Serum estradiol:oocyte ratio as a predictor of reproductive outcome: an analysis of data from >9000 IVF cycles in the Republic of Ireland
Purpose The purpose of this study was to evaluate the serum estradiol (E2) per oocyte ratio (EOR) as a function of selected embryology events and reproductive outcomes with IVF. Methods This retrospective analysis included all IVF cycles where oocyte collection and fresh transfer occurred between Ja...
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| Veröffentlicht in: | Journal of assisted reproduction and genetics 2016-04, Vol.33 (4), p.481-488 |
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| creator | Vaughan, Denis A. Harrity, Conor Sills, E. Scott Mocanu, Edgar V. |
| description | Purpose
The purpose of this study was to evaluate the serum estradiol (E2) per oocyte ratio (EOR) as a function of selected embryology events and reproductive outcomes with IVF.
Methods
This retrospective analysis included all IVF cycles where oocyte collection and fresh transfer occurred between January 2001 and November 2012 at a single institution. Patients were divided by three age groups ( 1500 was 3.4 (
p
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| doi_str_mv | 10.1007/s10815-016-0664-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4818638</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1780525383</sourcerecordid><originalsourceid>FETCH-LOGICAL-c503t-d731202e474a53390bf4e6b78b71da5b6bc522baf827212b3b6c0688558ec1f93</originalsourceid><addsrcrecordid>eNqNkt1qFTEUhQdRbK0-gDcS8Mab0Z1k8jO9KEixeqAg-HcbksyeNmVmckxmSs8j-NZmPLVUQRACCewva--1WVX1nMJrCqDeZAqaihqorEHKpr55UB1SoXitOIeH5Q1C19BIfVA9yfkKAFrN-OPqgEktGOPssPrxGdMyEsxzsl2Iw3GMfjcjSXYOkdhMLNkm7IKfYyKxJwm3KXaLn8M1krjMPo54TOxUjh12OeQV6uxsSZ_iSE7a0pRsvp0Rv_MDZhImMl8i-YTbxQ3Br_Qm4WCn7mn1qLdDxme391H19ezdl9MP9fnH95vTt-e1F8DnulOcMmDYqMYKzltwfYPSKe0U7axw0vlizdleM8Uoc9xJD1JrITR62rf8qDrZ65YJRuw8TsX6YLYpjDbtTLTB_FmZwqW5iNem0VRLrovAq1uBFL8vZXNmDNnjUExgXLKhSoNgopD_gSrN27aRsqAv_0Kv4pLKUn9RSjNo6UrRPeVTzDlhfzc3BbNmwuwzYUomzJoJc1P-vLhv-O7H7xAUgO2BXErTBaZ7rf-p-hNpmMJ-</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1777820916</pqid></control><display><type>article</type><title>Serum estradiol:oocyte ratio as a predictor of reproductive outcome: an analysis of data from >9000 IVF cycles in the Republic of Ireland</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>SpringerLink Journals - AutoHoldings</source><creator>Vaughan, Denis A. ; Harrity, Conor ; Sills, E. Scott ; Mocanu, Edgar V.</creator><creatorcontrib>Vaughan, Denis A. ; Harrity, Conor ; Sills, E. Scott ; Mocanu, Edgar V.</creatorcontrib><description>Purpose
The purpose of this study was to evaluate the serum estradiol (E2) per oocyte ratio (EOR) as a function of selected embryology events and reproductive outcomes with IVF.
Methods
This retrospective analysis included all IVF cycles where oocyte collection and fresh transfer occurred between January 2001 and November 2012 at a single institution. Patients were divided by three age groups (<35, 35–39, and ≥40 years) and further stratified into nine groups based on EOR (measured in pmol/L/oocyte). Terminal serum E2 (pmol/mL) was recorded on day of hCG trigger administration, and fertilization rate, cleavage rate, number of good quality embryos, and reproductive outcomes were recorded for each IVF cycle.
Results
During the study interval, 9109 oocyte retrievals were performed for 5499 IVF patients (mean = 1.7 cycles/patient). A total of 63.4 % of transfers were performed on day 3 (
n
= 4926), while 36.6 % were carried out on day 5 (
n
= 2843). Clinical pregnancy rates were highest in patients with EOR of 250–750 and declined as this ratio increased, independent of patient age. While the odds ratio (OR) for clinical pregnancy where EOR = 250–750 vs. EOR > 1500 was 3.4 (
p
< 0.001; 95 % CI 2.67–4.34), no statistically significant correlation was seen in fertilization, cleavage rates or number of good quality embryos as a function of EOR.
