Asymmetric Enzymatic Synthesis of Allylic Amines: A Sigmatropic Rearrangement Strategy

Sigmatropic rearrangements, while rare in biology, offer opportunities for the efficient and selective synthesis of complex chemical motifs. A “P411” serine‐ligated variant of cytochrome P450BM3 has been engineered to initiate a sulfimidation/[2,3]‐sigmatropic rearrangement sequence in whole E. coli...

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Veröffentlicht in:	Angewandte Chemie International Edition 2016-04, Vol.55 (15), p.4711-4715
Hauptverfasser:	Prier, Christopher K., Hyster, Todd K., Farwell, Christopher C., Huang, Audrey, Arnold, Frances H.
Format:	Artikel
Sprache:	eng
Schlagworte:	amination Amines Amines - chemical synthesis Asymmetry biocatalysis Biology Catalysts Chemical synthesis Cytochrome cytochrome P450 directed evolution E coli Enantiomers Enzymatic synthesis Enzymes Enzymes - chemistry Mutation nitrene transfer Serine Strategy Sulfides
Online-Zugang:	Volltext
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