Morphine Suppository versus Indomethacin Suppository in the Management of Renal Colic: Randomized Clinical Trial
Background. Renal colic is a medical emergency due to the rapid onset and devastating nature of its pain. Opioids and nonsteroidal anti-inflammatory drugs (NSAIDs) are both used as first-line choices in its management. Aim. This study aimed to compare the efficacy and safety of opioids and NSAIDs in...
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| Veröffentlicht in: | Pain Research and Treatment 2016-01, Vol.2016, p.82-87 |
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| creator | Zamanian, Forough Jalili, Mohammad Moradi-Lakeh, Maziar Kia, Maryam Aghili, Rokhsareh Aghili, Seyed Mojtaba |
| description | Background. Renal colic is a medical emergency due to the rapid onset and devastating nature of its pain. Opioids and nonsteroidal anti-inflammatory drugs (NSAIDs) are both used as first-line choices in its management. Aim. This study aimed to compare the efficacy and safety of opioids and NSAIDs in the management of acute renal colic. Methods. One hundred and fifty-eight patients were divided into two groups (n=79) and received either 10 mg morphine or 100 mg indomethacin suppositories. The severity of pain was measured using verbal numeric rating scale at baseline and 20, 40, 60, and 90 minutes after the administration of analgesics. Drug side effects as well as patients’ vital signs were also recorded. Results. The mean decrease in the pain score during the first 20 minutes was significantly higher among those who received morphine suppository. However, no significant difference was observed between the two groups regarding the mean decrease in pain score during the first 40, 60, and 90 minutes after the admission. Prevalence of drug side effects or changes in the vital signs was not significantly different between the two groups. Conclusions. Morphine suppositories seem to be more efficient in achieving rapid pain relief comparing to indomethacin. |
| doi_str_mv | 10.1155/2016/4981585 |
| format | Article |
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Renal colic is a medical emergency due to the rapid onset and devastating nature of its pain. Opioids and nonsteroidal anti-inflammatory drugs (NSAIDs) are both used as first-line choices in its management. Aim. This study aimed to compare the efficacy and safety of opioids and NSAIDs in the management of acute renal colic. Methods. One hundred and fifty-eight patients were divided into two groups (n=79) and received either 10 mg morphine or 100 mg indomethacin suppositories. The severity of pain was measured using verbal numeric rating scale at baseline and 20, 40, 60, and 90 minutes after the administration of analgesics. Drug side effects as well as patients’ vital signs were also recorded. Results. The mean decrease in the pain score during the first 20 minutes was significantly higher among those who received morphine suppository. However, no significant difference was observed between the two groups regarding the mean decrease in pain score during the first 40, 60, and 90 minutes after the admission. Prevalence of drug side effects or changes in the vital signs was not significantly different between the two groups. Conclusions. Morphine suppositories seem to be more efficient in achieving rapid pain relief comparing to indomethacin.</description><identifier>ISSN: 2090-1542</identifier><identifier>EISSN: 2090-1550</identifier><identifier>DOI: 10.1155/2016/4981585</identifier><identifier>PMID: 27073696</identifier><language>eng</language><publisher>United States: Hindawi Limiteds</publisher><subject>Anti-inflammatory drugs ; Care and treatment ; Clinical trials ; Colic ; Dosage and administration ; Kidney diseases ; Kidneys ; Narcotics ; Nonsteroidal anti-inflammatory drugs ; Pain ; Pain management ; Patient outcomes</subject><ispartof>Pain Research and Treatment, 2016-01, Vol.2016, p.82-87</ispartof><rights>Copyright © 2016 Forough Zamanian et al.