Anticancer bioactive peptides suppress human colorectal tumor cell growth and induce apoptosis via modulating the PARP-p53-Mcl-1 signaling pathway

Aim: We have reported novel anticancer bioactive peptides (ACBPs) that show tumor-suppressive activities in human gastric cancer, leukemia, nasopharyngeal cancer, and gallbladder cancer. In this study, we investigated the effects of ACBPs on human colorectal cancer and the underlying mechanisms. Met...

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Veröffentlicht in:	Acta pharmacologica Sinica 2015-12, Vol.36 (12), p.1514-1519
Hauptverfasser:	Su, Li-ya, Shi, Ying-xu, Yan, Mei-rong, Xi, Yaguang, Su, Xiu-lan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - therapeutic use Apoptosis - drug effects Biomedical and Life Sciences Biomedicine Cell Proliferation - drug effects Colon - drug effects Colon - metabolism Colon - pathology Colorectal Neoplasms - drug therapy Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology HCT116 Cells Humans Immunology Internal Medicine Male Medical Microbiology Mice, Nude Myeloid Cell Leukemia Sequence 1 Protein - metabolism Original original-article Peptides - therapeutic use Pharmacology/Toxicology Poly(ADP-ribose) Polymerases - metabolism Rectum - drug effects Rectum - metabolism Rectum - pathology Signal Transduction - drug effects Tumor Suppressor Protein p53 - metabolism Vaccine
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