Renal Integrin-Linked Kinase Depletion Induces Kidney cGMP-Axis Upregulation: Consequences on Basal and Acutely Damaged Renal Function

Soluble guanylyl cyclase (sGC) is activated by nitric oxide (NO) and produces cGMP, which activates cGMP-dependent protein kinases (PKG) and is hydrolyzed by specific phosphodiesterases (PDE). The vasodilatory and cytoprotective capacity of cGMP-axis activation results in a therapeutic strategy for...

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Veröffentlicht in:	Molecular medicine (Cambridge, Mass.) Mass.), 2015-01, Vol.21 (1), p.873-885
Hauptverfasser:	Cano-Peñalver, José Luis, Griera, Mercedes, García-Jerez, Andrea, Hatem-Vaquero, Marco, Ruiz-Torres, María Piedad, Rodríguez-Puyol, Diego, Frutos, Sergio de, Rodríguez-Puyol, Manuel
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Experiments Kidneys Kinases Laboratories Phosphorylation Proteins Smooth muscle Urine
Online-Zugang:	Volltext
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