Conclusions
Predicting reproductive outcomes with IVF has great utility both for patients and providers. The former have the opportunity to build realistic expectations, and the latter are better able to counsel according to measured clinical parameters. A better understanding of follicular dynamics and ovarian response to gonadotropin stimulation could optimize IVF treatments going forward.</description><identifier>ISSN: 1058-0468</identifier><identifier>EISSN: 1573-7330</identifier><identifier>DOI: 10.1007/s10815-016-0664-x</identifier><identifier>PMID: 26852232</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adult ; Assisted Reproduction Technologies ; Embryo Transfer ; Embryos ; Estradiol - blood ; Female ; Fertilization in Vitro - methods ; Gynecology ; Hospitals ; Human Genetics ; Humans ; Medical records ; Medicine ; Medicine & Public Health ; Middle Aged ; Obstetrics ; Oocyte Retrieval ; Oocytes - cytology ; Ovaries ; Ovulation Induction ; Patients ; Pregnancy ; Pregnancy Rate ; Progesterone - blood ; Reproductive Medicine ; Reproductive Techniques, Assisted ; Success ; Ultrasonic imaging</subject><ispartof>Journal of assisted reproduction and genetics, 2016-04, Vol.33 (4), p.481-488</ispartof><rights>Springer Science+Business Media New York 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c503t-d731202e474a53390bf4e6b78b71da5b6bc522baf827212b3b6c0688558ec1f93</citedby><cites>FETCH-LOGICAL-c503t-d731202e474a53390bf4e6b78b71da5b6bc522baf827212b3b6c0688558ec1f93</cites><orcidid>0000-0001-7334-1031</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818638/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818638/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,41464,42533,51294,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26852232$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vaughan, Denis A.</creatorcontrib><creatorcontrib>Harrity, Conor</creatorcontrib><creatorcontrib>Sills, E. Scott</creatorcontrib><creatorcontrib>Mocanu, Edgar V.</creatorcontrib><title>Serum estradiol:oocyte ratio as a predictor of reproductive outcome: an analysis of data from >9000 IVF cycles in the Republic of Ireland</title><title>Journal of assisted reproduction and genetics</title><addtitle>J Assist Reprod Genet</addtitle><addtitle>J Assist Reprod Genet</addtitle><description>Purpose
The purpose of this study was to evaluate the serum estradiol (E2) per oocyte ratio (EOR) as a function of selected embryology events and reproductive outcomes with IVF.
Methods
This retrospective analysis included all IVF cycles where oocyte collection and fresh transfer occurred between January 2001 and November 2012 at a single institution. Patients were divided by three age groups (<35, 35–39, and ≥40 years) and further stratified into nine groups based on EOR (measured in pmol/L/oocyte). Terminal serum E2 (pmol/mL) was recorded on day of hCG trigger administration, and fertilization rate, cleavage rate, number of good quality embryos, and reproductive outcomes were recorded for each IVF cycle.
Results
During the study interval, 9109 oocyte retrievals were performed for 5499 IVF patients (mean = 1.7 cycles/patient). A total of 63.4 % of transfers were performed on day 3 (
n
= 4926), while 36.6 % were carried out on day 5 (
n
= 2843). Clinical pregnancy rates were highest in patients with EOR of 250–750 and declined as this ratio increased, independent of patient age. While the odds ratio (OR) for clinical pregnancy where EOR = 250–750 vs. EOR > 1500 was 3.4 (
p
< 0.001; 95 % CI 2.67–4.34), no statistically significant correlation was seen in fertilization, cleavage rates or number of good quality embryos as a function of EOR.
Conclusions
Predicting reproductive outcomes with IVF has great utility both for patients and providers. The former have the opportunity to build realistic expectations, and the latter are better able to counsel according to measured clinical parameters. A better understanding of follicular dynamics and ovarian response to gonadotropin stimulation could optimize IVF treatments going forward.</description><subject>Adult</subject><subject>Assisted Reproduction Technologies</subject><subject>Embryo Transfer</subject><subject>Embryos</subject><subject>Estradiol - blood</subject><subject>Female</subject><subject>Fertilization in Vitro - methods</subject><subject>Gynecology</subject><subject>Hospitals</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Medical records</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Obstetrics</subject><subject>Oocyte Retrieval</subject><subject>Oocytes - cytology</subject><subject>Ovaries</subject><subject>Ovulation Induction</subject><subject>Patients</subject><subject>Pregnancy</subject><subject>Pregnancy Rate</subject><subject>Progesterone - blood</subject><subject>Reproductive Medicine</subject><subject>Reproductive Techniques, Assisted</subject><subject>Success</subject><subject>Ultrasonic imaging</subject><issn>1058-0468</issn><issn>1573-7330</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkt1qFTEUhQdRbK0-gDcS8Mab0Z1k8jO9KEixeqAg-HcbksyeNmVmckxmSs8j-NZmPLVUQRACCewva--1WVX1nMJrCqDeZAqaihqorEHKpr55UB1SoXitOIeH5Q1C19BIfVA9yfkKAFrN-OPqgEktGOPssPrxGdMyEsxzsl2Iw3GMfjcjSXYOkdhMLNkm7IKfYyKxJwm3KXaLn8M1krjMPo54TOxUjh12OeQV6uxsSZ_iSE7a0pRsvp0Rv_MDZhImMl8i-YTbxQ3Br_Qm4WCn7mn1qLdDxme391H19ezdl9MP9fnH95vTt-e1F8DnulOcMmDYqMYKzltwfYPSKe0U7axw0vlizdleM8Uoc9xJD1JrITR62rf8qDrZ65YJRuw8TsX6YLYpjDbtTLTB_FmZwqW5iNem0VRLrovAq1uBFL8vZXNmDNnjUExgXLKhSoNgopD_gSrN27aRsqAv_0Kv4pLKUn9RSjNo6UrRPeVTzDlhfzc3BbNmwuwzYUomzJoJc1P-vLhv-O7H7xAUgO2BXErTBaZ7rf-p-hNpmMJ-</recordid><startdate>20160401</startdate><enddate>20160401</enddate><creator>Vaughan, Denis A.