Atrial Fibrillation and Hypertension: Mechanistic, Epidemiologic, and Treatment Parallels
Atrial fibrillation (AF) is an increasingly prevalent condition and the most common sustained arrhythmia encountered in ambulatory and hospital practice. Several clinical risk factors for AF include age, sex, valvular heart disease, obesity, sleep apnea, heart failure, and hypertension (HTN). Of all...
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| Veröffentlicht in: | Methodist DeBakey cardiovascular journal 2015-10, Vol.11 (4), p.228-234 |
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| creator | Ogunsua, Adedotun A Shaikh, Amir Y Ahmed, Mohamed McManus, David D |
| description | Atrial fibrillation (AF) is an increasingly prevalent condition and the most common sustained arrhythmia encountered in ambulatory and hospital practice. Several clinical risk factors for AF include age, sex, valvular heart disease, obesity, sleep apnea, heart failure, and hypertension (HTN). Of all the risk factors, HTN is the most commonly encountered condition in patients with incident AF. Hypertension is associated with a 1.8-fold increase in the risk of developing new-onset AF and a 1.5-fold increase in the risk of progression to permanent AF. Hypertension predisposes to cardiac structural changes that influence the development of AF such as atrial remodeling. The renin angiotensin aldosterone system has been demonstrated to be a common mechanistic link in the pathogenesis of HTN and AF. Importantly, HTN is one of the few modifiable AF risk factors, and guideline-directed management of HTN may reduce the incidence of AF. |
| doi_str_mv | 10.14797/mdcj-11-4-228 |
| format | Article |
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Several clinical risk factors for AF include age, sex, valvular heart disease, obesity, sleep apnea, heart failure, and hypertension (HTN). Of all the risk factors, HTN is the most commonly encountered condition in patients with incident AF. Hypertension is associated with a 1.8-fold increase in the risk of developing new-onset AF and a 1.5-fold increase in the risk of progression to permanent AF. Hypertension predisposes to cardiac structural changes that influence the development of AF such as atrial remodeling. The renin angiotensin aldosterone system has been demonstrated to be a common mechanistic link in the pathogenesis of HTN and AF. Importantly, HTN is one of the few modifiable AF risk factors, and guideline-directed management of HTN may reduce the incidence of AF.</description><identifier>ISSN: 1947-6094</identifier><identifier>EISSN: 1947-6108</identifier><identifier>DOI: 10.14797/mdcj-11-4-228</identifier><identifier>PMID: 27057292</identifier><language>eng</language><publisher>United States: The Methodist Hospital Houston, Texas</publisher><subject>Atrial Fibrillation - diagnosis ; Atrial Fibrillation - epidemiology ; Atrial Fibrillation - physiopathology ; Atrial Fibrillation - prevention & control ; Comorbidity ; Humans ; Hypertension ; Hypertension - diagnosis ; Hypertension - epidemiology ; Hypertension - physiopathology ; Hypertension - therapy ; Incidence ; Prevalence ; Prognosis ; Risk Assessment ; Risk Factors</subject><ispartof>Methodist DeBakey cardiovascular journal, 2015-10, Vol.11 (4), p.228-234</ispartof><rights>2015 Houston Methodist Hospital Houston, Texas 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3058-4644c88ec819160873a8f81aef18d11d7bf24262218c70ac24e105ab6b1ed1003</citedby><cites>FETCH-LOGICAL-c3058-4644c88ec819160873a8f81aef18d11d7bf24262218c70ac24e105ab6b1ed1003</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814009/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814009/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27057292$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ogunsua, Adedotun A</creatorcontrib><creatorcontrib>Shaikh, Amir Y</creatorcontrib><creatorcontrib>Ahmed, Mohamed</creatorcontrib><creatorcontrib>McManus, David D</creatorcontrib><title>Atrial Fibrillation and Hypertension: Mechanistic, Epidemiologic, and Treatment Parallels</title><title>Methodist DeBakey cardiovascular journal</title><addtitle>Methodist Debakey Cardiovasc J</addtitle><description>Atrial fibrillation (AF) is an increasingly prevalent condition and the most common sustained arrhythmia encountered in ambulatory and hospital practice. 