Pathogenesis and Transmission of Swine-Origin 2009 A(H1N1) Influenza Virus in Ferrets
The swine-origin A(H1N1) influenza virus that has emerged in humans in early 2009 has raised concerns about pandemic developments. In a ferret pathogenesis and transmission model, the 2009 A(H1N1) influenza virus was found to be more pathogenic than a seasonal A(H1N1) virus, with more extensive viru...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2009-07, Vol.325 (5939), p.481-483 |
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| creator | Munster, Vincent J de Wit, Emmie van den Brand, Judith M.A Herfst, Sander Schrauwen, Eefje J.A Bestebroer, Theo M van de Vijver, David Boucher, Charles A Koopmans, Marion Rimmelzwaan, Guus F Kuiken, Thijs Osterhaus, Albert D.M.E Fouchier, Ron A.M |
| description | The swine-origin A(H1N1) influenza virus that has emerged in humans in early 2009 has raised concerns about pandemic developments. In a ferret pathogenesis and transmission model, the 2009 A(H1N1) influenza virus was found to be more pathogenic than a seasonal A(H1N1) virus, with more extensive virus replication occurring in the respiratory tract. Replication of seasonal A(H1N1) virus was confined to the nasal cavity of ferrets, but the 2009 A(H1N1) influenza virus also replicated in the trachea, bronchi, and bronchioles. Virus shedding was more abundant from the upper respiratory tract for 2009 A(H1N1) influenza virus as compared with seasonal virus, and transmission via aerosol or respiratory droplets was equally efficient. These data suggest that the 2009 A(H1N1) influenza virus has the ability to persist in the human population, potentially with more severe clinical consequences. |
| doi_str_mv | 10.1126/science.1177127 |
| format | Article |
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In a ferret pathogenesis and transmission model, the 2009 A(H1N1) influenza virus was found to be more pathogenic than a seasonal A(H1N1) virus, with more extensive virus replication occurring in the respiratory tract. Replication of seasonal A(H1N1) virus was confined to the nasal cavity of ferrets, but the 2009 A(H1N1) influenza virus also replicated in the trachea, bronchi, and bronchioles. Virus shedding was more abundant from the upper respiratory tract for 2009 A(H1N1) influenza virus as compared with seasonal virus, and transmission via aerosol or respiratory droplets was equally efficient. These data suggest that the 2009 A(H1N1) influenza virus has the ability to persist in the human population, potentially with more severe clinical consequences.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.1177127</identifier><identifier>PMID: 19574348</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Association for the Advancement of Science</publisher><subject>Aerosols ; Animal diseases ; Animals ; Biological and medical sciences ; Bronchi - virology ; Child, Preschool ; Disease Models, Animal ; Disease transmission ; Female ; Ferrets ; Human viral diseases ; Humans ; Infections ; Infectious diseases ; Influenza A Virus, H1N1 Subtype - pathogenicity ; Influenza virus ; Influenza, Human - pathology ; Influenza, Human - transmission ; Influenza, Human - virology ; Inoculation ; Lungs ; Mammals ; Medical sciences ; Mustela ; Orthomyxoviridae ; Orthomyxoviridae Infections - pathology ; Orthomyxoviridae Infections - transmission ; Orthomyxoviridae Infections - virology ; Pathology ; Respiratory System - virology ; Seasons ; Swine - virology ; Swine flu ; Throat ; Trachea ; Trachea - virology ; Viral diseases ; Viral diseases of the respiratory system and ent viral diseases ; Virus Replication ; Virus Shedding ; Viruses</subject><ispartof>Science (American Association for the Advancement of Science), 2009-07, Vol.325 (5939), p.481-483</ispartof><rights>Copyright 2009 American Association for the Advancement of Science</rights><rights>2009 INIST-CNRS</rights><rights>Copyright © 2009, American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c652t-d0bc3e8a62a7e9b13c42a7d76b61b7175e24170febf9ffbd2d3d90c31835e8653</citedby><cites>FETCH-LOGICAL-c652t-d0bc3e8a62a7e9b13c42a7d76b61b7175e24170febf9ffbd2d3d90c31835e8653</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/20536711$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/20536711$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,776,780,799,881,2871,2872,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21790545$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19574348$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Munster, Vincent J</creatorcontrib><creatorcontrib>de