Clinical MRSA isolates from skin and soft tissue infections show increased in vitro production of phenol soluble modulins
Summary Background Phenol-soluble modulins (PSMs) are amphipathic, pro-inflammatory proteins secreted by most Staphylococcus aureus isolates. This study tested the hypothesis that in vitro PSM production levels are associated with specific clinical phenotypes. Methods 177 methicillin-resistant S. au...
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| creator | Berlon, Nicholas R Qi, Robert Sharma-Kuinkel, Batu K Joo, Hwang-Soo Park, Lawrence P George, Dennis Thaden, Joshua T Messina, Julia A Maskarinec, Stacey A Mueller-Premru, Manica Athan, Eugene Tattevin, Pierre Pericas, Juan M Woods, Christopher W Otto, Michael Fowler, Vance G |
| description | Summary Background Phenol-soluble modulins (PSMs) are amphipathic, pro-inflammatory proteins secreted by most Staphylococcus aureus isolates. This study tested the hypothesis that in vitro PSM production levels are associated with specific clinical phenotypes. Methods 177 methicillin-resistant S. aureus (MRSA) isolates from infective endocarditis (IE), skin and soft tissue infection (SSTI), and hospital-acquired/ventilator-associated pneumonia (HAP) were matched by geographic origin, then genotyped using spa -typing. In vitro PSM production was measured by high performance liquid chromatography/mass spectrometry. Statistical analysis was performed using Chi-squared or Kruskal–Wallis tests as appropriate. Results Spa type 1 was significantly more common in SSTI isolates (62.7% SSTI; 1.7% IE; 16.9% HAP; p |
| doi_str_mv | 10.1016/j.jinf.2015.06.005 |
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| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4816458</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0163445315002005</els_id><sourcerecordid>1713952544</sourcerecordid><originalsourceid>FETCH-LOGICAL-c576t-6c33cf5994e5772bbb47d7039f4d3ae6e5c4b21a283215c8298e978cc3346a183</originalsourceid><addsrcrecordid>eNp9kt1u1DAQhSMEotvCC3CBfMlNgn_zI6FK1aoUpCIkCteW40xYp1l78SSLytPwLDwZDrtUwAVXtjXnnBn5myx7xmjBKCtfDsXgfF9wylRBy4JS9SBbMSV4zivJH2arJBK5lEqcZKeIA6W0EU35ODvhJa0aXqlV9m09Ou-sGcm7DzcXxGEYzQRI-hi2BG-dJ8Z3BEM_kckhzkBSS7CTCx4JbsLX9LYRDEKXbj--790UA9nF0M2_RCT0ZLcBH8YUMs7tCGSbaqkpPske9WZEeHo8z7JPry8_rt_k1--v3q4vrnOrqnLKSyuE7VXTSFBVxdu2lVVXUdH0shMGSlBWtpwZXgvOlK15U0NT1TbZZGlYLc6y80Pubm630FnwUzSj3kW3NfFOB-P03xXvNvpz2GtZs1KqJeDFMSCGLzPgpLcOLYyj8RBm1KxiolFcSZmk_CC1MSBG6O_bMKoXaHrQCzS9QNO01AlaMj3_c8B7y29KSfDqIID0TXsHUaN14C10LiYWugvu__nn_9jtEfot3AEOYY4-AdBMI9dU3yxrs2wNU5TyJeAnG5HBDQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1713952544</pqid></control><display><type>article</type><title>Clinical MRSA isolates from skin and soft tissue infections show increased in vitro production of phenol soluble modulins</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Berlon, Nicholas R ; Qi, Robert ; Sharma-Kuinkel, Batu K ; Joo, Hwang-Soo ; Park, Lawrence P ; George, Dennis ; Thaden, Joshua T ; Messina, Julia A ; Maskarinec, Stacey A ; Mueller-Premru, Manica ; Athan, Eugene ; Tattevin, Pierre ; Pericas, Juan M ; Woods, Christopher W ; Otto, Michael ; Fowler, Vance G</creator><creatorcontrib>Berlon, Nicholas R ; Qi, Robert ; Sharma-Kuinkel, Batu K ; Joo, Hwang-Soo ; Park, Lawrence P ; George, Dennis ; Thaden, Joshua T ; Messina, Julia A ; Maskarinec, Stacey A ; Mueller-Premru, Manica ; Athan, Eugene ; Tattevin, Pierre ; Pericas, Juan M ; Woods, Christopher W ; Otto, Michael ; Fowler, Vance G</creatorcontrib><description>Summary Background Phenol-soluble modulins (PSMs) are amphipathic, pro-inflammatory proteins secreted by most Staphylococcus