Syndrome of inappropriate antidiuretic hormone in a patient with leptomeningeal carcinomatosis
Leptomeningeal carcinomatosis is a condition in which metastatic cancer cells infiltrate the meninges of the brain and spinal cord, progressing to also involve the cerebrospinal fluid. Incidence of leptomeningeal carcinomatosis arising from an esophageal cancer is particularly rare. Here, we present...
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| Veröffentlicht in: | Journal of medical case reports 2016-03, Vol.10 (73), p.73-73, Article 73 |
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| creator | Boursiquot, Roosevelt Krol, Danielle Hanif, Sameul Rojas, Javier Jain, Maneesh |
| description | Leptomeningeal carcinomatosis is a condition in which metastatic cancer cells infiltrate the meninges of the brain and spinal cord, progressing to also involve the cerebrospinal fluid. Incidence of leptomeningeal carcinomatosis arising from an esophageal cancer is particularly rare.
Here, we present a case report of a 76-year-old Caucasian man with a history of esophageal adenocarcinoma status-post chemoradiation followed by resection. He was admitted to our unit for intractable headache, nausea without emesis, anorexia, weakness, gait instability, delirium, syncope, and near syncope. Our diagnostic workup revealed leptomeningeal carcinomatosis and syndrome of inappropriate antidiuretic hormone. Our patient was treated with lumbar puncture for the headache, methotrexate for the leptomeningeal carcinomatosis, and table salt for the syndrome of inappropriate antidiuretic hormone. Despite our best efforts, our patient died 6 weeks posttreatment.
Understanding the molecular pathogenesis of the development of syndrome of inappropriate antidiuretic hormone associated with leptomeningeal carcinomatosis from metastatic esophageal adenocarcinoma would help us to identify patients at risk and treat them accordingly. |
| doi_str_mv | 10.1186/s13256-016-0862-2 |
| format | Article |
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Here, we present a case report of a 76-year-old Caucasian man with a history of esophageal adenocarcinoma status-post chemoradiation followed by resection. He was admitted to our unit for intractable headache, nausea without emesis, anorexia, weakness, gait instability, delirium, syncope, and near syncope. Our diagnostic workup revealed leptomeningeal carcinomatosis and syndrome of inappropriate antidiuretic hormone. Our patient was treated with lumbar puncture for the headache, methotrexate for the leptomeningeal carcinomatosis, and table salt for the syndrome of inappropriate antidiuretic hormone. Despite our best efforts, our patient died 6 weeks posttreatment.
Understanding the molecular pathogenesis of the development of syndrome of inappropriate antidiuretic hormone associated with leptomeningeal carcinomatosis from metastatic esophageal adenocarcinoma would help us to identify patients at risk and treat them accordingly.</description><identifier>ISSN: 1752-1947</identifier><identifier>EISSN: 1752-1947</identifier><identifier>DOI: 10.1186/s13256-016-0862-2</identifier><identifier>PMID: 27036107</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Adenocarcinoma - secondary ; Aged ; Antimetabolites, Antineoplastic - therapeutic use ; Arachnoid cysts ; Care and treatment ; Case Report ; Case studies ; Consent ; Delirium ; Diagnosis ; Electroencephalography ; Esophageal cancer ; Esophageal Neoplasms ; Fatal Outcome ; Headache Disorders - therapy ; Headaches ; Hearing loss ; Humans ; Hypertension ; Inappropriate ADH Syndrome - etiology ; Inappropriate ADH Syndrome - therapy ; Male ; Medical imaging ; Medical prognosis ; Meningeal Carcinomatosis - diet therapy ; Meningeal Carcinomatosis - secondary ; Meningitis ; Metastasis ; Methotrexate - therapeutic use ; NMR ; Nuclear magnetic resonance ; Sodium ; Sodium Chloride, Dietary - therapeutic use ; Spinal Puncture ; Tumors ; Urine</subject><ispartof>Journal of medical case reports, 2016-03, Vol.10 (73), p.73-73, Article 73</ispartof><rights>COPYRIGHT 2016 BioMed Central Ltd.</rights><rights>Copyright BioMed Central 2016</rights><rights>Boursiquot et al. 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4402-8db9b881f9851f1bdb748ad0a70a2240efa0a0c62f555161fa16dd03e9d58a5a3</citedby><cites>FETCH-LOGICAL-c4402-8db9b881f9851f1bdb748ad0a70a2240efa0a0c62f555161fa16dd03e9d58a5a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4815213/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4815213/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27036107$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Boursiquot, Roosevelt</creatorcontrib><creatorcontrib>Krol, Danielle</creatorcontrib><creatorcontrib>Hanif, Sameul</creatorcontrib><creatorcontrib>Rojas, Javier</creatorcontrib><creatorcontrib>Jain, Maneesh</creatorcontrib><title>Syndrome of inappropriate antidiuretic hormone in a patient with leptomeningeal carcinomatosis</title><title>Journal of medical case reports</title><addtitle>J Med Case Rep</addtitle><description>Leptomeningeal carcinomatosis is a condition in which metastatic cancer cells infiltrate the meninges of the brain and spinal cord, progressing to also involve the cerebrospinal fluid. Incidence of leptomeningeal carcinomatosis arising from an esophageal cancer is particularly rare.