</rights><rights>COPYRIGHT 2016 John Wiley & Sons, Inc.</rights><rights>Copyright © 2016 Forough Zamanian et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2016 Forough Zamanian et al. 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a582t-8f5acfb522dfdaf96808082ff7f695ccad5e3a234188a28e44bd7d66838697c33</citedby><cites>FETCH-LOGICAL-a582t-8f5acfb522dfdaf96808082ff7f695ccad5e3a234188a28e44bd7d66838697c33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814695/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814695/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27073696$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Varrassi, Giustino</contributor><creatorcontrib>Zamanian, Forough</creatorcontrib><creatorcontrib>Jalili, Mohammad</creatorcontrib><creatorcontrib>Moradi-Lakeh, Maziar</creatorcontrib><creatorcontrib>Kia, Maryam</creatorcontrib><creatorcontrib>Aghili, Rokhsareh</creatorcontrib><creatorcontrib>Aghili, Seyed Mojtaba</creatorcontrib><title>Morphine Suppository versus Indomethacin Suppository in the Management of Renal Colic: Randomized Clinical Trial</title><title>Pain Research and Treatment</title><addtitle>Pain Res Treat</addtitle><description>Background. Renal colic is a medical emergency due to the rapid onset and devastating nature of its pain. Opioids and nonsteroidal anti-inflammatory drugs (NSAIDs) are both used as first-line choices in its management. Aim. This study aimed to compare the efficacy and safety of opioids and NSAIDs in the management of acute renal colic. Methods. One hundred and fifty-eight patients were divided into two groups (n=79) and received either 10 mg morphine or 100 mg indomethacin suppositories. The severity of pain was measured using verbal numeric rating scale at baseline and 20, 40, 60, and 90 minutes after the administration of analgesics. Drug side effects as well as patients’ vital signs were also recorded. Results. The mean decrease in the pain score during the first 20 minutes was significantly higher among those who received morphine suppository. However, no significant difference was observed between the two groups regarding the mean decrease in pain score during the first 40, 60, and 90 minutes after the admission. Prevalence of drug side effects or changes in the vital signs was not significantly different between the two groups. Conclusions. Morphine suppositories seem to be more efficient in achieving rapid pain relief comparing to indomethacin.</description><subject>Anti-inflammatory drugs</subject><subject>Care and treatment</subject><subject>Clinical trials</subject><subject>Colic</subject><subject>Dosage and administration</subject><subject>Kidney diseases</subject><subject>Kidneys</subject><subject>Narcotics</subject><subject>Nonsteroidal anti-inflammatory drugs</subject><subject>Pain</subject><subject>Pain management</subject><subject>Patient outcomes</subject><issn>2090-1542</issn><issn>2090-1550</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkttrFDEUxgdRbKl981kGfBF02yQzuYwPQlm8VFqUWp9DNpfdlJlkmsxU6l_vGWbduiI4Ycjl_M6X5OQriucYnWBM6SlBmJ3WjcBU0EfFIUENWsA6erwb1-SgOM75BsFHUU05elocEI54xRp2WPSXMfUbH2z5bez7mP0Q0315Z1Mec3keTOzssFHah704TIeNLS9VUGvb2TCU0ZVXNqi2XMbW67fllZpy_U9rymXrg9cQuk5etc-KJ0612R5v-6Pi-4f318tPi4svH8-XZxcLRQUZFsJRpd2KEmKcUa5hAkEjznHHGqq1MtRWilQ1FkIRYet6ZbhhTFSCNVxX1VHxbtbtx1VnjYZDJtXKPvlOpXsZlZf7keA3ch3vZC1wDVuAwKutQIq3o82D7HzWtm1VsHHMEnMBTwCVrAF9-Rd6E8cE1ZgozhBDFWoeqLVqrfTBRdhXT6LyjCJCEReEAXXyDwqasZ3XMVjnYX0v4c2coFPMOVm3uyNGcjKJnEwityYB_MWfddnBvy0BwOsZAFcY9cP_T-7zTCuf_OAfLv51whCFH80pmEwdR1A1hDDdnwgiBa9-AbIC18w</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>Zamanian, Forough</creator><creator>Jalili, Mohammad</creator><creator>Moradi-Lakeh, Maziar</creator><creator>Kia, Maryam</creator><creator>Aghili, Rokhsareh</creator><creator>Aghili, Seyed Mojtaba</creator><general>Hindawi Limiteds</general><general>Hindawi Publishing