aureus isolates. This study tested the hypothesis that in vitro PSM production levels are associated with specific clinical phenotypes. Methods 177 methicillin-resistant S. aureus (MRSA) isolates from infective endocarditis (IE), skin and soft tissue infection (SSTI), and hospital-acquired/ventilator-associated pneumonia (HAP) were matched by geographic origin, then genotyped using spa -typing. In vitro PSM production was measured by high performance liquid chromatography/mass spectrometry. Statistical analysis was performed using Chi-squared or Kruskal–Wallis tests as appropriate. Results Spa type 1 was significantly more common in SSTI isolates (62.7% SSTI; 1.7% IE; 16.9% HAP; p < 0.0001) while HAP and IE isolates were more commonly spa type 2 (0% SSTI; 37.3% IE; 40.7% HAP; p < 0.0001). USA300 isolates produced the highest levels of PSMs in vitro . SSTI isolates produced significantly higher quantities of PSMα1-4, PSMβ1, and δ-toxin than other isolates (p < 0.001). These findings persisted when USA300 isolates were excluded from analysis. Conclusions Increased in vitro production of PSMs is associated with an SSTI clinical source. This significant association persisted after exclusion of USA300 genotype isolates from analysis, suggesting that PSMs play a particularly important role in the pathogenesis of SSTI as compared to other infection types.</description><identifier>ISSN: 0163-4453</identifier><identifier>EISSN: 1532-2742</identifier><identifier>DOI: 10.1016/j.jinf.2015.06.005</identifier><identifier>PMID: 26079275</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Anti-Bacterial Agents - pharmacology ; Bacterial Toxins - biosynthesis ; Bacterial Toxins - chemistry ; Community-Acquired Infections - microbiology ; Endocarditis ; Endocarditis, Bacterial - microbiology ; Genotype ; Humans ; Infectious Disease ; Methicillin-Resistant Staphylococcus aureus - genetics ; Methicillin-Resistant Staphylococcus aureus - immunology ; Methicillin-Resistant Staphylococcus aureus - isolation & purification ; Methicillin-Resistant Staphylococcus aureus - metabolism ; Microbial Sensitivity Tests ; MRSA ; Phenol soluble modulin ; Phenols ; Phenotype ; Pneumonia ; Pneumonia, Ventilator-Associated - microbiology ; Skin - microbiology ; Skin and soft tissue infection ; Soft Tissue Infections - microbiology ; Staphylococcal Skin Infections - metabolism ; Staphylococcal Skin Infections - microbiology</subject><ispartof>The Journal of infection, 2015-10, Vol.71 (4), p.447-457</ispartof><rights>2015</rights><rights>Copyright © 2015. Published by Elsevier Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c576t-6c33cf5994e5772bbb47d7039f4d3ae6e5c4b21a283215c8298e978cc3346a183</citedby><cites>FETCH-LOGICAL-c576t-6c33cf5994e5772bbb47d7039f4d3ae6e5c4b21a283215c8298e978cc3346a183</cites><orcidid>0000-0001-6445-7331 ; 0000-0003-4668-3225 ; 0000-0001-9838-6471 ; 0000-0001-6419-7883</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0163445315002005$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26079275$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Berlon, Nicholas R</creatorcontrib><creatorcontrib>Qi, Robert</creatorcontrib><creatorcontrib>Sharma-Kuinkel, Batu K</creatorcontrib><creatorcontrib>Joo, Hwang-Soo</creatorcontrib><creatorcontrib>Park, Lawrence P</creatorcontrib><creatorcontrib>George, Dennis</creatorcontrib><creatorcontrib>Thaden, Joshua T</creatorcontrib><creatorcontrib>Messina, Julia A</creatorcontrib><creatorcontrib>Maskarinec, Stacey A</creatorcontrib><creatorcontrib>Mueller-Premru, Manica</creatorcontrib><creatorcontrib>Athan, Eugene</creatorcontrib><creatorcontrib>Tattevin, Pierre</creatorcontrib><creatorcontrib>Pericas, Juan