Wit, Emmie</creatorcontrib><creatorcontrib>van den Brand, Judith M.A</creatorcontrib><creatorcontrib>Herfst, Sander</creatorcontrib><creatorcontrib>Schrauwen, Eefje J.A</creatorcontrib><creatorcontrib>Bestebroer, Theo M</creatorcontrib><creatorcontrib>van de Vijver, David</creatorcontrib><creatorcontrib>Boucher, Charles A</creatorcontrib><creatorcontrib>Koopmans, Marion</creatorcontrib><creatorcontrib>Rimmelzwaan, Guus F</creatorcontrib><creatorcontrib>Kuiken, Thijs</creatorcontrib><creatorcontrib>Osterhaus, Albert D.M.E</creatorcontrib><creatorcontrib>Fouchier, Ron A.M</creatorcontrib><title>Pathogenesis and Transmission of Swine-Origin 2009 A(H1N1) Influenza Virus in Ferrets</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>The swine-origin A(H1N1) influenza virus that has emerged in humans in early 2009 has raised concerns about pandemic developments. In a ferret pathogenesis and transmission model, the 2009 A(H1N1) influenza virus was found to be more pathogenic than a seasonal A(H1N1) virus, with more extensive virus replication occurring in the respiratory tract. Replication of seasonal A(H1N1) virus was confined to the nasal cavity of ferrets, but the 2009 A(H1N1) influenza virus also replicated in the trachea, bronchi, and bronchioles. Virus shedding was more abundant from the upper respiratory tract for 2009 A(H1N1) influenza virus as compared with seasonal virus, and transmission via aerosol or respiratory droplets was equally efficient. These data suggest that the 2009 A(H1N1) influenza virus has the ability to persist in the human population, potentially with more severe clinical consequences.</description><subject>Aerosols</subject><subject>Animal diseases</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Bronchi - virology</subject><subject>Child, Preschool</subject><subject>Disease Models, Animal</subject><subject>Disease transmission</subject><subject>Female</subject><subject>Ferrets</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Influenza A Virus, H1N1 Subtype - pathogenicity</subject><subject>Influenza virus</subject><subject>Influenza, Human - pathology</subject><subject>Influenza, Human - transmission</subject><subject>Influenza, Human - virology</subject><subject>Inoculation</subject><subject>Lungs</subject><subject>Mammals</subject><subject>Medical sciences</subject><subject>Mustela</subject><subject>Orthomyxoviridae</subject><subject>Orthomyxoviridae Infections - 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In a ferret pathogenesis and transmission model, the 2009 A(H1N1) influenza virus was found to be more pathogenic than a seasonal A(H1N1) virus, with more extensive virus replication occurring in the respiratory tract. Replication of seasonal A(H1N1) virus was confined to the nasal cavity of ferrets, but the 2009 A(H1N1) influenza virus also replicated in the trachea, bronchi, and bronchioles. Virus shedding was more abundant from the upper respiratory tract for 2009 A(H1N1) influenza virus as compared with seasonal virus, and transmission via aerosol or respiratory droplets was equally efficient. These data suggest that the 2009 A(H1N1) influenza virus has the ability to persist in the human population, potentially with more severe clinical consequences.</abstract><cop>Washington, DC</cop><pub>American Association for the Advancement of Science</pub><pmid>19574348</pmid><doi>10.1126/science.1177127</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 2009-07, Vol.325 (5939), p.481-483 |
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| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4814155 |
| source | Jstor Complete Legacy; MEDLINE; Science Magazine |
| subjects | Aerosols Animal diseases Animals Biological and medical sciences Bronchi - virology Child, Preschool Disease Models, Animal Disease transmission Female Ferrets Human viral diseases Humans Infections Infectious diseases Influenza A Virus, H1N1 Subtype - pathogenicity Influenza virus Influenza, Human - pathology Influenza, Human - transmission Influenza, Human - virology Inoculation Lungs Mammals Medical sciences Mustela Orthomyxoviridae Orthomyxoviridae Infections - pathology Orthomyxoviridae Infections - transmission Orthomyxoviridae Infections - virology Pathology Respiratory System - virology Seasons Swine - virology Swine flu Throat Trachea Trachea - virology Viral diseases Viral diseases of the respiratory system and ent viral diseases Virus Replication Virus Shedding Viruses |
| title | Pathogenesis and Transmission of Swine-Origin 2009 A(H1N1) Influenza Virus in Ferrets |
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