Oral Delivery of Particulate Transforming Growth Factor Beta 1 and All-Trans Retinoic Acid Reduces Gut Inflammation in Murine Models of Inflammatory Bowel Disease

Background and aims: We investigated oral delivery of transforming growth factor beta 1 [TGFβ]- and all-trans retinoic acid [ATRA]-loaded microspheres as therapy for gut inflammation in murine models of inflammatory bowel disease [IBD]. Methods: ATRA and TGFβ were separately encapsulated in poly [la...

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Veröffentlicht in:	Journal of Crohn's and colitis 2015-08, Vol.9 (8), p.647-658
Hauptverfasser:	Conway, Thomas F., Hammer, Laura, Furtado, Stacia, Mathiowitz, Edith, Nicoletti, Ferdinando, Mangano, Katia, Egilmez, Nejat K., Auci, Dominick L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - therapeutic use Biomarkers - metabolism Drug Administration Schedule Drug Therapy, Combination Female Inflammatory Bowel Diseases - drug therapy Inflammatory Bowel Diseases - metabolism Inflammatory Bowel Diseases - pathology Intestinal Mucosa - metabolism Intestinal Mucosa - pathology Male Mice Mice, Inbred BALB C Mice, SCID Microspheres Original Transforming Growth Factor beta - administration & dosage Transforming Growth Factor beta - therapeutic use Treatment Outcome Tretinoin - administration & dosage Tretinoin - therapeutic use
Online-Zugang:	Volltext
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