung - metabolism Male Mice Mice, Inbred BALB C Nutrition Oligosaccharides - pharmacology Original Contribution Pyroglyphidae - immunology Synbiotics - administration & dosage |
| title | The development of allergic inflammation in a murine house dust mite asthma model is suppressed by synbiotic mixtures of non-digestible oligosaccharides and Bifidobacterium breve M-16V |
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