Rapid Increases in proBDNF after Pilocarpine-Induced Status Epilepticus in Mice Are Associated with Reduced proBDNF Cleavage Machinery

Brain-derived neurotrophic factor (BDNF) levels are elevated after status epilepticus (SE), leading to activation of multiple signaling pathways, including the janus kinase/signal transducer and activator of transcription pathway that mediates a decrease in GABAA receptor α1 subunits in the hippocam...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	eNeuro 2016-01, Vol.3 (1), p.ENEURO.0020-15.2016
Hauptverfasser:	Thomas, Ajay X, Cruz Del Angel, Yasmin, Gonzalez, Marco I, Carrel, Andrew J, Carlsen, Jessica, Lam, Philip M, Hempstead, Barbara L, Russek, Shelley J, Brooks-Kayal, Amy R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Astrocytes - metabolism Brain-Derived Neurotrophic Factor - metabolism Hippocampus - metabolism Male Mice Mice, Inbred C57BL Neurons - metabolism New Research Pilocarpine Plasminogen Activator Inhibitor 1 - metabolism Protein Precursors - metabolism Protein Processing, Post-Translational Status Epilepticus - chemically induced Status Epilepticus - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!