M</creatorcontrib><creatorcontrib>Woods, Christopher W</creatorcontrib><creatorcontrib>Otto, Michael</creatorcontrib><creatorcontrib>Fowler, Vance G</creatorcontrib><title>Clinical MRSA isolates from skin and soft tissue infections show increased in vitro production of phenol soluble modulins</title><title>The Journal of infection</title><addtitle>J Infect</addtitle><description>Summary Background Phenol-soluble modulins (PSMs) are amphipathic, pro-inflammatory proteins secreted by most Staphylococcus aureus isolates. This study tested the hypothesis that in vitro PSM production levels are associated with specific clinical phenotypes. Methods 177 methicillin-resistant S. aureus (MRSA) isolates from infective endocarditis (IE), skin and soft tissue infection (SSTI), and hospital-acquired/ventilator-associated pneumonia (HAP) were matched by geographic origin, then genotyped using spa -typing. In vitro PSM production was measured by high performance liquid chromatography/mass spectrometry. Statistical analysis was performed using Chi-squared or Kruskal–Wallis tests as appropriate. Results Spa type 1 was significantly more common in SSTI isolates (62.7% SSTI; 1.7% IE; 16.9% HAP; p < 0.0001) while HAP and IE isolates were more commonly spa type 2 (0% SSTI; 37.3% IE; 40.7% HAP; p < 0.0001). USA300 isolates produced the highest levels of PSMs in vitro . SSTI isolates produced significantly higher quantities of PSMα1-4, PSMβ1, and δ-toxin than other isolates (p < 0.001). These findings persisted when USA300 isolates were excluded from analysis. Conclusions Increased in vitro production of PSMs is associated with an SSTI clinical source. This significant association persisted after exclusion of USA300 genotype isolates from analysis, suggesting that PSMs play a particularly important role in the pathogenesis of SSTI as compared to other infection types.</description><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Bacterial Toxins - biosynthesis</subject><subject>Bacterial Toxins - chemistry</subject><subject>Community-Acquired Infections - microbiology</subject><subject>Endocarditis</subject><subject>Endocarditis, Bacterial - microbiology</subject><subject>Genotype</subject><subject>Humans</subject><subject>Infectious Disease</subject><subject>Methicillin-Resistant Staphylococcus aureus - genetics</subject><subject>Methicillin-Resistant Staphylococcus aureus - immunology</subject><subject>Methicillin-Resistant Staphylococcus aureus - isolation & purification</subject><subject>Methicillin-Resistant Staphylococcus aureus - metabolism</subject><subject>Microbial Sensitivity Tests</subject><subject>MRSA</subject><subject>Phenol soluble modulin</subject><subject>Phenols</subject><subject>Phenotype</subject><subject>Pneumonia</subject><subject>Pneumonia, Ventilator-Associated - microbiology</subject><subject>Skin - microbiology</subject><subject>Skin and soft tissue infection</subject><subject>Soft Tissue Infections - microbiology</subject><subject>Staphylococcal Skin Infections - metabolism</subject><subject>Staphylococcal Skin Infections - microbiology</subject><issn>0163-4453</issn><issn>1532-2742</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kt1u1DAQhSMEotvCC3CBfMlNgn_zI6FK1aoUpCIkCteW40xYp1l78SSLytPwLDwZDrtUwAVXtjXnnBn5myx7xmjBKCtfDsXgfF9wylRBy4JS9SBbMSV4zivJH2arJBK5lEqcZKeIA6W0EU35ODvhJa0aXqlV9m09Ou-sGcm7DzcXxGEYzQRI-hi2BG-dJ8Z3BEM_kckhzkBSS7CTCx4JbsLX9LYRDEKXbj--790UA9nF0M2_RCT0ZLcBH8YUMs7tCGSbaqkpPske9WZEeHo8z7JPry8_rt_k1--v3q4vrnOrqnLKSyuE7VXTSFBVxdu2lVVXUdH0shMGSlBWtpwZXgvOlK15U0NT1TbZZGlYLc6y80Pubm630FnwUzSj3kW3NfFOB-P03xXvNvpz2GtZs1KqJeDFMSCGLzPgpLcOLYyj8RBm1KxiolFcSZmk_CC1MSBG6O_bMKoXaHrQCzS9QNO01AlaMj3_c8B7y29KSfDqIID0TXsHUaN14C10LiYWugvu__nn_9jtEfot3AEOYY4-AdBMI9dU3yxrs2wNU5TyJeAnG5HBDQ</recordid><startdate>20151001</startdate><enddate>20151001</enddate><creator>Berlon, Nicholas