</creator><creator>Harrity, Conor</creator><creator>Sills, E. Scott</creator><creator>Mocanu, Edgar V.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-7334-1031</orcidid></search><sort><creationdate>20160401</creationdate><title>Serum estradiol:oocyte ratio as a predictor of reproductive outcome: an analysis of data from >9000 IVF cycles in the Republic of Ireland</title><author>Vaughan, Denis A. ; Harrity, Conor ; Sills, E. Scott ; Mocanu, Edgar V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c503t-d731202e474a53390bf4e6b78b71da5b6bc522baf827212b3b6c0688558ec1f93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Assisted Reproduction Technologies</topic><topic>Embryo Transfer</topic><topic>Embryos</topic><topic>Estradiol - blood</topic><topic>Female</topic><topic>Fertilization in Vitro - methods</topic><topic>Gynecology</topic><topic>Hospitals</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Medical records</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Obstetrics</topic><topic>Oocyte Retrieval</topic><topic>Oocytes - cytology</topic><topic>Ovaries</topic><topic>Ovulation Induction</topic><topic>Patients</topic><topic>Pregnancy</topic><topic>Pregnancy Rate</topic><topic>Progesterone - blood</topic><topic>Reproductive Medicine</topic><topic>Reproductive Techniques, Assisted</topic><topic>Success</topic><topic>Ultrasonic imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vaughan, Denis A.</creatorcontrib><creatorcontrib>Harrity, Conor</creatorcontrib><creatorcontrib>Sills, E. 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Scott</au><au>Mocanu, Edgar V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum estradiol:oocyte ratio as a predictor of reproductive outcome: an analysis of data from >9000 IVF cycles in the Republic of Ireland</atitle><jtitle>Journal of assisted reproduction and genetics</jtitle><stitle>J Assist Reprod Genet</stitle><addtitle>J Assist Reprod Genet</addtitle><date>2016-04-01</date><risdate>2016</risdate><volume>33</volume><issue>4</issue><spage>481</spage><epage>488</epage><pages>481-488</pages><issn>1058-0468</issn><eissn>1573-7330</eissn><abstract>Purpose
The purpose of this study was to evaluate the serum estradiol (E2) per oocyte ratio (EOR) as a function of selected embryology events and reproductive outcomes with IVF.
Methods
This retrospective analysis included all IVF cycles where oocyte collection and fresh transfer occurred between January 2001 and November 2012 at a single institution. Patients were divided by three age groups (<35, 35–39, and ≥40 years) and further stratified into nine groups based on EOR (measured in pmol/L/oocyte). Terminal serum E2 (pmol/mL) was recorded on day of hCG trigger administration, and fertilization rate, cleavage rate, number of good quality embryos, and reproductive outcomes were recorded for each IVF cycle.
Results
During the study interval, 9109 oocyte retrievals were performed for 5499 IVF patients (mean = 1.7 cycles/patient). A total of 63.4 % of transfers were performed on day 3 (
n
= 4926), while 36.6 % were carried out on day 5 (
n
= 2843). Clinical pregnancy rates were highest in patients with EOR of 250–750 and declined as this ratio increased, independent of patient age. While the odds ratio (OR) for clinical pregnancy where EOR = 250–750 vs. EOR > 1500 was 3.4 (
p
< 0.001; 95 % CI 2.67–4.34), no statistically significant correlation was seen in fertilization, cleavage rates or number of good quality embryos as a function of EOR.
Conclusions
Predicting reproductive outcomes with IVF has great utility both for patients and providers. The former have the opportunity to build realistic expectations, and the latter are better able to counsel according to measured clinical parameters. A better understanding of follicular dynamics and ovarian response to gonadotropin stimulation could optimize IVF treatments going forward.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>26852232</pmid><doi>10.1007/s10815-016-0664-x</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-7334-1031</orcidid><oa>free_for_read</oa></addata></record> |
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| issn | 1058-0468 1573-7330 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; SpringerLink Journals - AutoHoldings |
| subjects | Adult Assisted Reproduction Technologies Embryo Transfer Embryos Estradiol - blood Female Fertilization in Vitro - methods Gynecology Hospitals Human Genetics Humans Medical records Medicine Medicine & Public Health Middle Aged Obstetrics Oocyte Retrieval Oocytes - cytology Ovaries Ovulation Induction Patients Pregnancy Pregnancy Rate Progesterone - blood Reproductive Medicine Reproductive Techniques, Assisted Success Ultrasonic imaging |
| title | Serum estradiol:oocyte ratio as a predictor of reproductive outcome: an analysis of data from >9000 IVF cycles in the Republic of Ireland |
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