THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia

Characterization of previously described intraflagellar transport (IFT) mouse mutants has led to the proposition that normal primary cilia are required for mammalian cells to respond to the sonic hedgehog (SHH) signal. Here we describe an N -ethyl- N -nitrosourea–induced mutant mouse, alien ( aln ),...

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Veröffentlicht in:	Nature genetics 2008-04, Vol.40 (4), p.403-410
Hauptverfasser:	Tran, Pamela V, Haycraft, Courtney J, Besschetnova, Tatiana Y, Turbe-Doan, Annick, Stottmann, Rolf W, Herron, Bruce J, Chesebro, Allyson L, Qiu, Haiyan, Scherz, Paul J, Shah, Jagesh V, Yoder, Bradley K, Beier, David R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - physiology Agriculture Alkylating Agents - toxicity Amino Acid Sequence Animal Genetics and Genomics Animals Biological and medical sciences Biological Transport Biomedical and Life Sciences Biomedicine Blotting, Western Caenorhabditis elegans Cancer Research Cell physiology Cells, Cultured Chlamydomonas reinhardtii Cilia - metabolism Cilia and ciliary motion Cloning, Molecular Ethylnitrosourea - toxicity Female Fibroblasts - metabolism Fundamental and applied biological sciences. Psychology Gene expression Gene Function Genes, Recessive Genetic aspects Genetics Genetics of eukaryotes. Biological and molecular evolution Hedgehog Proteins - metabolism Hedgehogs Human Genetics In Situ Hybridization Luminescent Proteins - genetics Luminescent Proteins - metabolism Male Mammals Mice Mice, Knockout Molecular and cellular biology Molecular Sequence Data Mutagenesis Mutants Mutation Oncogene Proteins - genetics Oncogene Proteins - metabolism Physiological aspects Proteins Rodents Sequence Homology, Amino Acid Signal Transduction Spinal Cord - metabolism Trans-Activators - genetics Trans-Activators - metabolism Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism Zinc Finger Protein GLI1
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