DCLAK11, a multi-tyrosine kinase inhibitor, exhibits potent antitumor and antiangiogenic activity in vitro

Aim： To investigate the molecular targets of DCLAK11, a novel compound discovered from a series of substituted pyridin-3-amine derivatives, and to characterize its anti-tumor properties in vitro. Methods： Kinase inhibition was measured by an ELISA assay. Cell viability was assessed with an SRB or a...

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Veröffentlicht in:	Acta pharmacologica Sinica 2015-10, Vol.36 (10), p.1266-1276
Hauptverfasser:	Guo, Xiao-bin, Chen, Xian-jie, Tong, Lin-jiang, Peng, Xia, Huang, Min, Liu, Hong-chun, Liu, Hong, Ding, Jian
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Inhibitors - chemistry Angiogenesis Inhibitors - pharmacology Animals Apoptosis - drug effects Biomedical and Life Sciences Biomedicine Cell Line, Tumor Cell Proliferation - drug effects Human Umbilical Vein Endothelial Cells Humans Immunology Internal Medicine Male Medical Microbiology Neoplasms - drug therapy Neoplasms - metabolism Neoplasms - pathology Neovascularization, Pathologic - drug therapy Neovascularization, Pathologic - metabolism Neovascularization, Pathologic - pathology Original original-article Pharmacology/Toxicology Protein Kinase Inhibitors - chemistry Protein Kinase Inhibitors - pharmacology Pyridines - chemistry Pyridines - pharmacology Rats, Sprague-Dawley Receptor, Epidermal Growth Factor - antagonists & inhibitors Receptor, Epidermal Growth Factor - metabolism Receptor, ErbB-2 - antagonists & inhibitors Receptor, ErbB-2 - metabolism Signal Transduction - drug effects Vaccine Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors Vascular Endothelial Growth Factor Receptor-2 - metabolism 体外实验体外抗肿瘤化合物抗血管生成衍生物酪氨酸激酶抑制剂
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