Here, we present a case report of a 76-year-old Caucasian man with a history of esophageal adenocarcinoma status-post chemoradiation followed by resection. He was admitted to our unit for intractable headache, nausea without emesis, anorexia, weakness, gait instability, delirium, syncope, and near syncope. Our diagnostic workup revealed leptomeningeal carcinomatosis and syndrome of inappropriate antidiuretic hormone. Our patient was treated with lumbar puncture for the headache, methotrexate for the leptomeningeal carcinomatosis, and table salt for the syndrome of inappropriate antidiuretic hormone. Despite our best efforts, our patient died 6 weeks posttreatment.
Understanding the molecular pathogenesis of the development of syndrome of inappropriate antidiuretic hormone associated with leptomeningeal carcinomatosis from metastatic esophageal adenocarcinoma would help us to identify patients at risk and treat them accordingly.</description><subject>Adenocarcinoma - secondary</subject><subject>Aged</subject><subject>Antimetabolites, Antineoplastic - therapeutic use</subject><subject>Arachnoid cysts</subject><subject>Care and treatment</subject><subject>Case Report</subject><subject>Case studies</subject><subject>Consent</subject><subject>Delirium</subject><subject>Diagnosis</subject><subject>Electroencephalography</subject><subject>Esophageal cancer</subject><subject>Esophageal Neoplasms</subject><subject>Fatal Outcome</subject><subject>Headache Disorders - therapy</subject><subject>Headaches</subject><subject>Hearing loss</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Inappropriate ADH Syndrome - etiology</subject><subject>Inappropriate ADH Syndrome - therapy</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Medical prognosis</subject><subject>Meningeal Carcinomatosis - diet therapy</subject><subject>Meningeal Carcinomatosis - secondary</subject><subject>Meningitis</subject><subject>Metastasis</subject><subject>Methotrexate - therapeutic use</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Sodium</subject><subject>Sodium Chloride, Dietary - therapeutic use</subject><subject>Spinal Puncture</subject><subject>Tumors</subject><subject>Urine</subject><issn>1752-1947</issn><issn>1752-1947</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNptkl1rFTEQhhdRbK3-AG9kQZDebM1kN5vsjVCKVaHghXprmM3HOSm7yZpklf57czi1niMyhITkeWcyw1tVL4FcAIj-bYKWsr4hUJboaUMfVafAGW1g6Pjjg_NJ9SylW0JYL4b2aXVCOWl7IPy0-v7lzusYZlMHWzuPyxLDEh1mU6PPTrs1muxUvQ1xDt4UpMZ6weyMz_Uvl7f1ZJZc9N75jcGpVhiV82HGHJJLz6snFqdkXtzvZ9W36_dfrz42N58_fLq6vGlU1xHaCD0OoxBgB8HAwqhH3gnUBDlBSjtiLBIkqqeWMQY9WIRea9KaQTOBDNuz6t0-77KOs9Gq_C7iJEsnM8Y7GdDJ4xfvtnITfspOAKPQlgTn9wli-LGalOXskjLThN6ENUngXHAgJQr6-h_0NqzRl_YKNbCBk6Ejf6kNTkY6b0Opq3ZJ5WXHSkVOW1qoi_9QJbSZnSoDt67cHwneHAi2ZeJ5m8K0Zhd8OgZhD6oYUorGPgwDiNy5R-7dI4t75M49cqd5dTjFB8Ufu7S_Af3_v8U</recordid><startdate>20160331</startdate><enddate>20160331</enddate><creator>Boursiquot, Roosevelt</creator><creator>Krol, Danielle</creator><creator>Hanif, Sameul</creator><creator>Rojas, Javier</creator><creator>Jain, Maneesh</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160331</creationdate><title>Syndrome of inappropriate antidiuretic hormone in a patient with leptomeningeal carcinomatosis</title><author>Boursiquot, Roosevelt ; Krol, Danielle ; Hanif, Sameul ; Rojas, Javier ; Jain, Maneesh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4402-8db9b881f9851f1bdb748ad0a70a2240efa0a0c62f555161fa16dd03e9d58a5a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adenocarcinoma - secondary</topic><topic>Aged</topic><topic>Antimetabolites, Antineoplastic - therapeutic use</topic><topic>Arachnoid cysts</topic><topic>Care and treatment</topic><topic>Case Report</topic><topic>Case studies</topic><topic>Consent</topic><topic>Delirium</topic><topic>Diagnosis</topic><topic>Electroencephalography</topic><topic>Esophageal cancer</topic><topic>Esophageal Neoplasms</topic><topic>Fatal Outcome</topic><topic>Headache Disorders - therapy</topic><topic>Headaches</topic><topic>Hearing loss</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Inappropriate ADH Syndrome - etiology</topic><topic>Inappropriate ADH Syndrome - therapy</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Medical prognosis</topic><topic>Meningeal Carcinomatosis - diet therapy</topic><topic>Meningeal Carcinomatosis - secondary</topic><topic>Meningitis</topic><topic>Metastasis</topic><topic>Methotrexate - therapeutic use</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Sodium</topic><topic>Sodium Chloride, Dietary - therapeutic use</topic><topic>Spinal Puncture</topic><topic>Tumors</topic><topic>Urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Boursiquot, Roosevelt</creatorcontrib><creatorcontrib>Krol, Danielle</creatorcontrib><creatorcontrib>Hanif, Sameul</creatorcontrib><creatorcontrib>Rojas, Javier</creatorcontrib><creatorcontrib>Jain, Maneesh</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of medical case reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Boursiquot, Roosevelt</au><au>Krol, Danielle</au><au>Hanif, Sameul</au><au>Rojas, Javier</au><au>Jain, Maneesh</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Syndrome of inappropriate antidiuretic hormone in a patient with leptomeningeal carcinomatosis</atitle><jtitle>Journal of medical case reports</jtitle><addtitle>J Med Case Rep</addtitle><date>2016-03-31</date><risdate>2016</risdate><volume>10</volume><issue>73</issue><spage>73</spage><epage>73</epage><pages>73-73</pages><artnum>73</artnum><issn>1752-1947</issn><eissn>1752-1947</eissn><abstract>Leptomeningeal carcinomatosis is a condition in which metastatic cancer cells infiltrate the meninges of the brain and spinal cord, progressing to also involve the cerebrospinal fluid. Incidence of leptomeningeal carcinomatosis arising from an esophageal cancer is particularly rare.
Here, we present a case report of a 76-year-old Caucasian man with a history of esophageal adenocarcinoma status-post chemoradiation followed by resection. He was admitted to our unit for intractable headache, nausea without emesis, anorexia, weakness, gait instability, delirium, syncope, and near syncope. Our diagnostic workup revealed leptomeningeal carcinomatosis and syndrome of inappropriate antidiuretic hormone. Our patient was treated with lumbar puncture for the headache, methotrexate for the leptomeningeal carcinomatosis, and table salt for the syndrome of inappropriate antidiuretic hormone. Despite our best efforts, our patient died 6 weeks posttreatment.
Understanding the molecular pathogenesis of the development of syndrome of inappropriate antidiuretic hormone associated with leptomeningeal carcinomatosis from metastatic esophageal adenocarcinoma would help us to identify patients at risk and treat them accordingly.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>27036107</pmid><doi>10.1186/s13256-016-0862-2</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; PubMed Central Open Access; Springer Nature OA Free Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; SpringerLink Journals - AutoHoldings |
| subjects | Adenocarcinoma - secondary Aged Antimetabolites, Antineoplastic - therapeutic use Arachnoid cysts Care and treatment Case Report Case studies Consent Delirium Diagnosis Electroencephalography Esophageal cancer Esophageal Neoplasms Fatal Outcome Headache Disorders - therapy Headaches Hearing loss Humans Hypertension Inappropriate ADH Syndrome - etiology Inappropriate ADH Syndrome - therapy Male Medical imaging Medical prognosis Meningeal Carcinomatosis - diet therapy Meningeal Carcinomatosis - secondary Meningitis Metastasis Methotrexate - therapeutic use NMR Nuclear magnetic resonance Sodium Sodium Chloride, Dietary - therapeutic use Spinal Puncture Tumors Urine |
| title | Syndrome of inappropriate antidiuretic hormone in a patient with leptomeningeal carcinomatosis |
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