Clinical Validation and Implementation of a Targeted Next-Generation Sequencing Assay to Detect Somatic Variants in Non-Small Cell Lung, Melanoma, and Gastrointestinal Malignancies

We tested and clinically validated a targeted next-generation sequencing (NGS) mutation panel using 80 formalin-fixed, paraffin-embedded (FFPE) tumor samples. Forty non-small cell lung carcinoma (NSCLC), 30 melanoma, and 30 gastrointestinal (12 colonic, 10 gastric, and 8 pancreatic adenocarcinoma) F...

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Veröffentlicht in:	The Journal of molecular diagnostics : JMD 2016-03, Vol.18 (2), p.299-315
Hauptverfasser:	Fisher, Kevin E, Zhang, Linsheng, Wang, Jason, Smith, Geoffrey H, Newman, Scott, Schneider, Thomas M, Pillai, Rathi N, Kudchadkar, Ragini R, Owonikoko, Taofeek K, Ramalingam, Suresh S, Lawson, David H, Delman, Keith A, El-Rayes, Bassel F, Wilson, Malania M, Sullivan, H. Clifford, Morrison, Annie S, Balci, Serdar, Adsay, N. Volkan, Gal, Anthony A, Sica, Gabriel L, Saxe, Debra F, Mann, Karen P, Hill, Charles E, Khuri, Fadlo R, Rossi, Michael R
Format:	Artikel
Sprache:	eng
Schlagworte:	Carcinoma, Non-Small-Cell Lung - genetics Gastrointestinal Neoplasms - genetics High-Throughput Nucleotide Sequencing - methods Humans In Situ Hybridization, Fluorescence Limit of Detection Lung Neoplasms - genetics Melanoma - genetics Multiplex Polymerase Chain Reaction - methods Multiplex Polymerase Chain Reaction - standards Mutation Paraffin Embedding Pathology Quality Control Receptor, Epidermal Growth Factor - genetics Receptor, ErbB-2 - genetics Regular Sensitivity and Specificity Tumor Suppressor Protein p53 - genetics
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