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Importantly, HTN is one of the few modifiable AF risk factors, and guideline-directed management of HTN may reduce the incidence of AF.</description><subject>Atrial Fibrillation - diagnosis</subject><subject>Atrial Fibrillation - epidemiology</subject><subject>Atrial Fibrillation - physiopathology</subject><subject>Atrial Fibrillation - prevention & control</subject><subject>Comorbidity</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension - diagnosis</subject><subject>Hypertension - epidemiology</subject><subject>Hypertension - physiopathology</subject><subject>Hypertension - therapy</subject><subject>Incidence</subject><subject>Prevalence</subject><subject>Prognosis</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><issn>1947-6094</issn><issn>1947-6108</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUT1PwzAQtRCIImBlRBkZSPE5bmwzIKEKKFIRDDAwWY5zaV3lo9gpEv8el5YKbrnz-fndOz9CzoAOgQslrprSLlKAlKeMyT1yBIqLNAcq939rqviAnIawoDEyASKnh2TABB0JptgReb_tvTN1cu8K7-ra9K5rE9OWyeRrib7HNsTGdfKEdm5aF3pnL5O7pSuxcV3dzdbHNfrVo-kbbPvkxXhT11iHE3JQmTrg6TYfk7f7u9fxJJ0-PzyOb6epzehIpjzn3EqJVoKCnEqRGVlJMFiBLAFKUVSMs5wxkFZQYxlHoCNT5AVgCXGnY3Kz4V2uigZLG0VEBXrpXWP8l-6M0_9vWjfXs-5TcwmcUhUJLrYEvvtYYeh144LF-BktdqugQQglZQZKRuhwA7W-C8FjtRsDVP9YoteWaADNdbQkPjj_K24H_zUg-wYtDoiT</recordid><startdate>20151001</startdate><enddate>20151001</enddate><creator>Ogunsua, Adedotun A</creator><creator>Shaikh, Amir Y</creator><creator>Ahmed, Mohamed</creator><creator>McManus, David D</creator><general>The Methodist Hospital Houston, Texas</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20151001</creationdate><title>Atrial Fibrillation and Hypertension: Mechanistic, Epidemiologic, and Treatment Parallels</title><author>Ogunsua, Adedotun A ; Shaikh, Amir Y ; Ahmed, Mohamed ; McManus, David D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3058-4644c88ec819160873a8f81aef18d11d7bf24262218c70ac24e105ab6b1ed1003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Atrial Fibrillation - diagnosis</topic><topic>Atrial Fibrillation - epidemiology</topic><topic>Atrial Fibrillation - physiopathology</topic><topic>Atrial Fibrillation - prevention & control</topic><topic>Comorbidity</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Hypertension - diagnosis</topic><topic>Hypertension - epidemiology</topic><topic>Hypertension - physiopathology</topic><topic>Hypertension - therapy</topic><topic>Incidence</topic><topic>Prevalence</topic><topic>Prognosis</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ogunsua, Adedotun A</creatorcontrib><creatorcontrib>Shaikh, Amir Y</creatorcontrib><creatorcontrib>Ahmed, Mohamed</creatorcontrib><creatorcontrib>McManus, David D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Methodist DeBakey cardiovascular journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ogunsua, Adedotun A</au><au>Shaikh, Amir Y</au><au>Ahmed, Mohamed</au><au>McManus, David D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Atrial Fibrillation and Hypertension: Mechanistic, Epidemiologic, and Treatment Parallels</atitle><jtitle>Methodist DeBakey cardiovascular journal</jtitle><addtitle>Methodist Debakey Cardiovasc J</addtitle><date>2015-10-01</date><risdate>2015</risdate><volume>11</volume><issue>4</issue><spage>228</spage><epage>234</epage><pages>228-234</pages><issn>1947-6094</issn><eissn>1947-6108</eissn><abstract>Atrial fibrillation (AF) is an increasingly prevalent condition and the most common sustained arrhythmia encountered in ambulatory and hospital practice. 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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Atrial Fibrillation - diagnosis Atrial Fibrillation - epidemiology Atrial Fibrillation - physiopathology Atrial Fibrillation - prevention & control Comorbidity Humans Hypertension Hypertension - diagnosis Hypertension - epidemiology Hypertension - physiopathology Hypertension - therapy Incidence Prevalence Prognosis Risk Assessment Risk Factors |
| title | Atrial Fibrillation and Hypertension: Mechanistic, Epidemiologic, and Treatment Parallels |
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