R</creator><creator>Qi, Robert</creator><creator>Sharma-Kuinkel, Batu K</creator><creator>Joo, Hwang-Soo</creator><creator>Park, Lawrence P</creator><creator>George, Dennis</creator><creator>Thaden, Joshua T</creator><creator>Messina, Julia A</creator><creator>Maskarinec, Stacey A</creator><creator>Mueller-Premru, Manica</creator><creator>Athan, Eugene</creator><creator>Tattevin, Pierre</creator><creator>Pericas, Juan M</creator><creator>Woods, Christopher W</creator><creator>Otto, Michael</creator><creator>Fowler, Vance G</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-6445-7331</orcidid><orcidid>https://orcid.org/0000-0003-4668-3225</orcidid><orcidid>https://orcid.org/0000-0001-9838-6471</orcidid><orcidid>https://orcid.org/0000-0001-6419-7883</orcidid></search><sort><creationdate>20151001</creationdate><title>Clinical MRSA isolates from skin and soft tissue infections show increased in vitro production of phenol soluble modulins</title><author>Berlon, Nicholas R ; Qi, Robert ; Sharma-Kuinkel, Batu K ; Joo, Hwang-Soo ; Park, Lawrence P ; George, Dennis ; Thaden, Joshua T ; Messina, Julia A ; Maskarinec, Stacey A ; Mueller-Premru, Manica ; Athan, Eugene ; Tattevin, Pierre ; Pericas, Juan M ; Woods, Christopher W ; Otto, Michael ; Fowler, Vance G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c576t-6c33cf5994e5772bbb47d7039f4d3ae6e5c4b21a283215c8298e978cc3346a183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Bacterial Toxins - biosynthesis</topic><topic>Bacterial Toxins - chemistry</topic><topic>Community-Acquired Infections - microbiology</topic><topic>Endocarditis</topic><topic>Endocarditis, Bacterial - microbiology</topic><topic>Genotype</topic><topic>Humans</topic><topic>Infectious Disease</topic><topic>Methicillin-Resistant Staphylococcus aureus - genetics</topic><topic>Methicillin-Resistant Staphylococcus aureus - immunology</topic><topic>Methicillin-Resistant Staphylococcus aureus - isolation & purification</topic><topic>Methicillin-Resistant Staphylococcus aureus - metabolism</topic><topic>Microbial Sensitivity Tests</topic><topic>MRSA</topic><topic>Phenol soluble modulin</topic><topic>Phenols</topic><topic>Phenotype</topic><topic>Pneumonia</topic><topic>Pneumonia, Ventilator-Associated - microbiology</topic><topic>Skin - microbiology</topic><topic>Skin and soft tissue infection</topic><topic>Soft Tissue Infections - microbiology</topic><topic>Staphylococcal Skin Infections - metabolism</topic><topic>Staphylococcal Skin Infections - microbiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Berlon, Nicholas R</creatorcontrib><creatorcontrib>Qi, Robert</creatorcontrib><creatorcontrib>Sharma-Kuinkel, Batu K</creatorcontrib><creatorcontrib>Joo, Hwang-Soo</creatorcontrib><creatorcontrib>Park, Lawrence P</creatorcontrib><creatorcontrib>George, Dennis</creatorcontrib><creatorcontrib>Thaden, Joshua T</creatorcontrib><creatorcontrib>Messina, Julia A</creatorcontrib><creatorcontrib>Maskarinec, Stacey A</creatorcontrib><creatorcontrib>Mueller-Premru, Manica</creatorcontrib><creatorcontrib>Athan, Eugene</creatorcontrib><creatorcontrib>Tattevin, Pierre</creatorcontrib><creatorcontrib>Pericas, Juan M</creatorcontrib><creatorcontrib>Woods, Christopher W</creatorcontrib><creatorcontrib>Otto, Michael</creatorcontrib><creatorcontrib>Fowler, Vance G</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of infection</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Berlon, Nicholas