Bioengineering Thymus Organoids to Restore Thymic Function and Induce Donor-Specific Immune Tolerance to Allografts

One of the major obstacles in organ transplantation is to establish immune tolerance of allografts. Although immunosuppressive drugs can prevent graft rejection to a certain degree, their efficacies are limited, transient, and associated with severe side effects. Induction of thymic central toleranc...

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Veröffentlicht in:	Molecular therapy 2015-07, Vol.23 (7), p.1262-1277
Hauptverfasser:	Fan, Yong, Tajima, Asako, Goh, Saik Kia, Geng, Xuehui, Gualtierotti, Giulio, Grupillo, Maria, Coppola, Antonina, Bertera, Suzanne, Rudert, William A, Banerjee, Ipsita, Bottino, Rita, Trucco, Massimo
Format:	Artikel
Sprache:	eng
Schlagworte:	Allografts - immunology Animals Bioengineering Epithelial Cells - cytology Epithelial Cells - immunology Immune Tolerance - immunology Mice Organoids - immunology Original Regenerative Medicine Thymus Gland - cytology Thymus Gland - growth & development Thymus Gland - immunology Transplantation, Homologous
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