Corporation</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>188</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7XB</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PADUT</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160101</creationdate><title>Morphine Suppository versus Indomethacin Suppository in the Management of Renal Colic: Randomized Clinical Trial</title><author>Zamanian, Forough ; Jalili, Mohammad ; Moradi-Lakeh, Maziar ; Kia, Maryam ; Aghili, Rokhsareh ; Aghili, Seyed Mojtaba</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a582t-8f5acfb522dfdaf96808082ff7f695ccad5e3a234188a28e44bd7d66838697c33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Anti-inflammatory drugs</topic><topic>Care and treatment</topic><topic>Clinical trials</topic><topic>Colic</topic><topic>Dosage and administration</topic><topic>Kidney diseases</topic><topic>Kidneys</topic><topic>Narcotics</topic><topic>Nonsteroidal anti-inflammatory drugs</topic><topic>Pain</topic><topic>Pain management</topic><topic>Patient outcomes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zamanian, Forough</creatorcontrib><creatorcontrib>Jalili, Mohammad</creatorcontrib><creatorcontrib>Moradi-Lakeh, Maziar</creatorcontrib><creatorcontrib>Kia, Maryam</creatorcontrib><creatorcontrib>Aghili, Rokhsareh</creatorcontrib><creatorcontrib>Aghili, Seyed Mojtaba</creatorcontrib><collection>Airiti Library</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Research Library China</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Pain Research and Treatment</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zamanian, Forough</au><au>Jalili, Mohammad</au><au>Moradi-Lakeh, Maziar</au><au>Kia, Maryam</au><au>Aghili, Rokhsareh</au><au>Aghili, Seyed Mojtaba</au><au>Varrassi, Giustino</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Morphine Suppository versus Indomethacin Suppository in the Management of Renal Colic: Randomized Clinical Trial</atitle><jtitle>Pain Research and Treatment</jtitle><addtitle>Pain Res Treat</addtitle><date>2016-01-01</date><risdate>2016</risdate><volume>2016</volume><spage>82</spage><epage>87</epage><pages>82-87</pages><issn>2090-1542</issn><eissn>2090-1550</eissn><abstract>Background. Renal colic is a medical emergency due to the rapid onset and devastating nature of its pain. Opioids and nonsteroidal anti-inflammatory drugs (NSAIDs) are both used as first-line choices in its management. Aim. This study aimed to compare the efficacy and safety of opioids and NSAIDs in the management of acute renal colic. Methods. One hundred and fifty-eight patients were divided into two groups (n=79) and received either 10 mg morphine or 100 mg indomethacin suppositories. The severity of pain was measured using verbal numeric rating scale at baseline and 20, 40, 60, and 90 minutes after the administration of analgesics. Drug side effects as well as patients’ vital signs were also recorded. Results. The mean decrease in the pain score during the first 20 minutes was significantly higher among those who received morphine suppository. However, no significant difference was observed between the two groups regarding the mean decrease in pain score during the first 40, 60, and 90 minutes after the admission. Prevalence of drug side effects or changes in the vital signs was not significantly different between the two groups. Conclusions. Morphine suppositories seem to be more efficient in achieving rapid pain relief comparing to indomethacin.</abstract><cop>United States</cop><pub>Hindawi Limiteds</pub><pmid>27073696</pmid><doi>10.1155/2016/4981585</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Anti-inflammatory drugs Care and treatment Clinical trials Colic Dosage and administration Kidney diseases Kidneys Narcotics Nonsteroidal anti-inflammatory drugs Pain Pain management Patient outcomes |
| title | Morphine Suppository versus Indomethacin Suppository in the Management of Renal Colic: Randomized Clinical Trial |
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