R</au><au>Qi, Robert</au><au>Sharma-Kuinkel, Batu K</au><au>Joo, Hwang-Soo</au><au>Park, Lawrence P</au><au>George, Dennis</au><au>Thaden, Joshua T</au><au>Messina, Julia A</au><au>Maskarinec, Stacey A</au><au>Mueller-Premru, Manica</au><au>Athan, Eugene</au><au>Tattevin, Pierre</au><au>Pericas, Juan M</au><au>Woods, Christopher W</au><au>Otto, Michael</au><au>Fowler, Vance G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical MRSA isolates from skin and soft tissue infections show increased in vitro production of phenol soluble modulins</atitle><jtitle>The Journal of infection</jtitle><addtitle>J Infect</addtitle><date>2015-10-01</date><risdate>2015</risdate><volume>71</volume><issue>4</issue><spage>447</spage><epage>457</epage><pages>447-457</pages><issn>0163-4453</issn><eissn>1532-2742</eissn><abstract>Summary Background Phenol-soluble modulins (PSMs) are amphipathic, pro-inflammatory proteins secreted by most Staphylococcus aureus isolates. This study tested the hypothesis that in vitro PSM production levels are associated with specific clinical phenotypes. Methods 177 methicillin-resistant S. aureus (MRSA) isolates from infective endocarditis (IE), skin and soft tissue infection (SSTI), and hospital-acquired/ventilator-associated pneumonia (HAP) were matched by geographic origin, then genotyped using spa -typing. In vitro PSM production was measured by high performance liquid chromatography/mass spectrometry. Statistical analysis was performed using Chi-squared or Kruskal–Wallis tests as appropriate. Results Spa type 1 was significantly more common in SSTI isolates (62.7% SSTI; 1.7% IE; 16.9% HAP; p < 0.0001) while HAP and IE isolates were more commonly spa type 2 (0% SSTI; 37.3% IE; 40.7% HAP; p < 0.0001). USA300 isolates produced the highest levels of PSMs in vitro . SSTI isolates produced significantly higher quantities of PSMα1-4, PSMβ1, and δ-toxin than other isolates (p < 0.001). These findings persisted when USA300 isolates were excluded from analysis. Conclusions Increased in vitro production of PSMs is associated with an SSTI clinical source. This significant association persisted after exclusion of USA300 genotype isolates from analysis, suggesting that PSMs play a particularly important role in the pathogenesis of SSTI as compared to other infection types.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>26079275</pmid><doi>10.1016/j.jinf.2015.06.005</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0001-6445-7331</orcidid><orcidid>https://orcid.org/0000-0003-4668-3225</orcidid><orcidid>https://orcid.org/0000-0001-9838-6471</orcidid><orcidid>https://orcid.org/0000-0001-6419-7883</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Anti-Bacterial Agents - pharmacology Bacterial Toxins - biosynthesis Bacterial Toxins - chemistry Community-Acquired Infections - microbiology Endocarditis Endocarditis, Bacterial - microbiology Genotype Humans Infectious Disease Methicillin-Resistant Staphylococcus aureus - genetics Methicillin-Resistant Staphylococcus aureus - immunology Methicillin-Resistant Staphylococcus aureus - isolation & purification Methicillin-Resistant Staphylococcus aureus - metabolism Microbial Sensitivity Tests MRSA Phenol soluble modulin Phenols Phenotype Pneumonia Pneumonia, Ventilator-Associated - microbiology Skin - microbiology Skin and soft tissue infection Soft Tissue Infections - microbiology Staphylococcal Skin Infections - metabolism Staphylococcal Skin Infections - microbiology |
| title | Clinical MRSA isolates from skin and soft tissue infections show increased in vitro production of phenol soluble modulins |
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